A5060742473- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Nail Diseases and Treatments
- Acne and Rosacea Treatments and Effects
- Analytical Methods in Pharmaceuticals
- Retinoids in leukemia and cellular processes
- Antibiotics Pharmacokinetics and Efficacy
- Natural Compounds in Disease Treatment
- Cancer survivorship and care
- Pharmacological Effects of Natural Compounds
- Quinazolinone synthesis and applications
- Epigenetics and DNA Methylation
- Biosimilars and Bioanalytical Methods
- Cytokine Signaling Pathways and Interactions
- Antifungal resistance and susceptibility
- Regulation of Appetite and Obesity
- Cancer Immunotherapy and Biomarkers
- Diabetes and associated disorders
- Sphingolipid Metabolism and Signaling
- Gastrointestinal Tumor Research and Treatment
- Biochemical Analysis and Sensing Techniques
- Flavonoids in Medical Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Ferroptosis and cancer prognosis
- Health Literacy and Information Accessibility
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
Guangxi Medical University
2021-2024
First Affiliated Hospital of GuangXi Medical University
2023
Peking Union Medical College Hospital
2022
University of California, San Francisco
2022
Chinese Academy of Medical Sciences Dermatology Hospital
2018-2021
Psoriasis is a common chronic inflammatory skin disease, which has seriously affected human health. Berberine plant alkaloid with significant anti-inflammatory effect. In this study, we aimed to determine whether topical application of berberine could ameliorate inflammation in psoriasis and explore the potential molecular mechanism. Imiquimod (IMQ)-induced psoriasis-like dermatitis mice was firstly used reveal pathogenic The transcriptome analysis showed that Janus kinase (JAK)-Signal...
Baicalin (BAI), the main active component of Scutellaria baicalensis, has significant anti-inflammatory and antibacterial effects. Echinacoside (ECH), an from Echinacea purpurea, antiangiogenesis antioxidant In previous studies, BAI or ECH been used for some skin inflammation problems by topical treatment. Psoriasis (PSO) is a common inflammatory disease with typical features such as excessive response vascular proliferation in lesions. Because effect antiangiogenic activity ECH, it proposed...
Preference for dietary fat vs. carbohydrate varies markedly across free-living individuals. It is recognized that food choice under genetic and physiological regulation, the central melanocortin system involved. However, how factors interact to regulate relative macronutrient intake not well understood.We investigated rich in influenced by cholesterol availability agouti-related protein (AGRP), orexigenic component of system. We assessed different metabolic parameters correlate with plasma...
Abstract: Pembrolizumab, a monoclonal antibody against programmed cell death-1 receptor, was licensed for advanced cancers. Although the use of pembrolizumab can enhance effect cancer treatment, it increase immune-related adverse events. We describe an elderly woman who developed ketoacidosis after receiving to treat metastatic melanoma. In presentation, laboratory analysis showed that hyperglycemia and anion gap metabolic acidosis consistent with diabetic ketoacidosis. Except pembrolizumab,...
A rapid, sensitive and selective HPLC–MS/MS method was developed validated for the quantification of cetirizine dihy-drochloride (CAS 83881-51-0) in human plasma using mosapride citrate as internal standard (IS, CAS 112885-42-4). Following liquid–liquid extraction, ana-lytes were separated a mobile phase consisting methanol aqueous ammonium acetate solution (10 mM) (60 : 40, v/v) on reverse C18 column analyzed by triple-quadrupole mass spectrometer selected reaction monitoring (SRM) mode...
Abstract A rapid, sensitive and specific high‐performance liquid chromatography–electrospray ionization mass spectrometry (LC‐ESI‐MS) method has been developed validated for the determination of oxatomide in human plasma. Flunarizine hydrochloride was employed as internal standard (IS). The analytes were chromatographically separated on a Shimadzu Shim‐pack VP‐ODS C 18 column (250 × 2.0 mm i.d.) with mobile phase consisting methanol aqueous ammonium acetate solution (10 m , pH 4.0; 85:15,...
<title>Abstract</title> Purpose To exploring the information needs and satisfaction levels of cancer patients in Guangxi, China. Methods A cross-sectional survey was conducted to investigate 335 two tertiary hospitals Data gathered using a general questionnaire EORTC QLQ-INFO25. Results The overall score QLQ-INFO25 is (50.47 ± 18.42). This included scores for disease (50.00, 33.33), medical test (66.67, 44.44), treatment-related 27.78), nursing related (44.44, 38.89), 48% (N = 162) had...
1.In this study, the pharmacokinetics of new triazole antifungal iodiconzole creams at target sites after single-dose topical application was investigated.2.30 healthy Chinese volunteers were randomly divided into three groups being stratified by sex, each group given a single dose 1%, 2%, 4% iodiconazole cream (0.4 g). Stratum corneum (SC) samples treated collected tape-stripping method chosen contact times, and extracted analysed validated LC-MS method.3.After creams, Cmax in SC 1.2 ± 0.7,...
Abstract Background Clear cell renal carcinoma (ccRCC) is a fatal urological malignancy, and surgery remains the primary treatment. Members of never in mitosis gene A (NIMA)-related kinase (NEK) family have been found to participate progression several cancers could be used as target genes treat corresponding diseases. Nonetheless, prognostic value immune infiltration levels NEK ccRCC remain unknown. Methods Gene Set Cancer Analysis (GSCA), Tumor Immune Estimation Resource (TIMER),...
Cutaneous microdialysis is a unique technique for in vivo examination of unbound drug concentrations dermis and subcutaneous tissues.Whenever the target tissue topical treatment,dermal (DMD) first choice acquisition real-time kinetic data.It has advantages research on penetration into skin with impaired barrier or lesions.In past decades,this developed quickly proved to be widely applicable,safe,and efficient tool dermatopharmacokinetic pharmacodynamic drugs.However,further warranted...
Objective To evaluate the association between isotretinoin pharmacokinetic parameters and CYP2B6 (cytochrome p-450) gene polymorphisms. Methods Blood samples were collected at different time points from 21 healthy male volunteers who received a single 40-rng oral dose of isotretinoin. High performance liquid chromatography-electrospray ionization mass spectrometry (LC-MS) was used for quantification in plasma which standardized by dosage body weight. PCR restriction fragment length...
Objective To assess the in vivo cutaneous bioavailability of iodiconazole a topical formulation. Methods Iodiconazole cream was topically administrated to ventral forearms 10 healthy volunteers for 1 hour, and excess formulation removed. The stratum corneum (SC) at application sites tape-stripped immediately or different time points, quantified gravimetrically, extracted analysis. Together with concomitant transepidermal water loss (TEWL) measurement, SC drug concentration-depth...