A5037432090- Acute Lymphoblastic Leukemia research
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- RNA modifications and cancer
- Gene expression and cancer classification
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Phytochemistry and biological activities of Ficus species
- Oral and Maxillofacial Pathology
- Childhood Cancer Survivors' Quality of Life
- Lymphoma Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Genetic Associations and Epidemiology
- Physical Activity and Health
- Cancer Treatment and Pharmacology
- Global Cancer Incidence and Screening
- CRISPR and Genetic Engineering
- Birth, Development, and Health
- Cancer survivorship and care
- Pluripotent Stem Cells Research
North University of China
2025
New Mexico Cancer Center
2014-2024
University of New Mexico
2015-2024
UNM Comprehensive Cancer Center
2011-2024
Northwest University
2024
Daping Hospital
2023
Army Medical University
2023
Capital Medical University
2022
Harvard University
2022
Twin Cities Orthopedics
2022
Abstract Early detection and accurate monitoring of chronic kidney disease (CKD) could improve care retard progression to end-stage renal disease. Here, using untargeted metabolomics in 2155 participants including patients with stage 1–5 CKD healthy controls, we identify five metabolites, 5-methoxytryptophan (5-MTP), whose levels strongly correlate clinical markers 5-MTP decrease CKD, mouse kidneys after unilateral ureteral obstruction (UUO). Treatment ameliorates interstitial fibrosis,...
Abstract Adenoid cystic carcinoma (ACC), the second most common malignancy of salivary glands, is a rare tumor with bleak prognosis for which therapeutic targets are unavailable. We used RNA sequencing (RNA-seq) to analyze low-quality from archival, formaldehyde-fixed, paraffin-embedded samples. In addition detecting ACC translocation, t(6;9) fusing MYB proto-oncogene NFIB, we also detected previously unknown t(8;9) and t(8;14) translocations MYBL1 gene NFIB RAD51B genes, respectively....
Abstract The ubiquitous existence of microplastics and nanoplastics raises concerns about their potential impact on the human reproductive system. Limited data exists within system consequences sperm quality. Our objectives were to quantify characterize prevalence composition both canine testes investigate associations with count, weights testis epididymis. Using advanced sensitive pyrolysis-gas chromatography/mass spectrometry, we quantified 12 types 47 23 testes. Data organ weights, count...
To identify children with acute lymphoblastic leukemia (ALL) at initial diagnosis who are risk for inferior response to therapy by using molecular signatures.Gene expression profiles were generated from bone marrow blasts a cohort of 99 National Cancer Institute-defined high-risk ALL treated uniformly on the Children's Oncology Group (COG) 1961 study. For prediction early response, genes that correlated status day 7 identified training set and validated test set. An additional signature was...
Background Older cancer survivors are at risk of the development or worsening both age- and treatment-related morbidity. Sedentary behavior increases exacerbates these chronic conditions. Light-intensity physical activity (LPA) is more common in older adults associated with better health well-being. Thus, replacing sedentary time LPA may provide a successful strategy to reduce increase activity. Objective This study primarily aims evaluate feasibility, acceptability, preliminary efficacy...
To investigate the safety and efficacy of normobaric hyperoxia (NBO) combined with endovascular treatment (EVT) in patients acute ischemic stroke (AIS).In this single-center, proof-of-concept, assessor-blinded, randomized, controlled pilot study, AIS anterior circulation large vessel occlusion who had an indication for EVT were randomly assigned to group or NBO + group. The was given 100% oxygen through a face mask initiated before vascular recanalization (10L/min 4 hours), while room air....
One promising approach for early detection of lung cancer is by monitoring gene promoter hypermethylation events in sputum. Epidemiologic studies suggest that dietary fruits and vegetables the micronutrients they contain may reduce risk cancer. In this study, we evaluated whether diet multivitamin use influenced prevalence methylation cells exfoliated from aerodigestive tract current former smokers. Members (N = 1,101) Lovelace Smokers Cohort completed Harvard Food Frequency Questionnaire...
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared that of B ALL. Here, we show Runt-related transcription factor 2 (RUNX2) was upregulated in high-risk T-ALL KMT2A rearrangements (KMT2A-R) or immature immunophenotype. In KMT2A-R cells, identified RUNX2 as a direct target the chimeras, where it reciprocally bound promoter, establishing regulatory feed-forward mechanism. Notably, required for survival and cells vitro vivo. We...
The pH value of the hydrothermal solution was changed by changing washing ways R-KTNWs to adjust morphology and photocatalytic activity TiO 2 particles.
Ovarian cancer is the leading cause of death from gynecologic cancers in United States. Failure may be due to variable expression and/or complex interactions growth factor receptors individual tumors. As ErbB3-MET cooperativity implicated solid tumor resistance EGFR/ErbB2 inhibitors, we evaluated MET and all 4 ErbB family members ovarian cancers. Tissue arrays were prepared archival formalin-fixed paraffin-embedded samples, including 202 carcinomas (Stage I-IV) controls. Of patient only 25%...
Abstract Purpose: We previously identified the R-enantiomer of ketorolac as an inhibitor Rho-family GTPases Rac1 and Cdc42. Cdc42 regulate cancer-relevant functions, including cytoskeleton remodeling necessary for tumor cell adhesion migration. This study investigated whether administration racemic (R,S) after ovarian cancer surgery leads to peritoneal distribution R-ketorolac, target GTPase inhibition in cells retrieved from cavity, measureable impact on patient outcomes. Experimental...
// Candace A. Frerich 1 , Kathryn J. Brayer 1, 2 Brandon M. Painter Huining Kang Yoshitsugu Mitani 3 Adel K. El-Naggar and Scott Ness Department of Internal Medicine, University New Mexico Health Sciences Center, Albuquerque, NM, USA Comprehensive Cancer Head Neck Pathology, Texas MD Anderson Houston, TX, Correspondence to: Ness, email: sness@salud.unm.edu Keywords: personalized medicine; precision biomarker; emt; bioinformatics Abbreviations: ACC: Adenoid cystic carcinoma; FFPE:...
Adenoid cystic carcinoma (ACC) is an aggressive malignancy that most often arises in salivary or lacrimal glands but can also occur other tissues. We used optimized RNA-sequencing to analyze the transcriptomes of 113 ACC tumor samples from gland, breast skin. tumors different organs displayed remarkedly similar transcription profiles, and harbored translocations MYB MYBL1 genes, which encode oncogenic factors may induce dramatic genetic epigenetic changes leading a dominant ‘ACC phenotype’....