Jeng-Sheng Chang

ORCID: 0009-0003-3603-5627
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About
Contact & Profiles
Research Areas
  • Coronary Artery Anomalies
  • Kawasaki Disease and Coronary Complications
  • Congenital Heart Disease Studies
  • Cardiovascular Issues in Pregnancy
  • Congenital Diaphragmatic Hernia Studies
  • Cardiac Arrhythmias and Treatments
  • Lymphatic Disorders and Treatments
  • Mechanical Circulatory Support Devices
  • Cardiac pacing and defibrillation studies
  • Blood Coagulation and Thrombosis Mechanisms
  • Cardiac Valve Diseases and Treatments
  • Tumors and Oncological Cases
  • Tuberous Sclerosis Complex Research
  • Myasthenia Gravis and Thymoma
  • Infective Endocarditis Diagnosis and Management
  • Hip disorders and treatments
  • Vasculitis and related conditions
  • Bone fractures and treatments
  • Viral Infections and Immunology Research
  • Infant Development and Preterm Care
  • Vascular Anomalies and Treatments
  • Vascular anomalies and interventions
  • Pneumothorax, Barotrauma, Emphysema
  • Adolescent and Pediatric Healthcare
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Mayo Clinic in Arizona
2025

China Medical University Hospital
1999-2025

China Medical University
2010-2025

Weatherford College
2021

National Taiwan University Hospital
1992-2019

Royal Brompton Hospital
2019

Kyungpook National University Hospital
2019

Ramathibodi Hospital
2019

Queen Mary Hospital
2019

China Medical University
2008

The orb gene of Drosophila encodes sex-specific germ-line proteins that contain two RRM-type RNA-binding domains. Here we report the distribution Orb protein in wild-type, tumorous, and mutant ovaries. wild-type during oogenesis resembles its RNA, preferentially accumulating cytoplasm developing oocyte shortly after formation 16-cell cyst. As anticipated from expression, mutations lead to female sterility. Analysis effect mutants on RNAs known be required for differentiation polarity...

10.1101/gad.8.5.598 article EN Genes & Development 1994-03-01

Background Ongoing low-grade inflammation and endothelial dysfunction persist in patients late after Kawasaki disease (KD). Statins not only reduce cholesterol, but also improve surrogate markers of atherosclerosis dysfunction, their effects for children KD complicated with coronary arterial abnormality (CAA) has been evaluated. Methods Results The 11 CAA (mean age 12.9±2.5 years, mean interval from episode 10.77±3.01 years) age- gender-matched healthy controls were studied. group received...

10.1253/circj.cj-08-0121 article EN Circulation Journal 2008-01-01

Cardiac rhabdomyoma (CR) is the most common cardiac tumor in newborns. Approximately 75% of cases are associated with tuberous sclerosis complex. Although these tumors usually spontaneously regress after 2 years age, they can be life-threatening when obstruct major inflow or outflow pathways. Everolimus an inhibitor mammalian target rapamycin, reducing its production proteins harmartin and tuberin. has demonstrated a remarkable suppression effect children complex at doses 4.7–5.6 mg/M2/day...

10.1007/s00246-017-1688-4 article EN cc-by Pediatric Cardiology 2017-08-05

Abstract Medical decisions should be well-planned to improve prognosis and reduce complications of mediastinal tumors. In this study, we analyzed the clinical presentations pediatric tumors their correlation with long-term outcome. Forty patients under 18 years age diagnosed at China University Children's Hospital between 2001 2016 were enrolled. The patients’ sex, onset, initial symptoms, treatment outcomes analyzed. 75% in study men, median onset was 13 old (age range: 0–17 years). overall...

10.1097/md.0000000000016732 article EN cc-by-nc Medicine 2019-08-01

Chest pain is a common complaint in children visiting the emergency department (ED). True organic problems like cardiac disease are rare. We assess and analyze etiology of chest among pediatric ED one medical center.We retrospectively reviewed records with who visited our between September 2002 June 2005. Any case trauma-associated was excluded from this study.A total 103 patients (64 boys, 39 girls; mean age, 13 years; age range, 4-17 years) were enrolled into study; 101 had radiograms...

10.1016/s1875-9572(08)60007-8 article EN publisher-specific-oa Pediatrics & Neonatology 2008-04-01

The use of thoracostomy tube for drainage parapneumonic effusion is an important therapeutic measure. In this study, we compared the effectiveness and complications between chest pigtail catheter pleural in children.We retrospectively reviewed medical records children with during period July 2001 through December 2003. Patients who received either or were enrolled into study. Medical records, such as age, sex, clinical presentation, subsequent therapies, hospital stay, laboratory data,...

10.1016/j.pedneo.2011.08.007 article EN publisher-specific-oa Pediatrics & Neonatology 2011-11-11

Background: Chylothorax in children is a relatively rare cause of pleural effusion.However, it usually common complication cardiothoracic operations like open-heart surgery.Other etiologies for chylothorax, such as trauma or malignancy, occur more adults and children.To explore the chylothorax children, this study analyzed pediatric patients that were admitted to onea medical center.Methods: We retrospectively reviewed records tertiary transfer center with diagnosis during period 1995...

10.1051/bmdcn/2017070105 article EN cc-by Biomedicine 2017-03-01

Summary Kawasaki disease (KD) is a pediatric systemic vasculitis of unknown etiology wherein genetic influence suspected. Gene clusters within the HLA region at chromosome 6p21.3 have been linked to KD and other autoimmune disorders. As collagen strong autoantigen inducing chronic inflammation in patients with vasculitis, this study tests hypothesis that single‐nucleotide polymorphism (SNP) gene, COL11A2 , located may affect susceptibility its arterial sequels. SNP sites rs2294478 (at...

10.1111/j.1744-313x.2010.00952.x article EN International Journal of Immunogenetics 2010-07-02

Abstract Although influenza is generally an acute, self-limited, and uncomplicated disease in healthy children, it can result severe morbidity mortality. The objectives of this study were to analyze compare the clinical features outcome pediatric with without central nervous system (CNS) involvement. We conducted a retrospective observational children admitted intensive care unit (PICU) China Medical University Children's Hospital Taiwan confirmed diagnosis influenza. demographic data,...

10.1097/md.0000000000025716 article EN cc-by-nc Medicine 2021-04-28

Thyroid stimulating hormone receptor antibodies (TSHRAbs) are specific autoantibodies of Graves' disease (GD). They activate adenylate cyclase, induce thyroid growth, and cause an increased rate production secretion. TSHRAbs levels decreased by treatment may predict recurrence when they persist. Theoretically, should be related to intrathyroid vascularity (ITV) due the autoimmunity inflammation. We aimed analyze relationship between represented thyrotropin-binding inhibitory immunoglobulin...

10.1055/s-0031-1297992 article EN Experimental and Clinical Endocrinology & Diabetes 2012-12-20

Kawasaki disease (mucocutaneous lymph node syndrome) is a of unknown aetiology that affects infants and children, with most patients having myocardial involvement. To evaluate the incidence nature involvement, 30 underwent both dipyridamole 201Tl-chloride single photon emission tomography (SPET) two-dimensional echocardiography (2D-Echo), which were performed within 7 days each other. The SPET images 15 (50%) showed 27 segments perfusion abnormalities: 6 had one or more showing...

10.1097/00006231-199705000-00005 article EN Nuclear Medicine Communications 1997-05-01

Introduction:In Thailand, the radiofrequency catheter ablation among arrhythmia with congenital heart disease was limited. Methods:The retrospective study symptomatic arrhythmic for procedure during 1 January 1996 until 31 December, 2017.Clinical data, were classified. Result: The inRamathibodi hospital 29 patients There male 11 (37.9%)patients, mean age 36.3 years old, ASD 10 (34.5%) and Ebstein's anormaly 9 (31.0%)patients, respectively.The efficacy of treatment 95.1%.The most common...

10.1002/joa3.12280 article EN cc-by-nc-nd Journal of Arrhythmia 2019-12-01
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