Purpose: Schizophrenia and epilepsy may share a mutual susceptibility. This study examined the bidirectional relation between two disorders. Methods: We used claims data obtained from Taiwan National Health Insurance database to conduct retrospective cohort analyses. Analysis 1 compared 5,195 patients with incident schizophrenia diagnosed in 1999–2008 20,776 controls without disease randomly selected during same period, frequency matched sex age. 2 comprised similar method compare 11,527...

Background This study presents an evaluation of the bidirectional correlation between attention deficit hyperactivity disorder (ADHD) and epilepsy using 2 cohorts from same population database. Methods We used data Taiwan National Health Insurance Research Database to establish separate cohort studies with participants <19 years old. subdivided Cohort 1 in groups: (1) 2468 patients initially diagnosed during period 1999–2008, (2) 9810 randomly selected sex- age-matched non-epileptic...

The temporal relationship between Tourette syndrome (TS) and depression is unclear. This cohort study evaluates the TS in Taiwan.Claims data from Taiwan National Health Insurance database were used to conduct retrospective analyses. contained 1337 patients who frequency matched by sex, age, urbanization of residence area, parental occupation, baseline year with 10 individuals without TS. Cox's proportional hazard regression analysis was conducted estimate effects on risk.In TS, risk...

Aim Attention‐deficit‐hyperactivity disorder ( ADHD ) is a that associated with accidental injuries. The aim of this study was to evaluate the relationship between and bone fracture in children. Method cohort comprised 3640 children (2874 males, 766 females; mean age 8y 5mo, SD 3y) (International Classification Diseases, Ninth Revision) who were matched without at ratio 1:4 n =14 560; 11 496 3064 3y). A Cox proportional hazard regression analysis conducted estimate how affected risk...

Linkage between allergy and increased immune response activation in Tourette syndrome (TS) has been reported. We performed a matched case-control study to evaluate correlation allergic diseases TS.Data this were from the Taiwan National Health Insurance Research Database. The sample comprised 845 2- 18-year-old patients with newly diagnosed TS 2003–2007 3378 controls frequency cases on age, sex, urbanization level. Unconditional logistic regression estimated odds ratios (ORs) 95% confidence...

Abstract Inflammation and genetics may play a role in the pathogenesis of febrile seizures (FSs). We aimed to test whether interleukin‐1β (IL‐1β), IL‐1 receptor antagonist (IL‐1 Ra), IL‐6 promoter, IL‐8, IL‐10, or tumor necrosis factor (TNF) gene polymorphisms could be used as markers susceptibility FSs. An association study was performed among cohort 104 patients with FSs 143 normal control subjects. There no significant difference between controls distribution allele frequencies IL‐1β exon...

Cardiac rhabdomyoma (CR) is the most common cardiac tumor in newborns. Approximately 75% of cases are associated with tuberous sclerosis complex. Although these tumors usually spontaneously regress after 2 years age, they can be life-threatening when obstruct major inflow or outflow pathways. Everolimus an inhibitor mammalian target rapamycin, reducing its production proteins harmartin and tuberin. has demonstrated a remarkable suppression effect children complex at doses 4.7–5.6 mg/M2/day...

Background and Purpose — In premature infants, many of whom experience ischemic brain insults, the environment rearing influences cognitive outcome. We developed a model to evaluate effect conditions on learning after unilateral cerebral hypoxia-ischemia (HI) in 7-day-old (P7) rats. hypothesized that neonatal handling would benefit rats recovering from an episode HI. Methods Seventeen litters P7 Long-Evans underwent either HI (right carotid ligation followed by 1.5 hours 8% O 2 ) or control...

Obesity is one of the main causes preventable death. Complications childhood obesity include cardiovascular risk, impaired glucose tolerance, type 2 diabetes mellitus, and acanthosis nigricans (AN; associated with as a manifestation cutaneous insulin resistance). An interaction between AN well detailed mechanism for pre- co-obesity appearance in children are still to be revealed. This research tries assess involvement insulin/insulin-like growth factor (IGF) receptor pathway via study...

Enterovirus (EV) infection is a major public health issue throughout the world with potential neurological complications. This study evaluated relationship between attention deficit hyperactivity disorder (ADHD) and EV encephalitis in children. Data of reimbursement claims from National Health Insurance Research Database Taiwan were used population-based case–control design. The comprised 2646 children ADHD who matched according to sex, age, urbanization level residence, parental occupation,...

We report the case of a 2-year-old male with congenital symmetric facial diplegia, and bilateral paralysis abduction eyes. Findings were compatible diagnosis Möbius syndrome. Routine G-banded chromosome analysis revealed mosaic karyotype 40 cells showing normal 46,XX 10 46,XY. An XX attributed to XX/XY mosaicism was diagnosed. The phenotype our patient did not coincide any described form reversal syndrome, but unique combination both syndromes. disorder this is likely represent genetic...

Recent research suggests that Tourette's syndrome (TS) may result from a defect in the dopamine system. Several candidate gene polymorphisms have been implicated attention deficit hyperactivity disorder, including transporter (DAT1) and β-hydroxylase (DBH) genes. A high rate of comorbidity between disorder TS indicates they share same pathophysiology. We aimed to test hypothesis might play role TS. An association study, using an independent sample patients midland region Taiwan, was...

Background: Central nervous system (CNS) infection in childhood can lead to neurological sequelae, including epilepsy, and neurodevelopmental disorders, such as attention-deficit/hyperactivity disorder (ADHD) autism spectrum (ASD). This study investigated the association of etiologically diagnosed brain infections with subsequent risks epilepsy disorders. Objectives: We retrospectively analyzed data children aged <18 years who had definite positive cerebrospinal fluid cultures from January...

Abstract Background Kawasaki disease (KD) is a common vasculitis of childhood in East Asia. The complications KD ascribed to long-term cardiovascular sequelae are considerably diverse. Although studies have investigated neurodevelopmental problems following the past few decades, they reported inconsistent conclusions. This study potential epilepsy and associated disorders (NDDs) Taiwanese children. Methods We retrospectively analyzed data children aged &lt; 18 years with clinically diagnosed...

Cytomegalovirus (CMV) is a ubiquitous virus, and CMV-associated diseases range from mild illness in immunologically normal hosts to life-threatening newborns immunocompromised children. This study investigated the association between childhood CMV infection subsequent epilepsy or neurodevelopmental disorders, attention deficit hyperactivity disorder (ADHD), autism spectrum (ASD). A retrospective analysis was performed on data for 69 children with confirmed infections (CMV group) 292 patients...