A5101804063- Cancer-related molecular mechanisms research
- COVID-19 and healthcare impacts
- RNA modifications and cancer
- Circular RNAs in diseases
- Metabolism, Diabetes, and Cancer
- COVID-19 Clinical Research Studies
- Phytochemical compounds biological activities
- Bone Metabolism and Diseases
- Marine Sponges and Natural Products
- Radiomics and Machine Learning in Medical Imaging
- BRCA gene mutations in cancer
- Reconstructive Surgery and Microvascular Techniques
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Prostate Cancer Diagnosis and Treatment
- Plant biochemistry and biosynthesis
- Health Systems, Economic Evaluations, Quality of Life
- PI3K/AKT/mTOR signaling in cancer
- Congenital heart defects research
- Economic and Financial Impacts of Cancer
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Nanoparticle-Based Drug Delivery
- Inflammatory Biomarkers in Disease Prognosis
Ningbo University
2022-2025
Zhuhai People's Hospital
2025
Ningbo Medical Center Lihuili Hospital
2022-2025
Jinan University
2025
Institut de Cancérologie de l'Ouest
2021-2024
China Pharmaceutical University
2024
Shandong University
2024
Chongqing Medical University
2024
Tianjin University of Traditional Chinese Medicine
2021-2024
Yunnan Agricultural University
2024
Abstract Bone scintigraphy (BS) is one of the most frequently utilized diagnostic techniques in detecting cancer bone metastasis, and it occupies an enormous workload for nuclear medicine physicians. So, we aimed to architecture automatic image interpreting system assist physicians diagnosis. We developed artificial intelligence (AI) model based on a deep neural network with 12,222 cases 99m Tc-MDP evaluated its performance metastasis. This AI demonstrated considerable performance, areas...
To investigate the expression and significance of long noncoding RNA NORAD (lncRNA-NORAD) in breast cancer.Q-PCR was adopted to detect mRNA lncRNA-NORAD cancer adjacent tissues, survival analysis compare low-expression groups with Kaplan-Meier method. Knockout observe effects on cell proliferation, migration invasion vitro vivo. The TGF-β/RUNX2 signaling pathway observed by Western blot after knockout lncRNA-NORAD.Increased tissues promotes cells correlated worse prognosis. LncRNA-NORAD...
Previous reports cite high costs of clinical cancer genetic testing as main barriers to patient's willingness test. We report findings a pilot study that evaluates how different subsidy schemes impact uptake and total cost management.We included all patients who attended the Cancer Genetics Service at National Centre Singapore (January 2014-May 2016). Two schemes, blanket scheme (100% eligible patients), varied (patients received 50%-100% dependent on financial status) were compared....
Abstract Here, an RNA‐sequencing assay revealed long noncoding RNAs (lncRNAs) with ectopic expression between colon cancer (CC) and normal epithelial cells, in which lncRNA B4GALT1‐AS1 exhibited the highest change. A 3‐(4,5‐dimethythiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide indicated that knockdown had no effect on CC cell viability, however, clone formation analysis showed attenuated capacity of formation. Additionally, gene set enrichment this data positive stem cell‐differentiated...
Glucocorticoid-induced osteoporosis (GIOP) is the common reason for secondary osteoporosis. Dendrobine (DEN) major biologically active component of
To perform a meta-analysis to compare the clinical outcomes and failure rate of anterior cruciate ligament (ACL) repair ACL reconstruction in acute rupture. Studies were searched on PubMed, Web Science, EMBASE for randomized controlled trials comparing versus The bias risk was based Cochrane Handbook Systematic Reviews Interventions. Clinical included IKDC score, Lysholm Tegner anteroposterior (AP) knee laxity, rate. funnel plots used detect publication bias. Six study (RCTs) this...
To explore the epidemiological characteristics of knee osteoarthritis (KOA) among elderly in community, and its correlation with bone mass loss. A cross-sectional study was conducted on community population over 50 year old from 12 health service centers Zhejiang province. Their gender, age, body index (BMI), T value KOA diagnosis were collected using face to questionnaire survey. Univariate regression used analyze influence BMI loss KOA. Logistic multivariate model independent effect Among...
Purpose: To meet increasing demand for cancer genetic testing and improve value-based care delivery, National Cancer Centre Singapore restructured the Genetics Service in 2014. Care delivery processes were redesigned. We sought to access by clinic capacity of 100% within 1 year without direct personnel costs. Methods: Process mapping plan-do-study-act (PDSA) cycles used a quality improvement project clinic. The impact interventions was evaluated tracking weekly number patient consultations...
Aims: Osteosarcoma (OS) is an aggressive bone malignancy with poor prognosis. Many OS cells are resistant to apoptotic induction by tumor necrosis factor-related apoptosis inducing ligand (TRAIL). In our previous study, we found that the serum level of cytochrome c1 (CYC1) significantly higher in patients than healthy subjects. Our aim was investigate effects CYC1 silencing on TRAIL-induced human vitro and vivo along underlying mechanisms. Methods: First, determined expression tumors cell...
Genistein can prevent tumorigenesis and reduce the incidence of diseases that are dependent upon estrogen. Previous research, however, has shown genistein also increase risk breast cancer. Thus, aim present study was to investigate mechanism underlying effect in cancer determine whether produces a therapeutic or promotes development Gene microarray data obtained from three samples treated with alcohol (control group), 3 µmol/l 10 for 48 h, were downloaded Expression Omnibus database....
Kupffer cells (KCs) play a crucial role in the pathogenesis of acute-on-chronic liver failure (ACLF) which is characterized by acute and severe disease patients with preexisting shows high mortality. Long noncoding RNAs (lncRNAs) are recently found to be involved gene regulation. However, mechanisms how KCs regulated inflammatory factors, tumor necrosis factor-α (TNF-α), whether lncRNAs process remain largely unknown. Hence, we investigated cytotoxicity TNF-α on KCs.lncRNA array (The...
To evaluate the cost-effectiveness of moderate Hypofractionated Radiotherapy (H-RT) compared to Conventional (C-RT) for intermediate-risk prostate caner (PCa).A prospective randomized clinical trial including 222 patients from six French cancer centers was conducted as an ancillary study international PROstate Fractionated Irradiation Trial (PROFIT). We carried-out a analysis (CEA) payer's perspective, with time horizon 48 months. Patients assigned H-RT arm received 6000 cGy in 20 fractions...
Compound Chinese medicine (F1) is a traditional prescription in that commonly used to treat spleen deficiency diarrhea (SDD). It has demonstrated remarkable effectiveness clinical practice. However, the precise mechanism by which it exerts its antidiarrheal effect still unclear. This study aimed at investigating efficacy and of F1 on senna-induced secretory Senna was utilized induce development mouse model (SDD) order observe rate diarrhea, index, blood biochemistry, histopathological...
Among the bioactive compounds, lipid-soluble tanshinone is present in Salvia miltiorrhiza , a medicinal plant species. While it known that ethephon has ability to inhibit tanshinones biosynthesis S. hairy root, however underlying regulatory mechanism remains obscure. In this study, using transcriptome dataset of root induced by ethephon, an ethylene-responsive transcriptional factor EIN3-like 1 ( SmEIL1 ) was identified. The protein found be localized nuclei, and confirmed transient...
Abstract Hepatocellular carcinoma (HCC) is one of the most aggressive tumours with marked fibrosis. Mycophenolate mofetil (MMF) was well‐established to have antitumour and anti‐fibrotic properties. To overcome poor bioavailability MMF, this study constructed two MMF nanosystems, MMF‐LA@DSPE‐PEG MMF‐LA@PEG‐PLA, by covalently conjugating linoleic acid (LA) then loading conjugate into polymer materials, PEG 5k ‐PLA 8k DSPE‐ 2k , respectively. cell lines C57BL/6 xenograft model were used examine...
Abstract Precise and specific spatiotemporal domains of gene expression regulation are critical for embryonic development. Recent studies have identified GLTSCR1 as a transcriptional elongation regulator in cancer research. However, the function GLTSCR1, especially development, remains poorly understood. Here, we found that was essential cardiac development because Gltscr1 knockout (Gltscr1 −/− ) led to lethality mice with severe congenital heart defects (CHDs). Ventricular septal defect...
Abstract Background Risk management programs targeting women with genetic predispositions to breast cancer (BC), eg, BRCA1 and BRCA2, are effective assuming full adherence the program protocol. However, high risk BC in equal access care may not result uniform program. Objective To elucidate factors influencing screening BC. Material Methods We retrieved data from a multicenter pathogenic-related surveillance across 4 French regions. used multilevel logistic modeling analyze of program,...