A5038907597- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Child and Adolescent Psychosocial and Emotional Development
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Maternal Mental Health During Pregnancy and Postpartum
- Birth, Development, and Health
- Early Childhood Education and Development
- Tryptophan and brain disorders
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Adipose Tissue and Metabolism
- Infant Development and Preterm Care
- Estrogen and related hormone effects
- Diabetes and associated disorders
- Child Nutrition and Feeding Issues
- Neurotransmitter Receptor Influence on Behavior
- Pituitary Gland Disorders and Treatments
- Fatty Acid Research and Health
- Maternal and Perinatal Health Interventions
- Obesity, Physical Activity, Diet
- Prenatal Substance Exposure Effects
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Effects and risks of endocrine disrupting chemicals
University of Michigan
2011-2021
Michigan Department of Health and Human Services
2021
Michigan United
2010-2017
Pediatrics and Genetics
1996-2009
C. S. Mott Children's Hospital
2008
Michigan Medicine
2008
Mental Health Research Institute
1992-2002
Regional West Medical Center
2002
China Medical University
2001
China Medical University Hospital
2001
Hippocampal glucocorticoid receptors (GR and MR) play an important role in negative feedback. Abnormalities feedback are found depression post-traumatic stress disorder (PTSD), suggesting that GR MR might be involved the pathophysiology of these disorders. Enhanced feedback, PTSD-specific neuroendocrine abnormality, can induced animals using a single prolonged (SPS) paradigm (a number different stressors one session, 'no stress' interval testing session week later). In current study, we...
This study evaluated whether sleep over the first 6 months of life was more disturbed in infants born to mothers who were depressed compared with from nondepressed mothers. Actigraphy recorded for 7 consecutive days starting at 2 weeks postpartum and monthly thereafter until age. Mothers completed daily sleep/wake diaries. Sleep data are presented here. The home environment. Eighteen healthy, full-term infants, 9 males females. Seven women no personal or family history depression; 11...
Dexamethasone is commonly used to lessen the morbidity of chronic lung disease in premature infants, but little known regarding neurological consequences its prolonged use. To study effects dexamethasone, we have developed a rat model which newborn pups are exposed tapering doses dexamethasone at time corresponding neurodevelopmentally human exposure neonatal intensive care unit. On postnatal day (PD) 2, litters were divided into three groups: 1) handled controls, 2) saline-injected animals,...
Neural development involves the expression of ensembles regulatory genes that control coordinate and region-specific a host other genes, resulting in unique structure, connectivity, function each brain region. Although role some specific neural has been studied detail, we have no global view orchestration spatial temporal aspects gene across multiple regions developing brain. To this end, used transcriptional profiling to examine levels 9955 hypothalamus, hippocampus, frontal cortex seven...
Permanent neonatal diabetes mellitus is a rare disorder known to be caused by activating mutations in KCNJ11 or ABCC8, inactivating INS, very rarely GCK insulin promotor factor-1 (IPF-1) genes. We report patient with permanent and severe exocrine pancreatic insufficiency. Ultrasound examination revealed agenesis suggestion of small amount tissue the head pancreas. Genetic testing that neonate had homozygous Pro63fsX60 IPF-1 mutation. This second reported case secondary mutation gene supports...
Vitamin D insufficiency may be associated with depressive symptoms in non-pregnant adults. We performed this study to evaluate whether low maternal vitamin levels are pregnancy. This was a secondary analysis of randomized trial designed assess prenatal omega-3 fatty acid supplementation would prevent symptoms. Pregnant women from Michigan who were at risk for depression based on Edinburgh Postnatal Depression Scale Score or history enrolled. Participants completed the Beck Inventory (BDI)...
Abstract Childhood poverty is hypothesized to increase risk for mental and physical health problems at least in part through dysregulation of the hypothalamic‐pituitary‐adrenal axis. However, less known about specific psychosocial stressors associated with cortisol reactivity regulation children living poverty. The current study investigates negative life events, household chaos, family conflict preschool middle childhood as potential predictors low‐income 7–10 year olds ( N = 242; M age 7.9...
Until recently, the synthetic glucocorticoid dexamethasone was commonly used to lessen morbidity of chronic lung disease in premature infants. This practice diminished as use linked an increased incidence cerebral palsy and short-term neurodevelopmental delay. Of more concern is fact that we know little regarding effects on long-term neurodevelopment. To study neonatal exposure neurodevelopment, have developed a rat model where newborn pups are exposed tapering doses at time points...