A5087439218- Neuroinflammation and Neurodegeneration Mechanisms
- Thermal Regulation in Medicine
- Acute Ischemic Stroke Management
- Cardiac Ischemia and Reperfusion
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Stroke Rehabilitation and Recovery
- Dental Trauma and Treatments
- Tryptophan and brain disorders
- Autophagy in Disease and Therapy
- Ultrasound and Hyperthermia Applications
- Neonatal and fetal brain pathology
- Thermoregulation and physiological responses
- Diabetic Foot Ulcer Assessment and Management
- Hemoglobin structure and function
- Cancer-related molecular mechanisms research
- Bariatric Surgery and Outcomes
- Regulation of Appetite and Obesity
- E-commerce and Technology Innovations
- Dental Implant Techniques and Outcomes
- Vagus Nerve Stimulation Research
- Muscle Physiology and Disorders
- Systemic Sclerosis and Related Diseases
- Cardiovascular Effects of Exercise
Wayne State University
2020-2025
The University of Texas MD Anderson Cancer Center
2025
Creative Commons
2023
Neurological Surgery
2023
Capital Medical University
2021-2023
Capital University
2021
Beijing Luhe Hospital Affiliated to Capital Medical University
2021
Wonju Severance Christian Hospital
2021
Yonsei University
2021
Stroke is one of the primary causes morbidity and death worldwide. While intravenous (IV) thrombolysis with alteplase has been widely proven to be beneficial for acute ischemic stroke patients, it still many limitations. Tenecteplase, a revised version alteplase, potential alternative IV thrombolytic agent that benefits over alteplase. The aim this mini-review summarize advancements in severe stroke, specifically development transition from tenecteplase.
Over decades, nearly all attempts to translate the benefits of therapeutic hypothermia in stroke models lower-order species patients have failed. Potentially overlooked reasons may be biological gaps between different and mismatched initiation translational studies. Here, we introduce a novel strategy selective non-human primate ischemia-reperfusion model, which autologous blood was cooled ex vivo cool transfusion administered at middle cerebral artery just after onset reperfusion. Cold...
Stroke is a leading threat to human life. Metabolic dysfunction of glucose may play key role in stroke pathophysiology. Pharmacological hypothermia (PH) potential neuroprotective strategy for stroke, which the temperature decreased safely. The present study determined whether PH with chlorpromazine and promethazine (C + P), plus dihydrocapsaicin (DHC) improved metabolism acute ischemic stroke. A total 208 adult male Sprague Dawley rats were randomly divided into following groups: sham,...
Abstract There remain debates on neuroprotection and rehabilitation techniques for acute ischemic stroke patients. Therapeutic physical exercise following has shown promise but is challenging to apply clinically. Ischemic conditioning, which several clinical advantages, a potential neuroprotective method that less understood. In the present study, rehabilitative properties mechanisms of remote postconditioning (RIPostC) after were compared determined. A total 248 adult male Sprague-Dawley...
Abstract Purpose: We examined baseline diet and its association with outcomes social determinants of health (SDoH) factors among patients (pts) enrolled in early-phase immune checkpoint blockade-included combination trials a comprehensive cancer center. Methods: Pts (ECOG 0-1) scheduled to begin an trial blockade were recruited into prospective, longitudinal study design, completed the validated Multifactor Dietary Screener (0-8, higher score = more frequent use food during past 30 days)...
While it is well-known that pre-stroke exercise conditioning reduces the incidence of stroke and development comorbidities, unclear whether post-stroke also neuroprotective. The present study investigated postconditioning (PostE) induced neuroprotection elucidated involvement SIRT1 regulation on ROS/ER stress pathway. Adult rats were subjected to middle cerebral artery occlusion (MCAO) followed by either: (1) resting; (2) mild (MPostE); or (3) intense (IPostE). PostE was initiated 24 h after...
Background and Purpose. Studies have shown that interischemia hypothermia is able to reduce the size of myocardial infarctions improve their clinical outcomes. The present study determined whether induced by pharmacological approach stronger neuroprotection in ischemic brains. Methods. Adult male Sprague Dawley rats were studied 4 groups: (1) sham; (2) stroke; (3) stroke treated with before reperfusion (interischemia hypothermia); (4) after initiated (inter-reperfusion hypothermia)....
Rehabilitation is essential in reducing stroke disability and should be performed as early possible. Exercise an established effective rehabilitation method; however, its implementation has been limited very use exacerbates cerebral injury restricted by patients' unstable conditions disabilities. Remote ischemic conditioning (RIC) a passive accessible therapy acute phases of appears to have similar neuroprotective effects exercise. This study assessed the safety feasibility novel...
Objective: Exercise rehabilitation is an effective therapy in reducing the disability rate after stroke and should be carried out as early possible. However, very exercise exacerbates brain injury difficult to conduct patients due their weakened potentially disabled state. It valuable explore additional strategies. Remote Ischemic Conditioning (RIC) a novel designed protect vital organs from severe lethal ischemic by transient sublethal blood flow non-vital organs, including distal limbs,...
Cardiovascular disease (CVD) is the leading cause of death around world, warranting an increasing number studies for its treatment. Among all therapeutical strategies, engineered exosomes are attracting growing attention due to their excellent biocompatibility, non-immunogenicity, and favorable plasticity. Despite popularity, there yet be a bibliometric analysis regarding application in CVD Therefore, present study assessed current trends treating by conducting analysis. All associated...
This study aimed to evaluate the effects of national dental screening for children in Korea aspects prevention caries, number treatments related and cost care.The used cohort data on health provided by National Health Insurance Service, analyzed 32,937 1st screening, 22,608 2nd 13,708 3rd 241,043 cases from care 27,944 born year 2008 2009. The decayed-filled teeth index person rate, calculated results decreased as preceding increased. Glass ionomer amalgam restoration, pulp treatment primary...
Objectives To explore the alterations in immune cell composition peripheral blood patients with acute ischemic stroke (AIS) based on their age group. Methods Patients imaging confirmed AIS were enrolled from April 2019 to January 2020 and divided into three groups according ages: <55 years (group-A), 55 – 65 (group-B), >65 (group-C). Blood samples collected immediately when admitted our ward prior any intervention. Flow cytometry was used analyze blood. Results A total of 41...
Background: Air pollution is one of the greatest public health concerns worldwide. In order to understand its mechanism harm, we investigated effects diesel exhaust particles (DEPs), major constituents ambient air pollutants, on reactive cell viability, oxygen stress, autophagy, and apoptosis.Materials Methods: in vitro human umbilical vein endothelial (HUVEC) model, cells were exposed freshly dispersed DEP preparations at 0, 12.5, 25, 50, 100, or 200 µg/mL for 24 h 50 1, 3, 6, 12, h. Cell...
The purpose of this study was to analyze the characteristics pediatric and adolescent patients who received sealant after health insurance coverage based on demographic factors such as gender, age, type, care institution region.<br/>Patient Sample Data from Health Insurance Review Assessment Service were used for study. A total 8,454,636 patients’ data obtained 2010 2017. Of these, 114,680 got treatment. Females more likely receive treatment than males. 5 - 9 year age group showed...
Abstract A depressive or hibernation-like effect of chlorpromazine and promethazine (C + P) on brain activity was reported to induce neuroprotection, with without induced-hypothermia. However, the underlying mechanisms remain unclear. The current study evaluated pharmacological function C P inhibition neuroinflammatory response inflammasome activation after ischemia/reperfusion. total 72 adult male Sprague-Dawley rats were subjected 2 h middle cerebral artery occlusion (MCAO) followed by 6...