A5078217268- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Mental Health Research Topics
- Neuroscience and Neuropharmacology Research
- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Adipose Tissue and Metabolism
- Neural and Behavioral Psychology Studies
- Animal Behavior and Welfare Studies
- Neuroscience of respiration and sleep
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- Epigenetics and DNA Methylation
- Biochemical Analysis and Sensing Techniques
- Fibroblast Growth Factor Research
- Child and Adolescent Psychosocial and Emotional Development
- Anesthesia and Neurotoxicity Research
- Treatment of Major Depression
- Olfactory and Sensory Function Studies
- Pancreatic function and diabetes
- Neuropeptides and Animal Physiology
University of Michigan
2016-2025
Michigan United
2013-2025
Michigan CardioVascular Institute
2020-2021
Division of Chemistry
2014
Neuroscience Institute
2007
Mental Health Research Institute
2004
Pediatrics and Genetics
2002
If reward-associated cues acquire the properties of incentive stimuli they can come to powerfully control behavior, and potentially promote maladaptive behavior. Pavlovian are defined as that have three fundamental properties: attractive, themselves desired, spur instrumental actions. We found, however, there is considerable individual variation in extent which animals attribute motivational ("incentive salience") reward cues. The purpose this paper was develop criteria for identifying...
Even when trained under exactly the same conditions outbred male Sprague-Dawley (SD) rats vary in form of Pavlovian conditioned approach response (CR) they acquire. The CR (i.e. sign-tracking vs. goal-tracking) predicts to what degree individuals attribute incentive salience cues associated with food or drugs. However, we have noticed variation incidence these two phenotypes obtained from different vendors. In this study, quantified sign- and goal-tracking behavior a reasonably large sample...
Cues in the environment can elicit complex emotional states, and thereby maladaptive behavior, as a function of their ascribed value. Here we capture individual variation propensity to attribute motivational value reward-cues using sign-tracker/goal-tracker animal model. Goal-trackers predictive reward-cues, sign-trackers both incentive Using chemogenetics microdialysis, show that, sign-trackers, stimulation neuronal pathway from prelimbic cortex (PrL) paraventricular nucleus thalamus (PVT)...
Obesity is influenced by genetic and environmental factors. Despite the success of human genome-wide association studies, specific genes that confer obesity remain largely unknown. The objective this study was to use outbred rats identify loci underlying related morphometric metabolic traits.
Externalizing behaviors in childhood often predict impulse control disorders adulthood; however, the underlying bio-behavioral risk factors are incompletely understood. In animals, propensity to sign-track, or degree which incentive motivational value is attributed reward cues, associated with externalizing-type and deficits executive control. Using a Pavlovian conditioned approach paradigm, we quantified sign-tracking 40 healthy 9-12-year-olds. We also measured parent-reported externalizing...
Addiction vulnerability is associated with the tendency to attribute incentive salience reward predictive cues. Both addiction and attribution of are influenced by environmental genetic factors. To characterize contributions attribution, we performed a genome-wide association study (GWAS) in cohort 1596 heterogeneous stock (HS) rats. Rats underwent Pavlovian conditioned approach task that characterized responses food-associated stimuli ("cues"). Responses ranged from cue-directed...
Reinforcement Learning has greatly influenced models of conditioning, providing powerful explanations acquired behaviour and underlying physiological observations. However, in recent autoshaping experiments rats, variation the form Pavlovian conditioned responses (CRs) associated dopamine activity, have questioned classical hypothesis that phasic activity corresponds to a reward prediction error-like signal arising from Model-Free system, necessary for conditioning. Over course conditioning...
Significance Determining the factors that render an individual more susceptible or resilient to cocaine addiction has great implications for treatment. We exploit a unique model demonstrate genetic differences in vulnerability exist rat. examined gene expression and epigenetic regulation of two genes—fibroblast growth factor (FGF2) dopamine D2 receptor (D2)—in nucleus accumbens core. Low levels mRNA, via modifications, may play role susceptibility addiction. Specifically, binding repressive...