Wei‐Chou Chang

ORCID: 0000-0001-6756-8651
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About
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Research Areas
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Gastrointestinal disorders and treatments
  • Radiomics and Machine Learning in Medical Imaging
  • Lung Cancer Diagnosis and Treatment
  • MRI in cancer diagnosis
  • Gallbladder and Bile Duct Disorders
  • Hernia repair and management
  • Breast Lesions and Carcinomas
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Liver Disease Diagnosis and Treatment
  • Esophageal and GI Pathology
  • Amoebic Infections and Treatments
  • Liver Disease and Transplantation
  • Intestinal and Peritoneal Adhesions
  • Gastrointestinal Bleeding Diagnosis and Treatment
  • Biliary and Gastrointestinal Fistulas
  • Lung Cancer Treatments and Mutations
  • Diverticular Disease and Complications
  • Gastrointestinal Tumor Research and Treatment
  • Abdominal vascular conditions and treatments
  • Sarcoma Diagnosis and Treatment
  • Pancreatitis Pathology and Treatment
  • Infectious Diseases and Tuberculosis
  • Pancreatic and Hepatic Oncology Research
  • Venous Thromboembolism Diagnosis and Management

Tri-Service General Hospital
2016-2025

National Defense Medical Center
2015-2025

University of California San Francisco Medical Center
2021

Tri-Service General Hospital Songshan Branch
2020

National Yang Ming Chiao Tung University
2012-2016

National Yang Ming University Hospital
2014-2016

Young Women's Christian Association
2015

Smart High Tech (Sweden)
2015

SUNY Westchester Community College
2015

Taichung Armed Forces General Hospital
2009

Objectives In mouse models of pancreatic cancer, IPI-926, an oral Hedgehog inhibitor, increases chemotherapy delivery by depleting tumor-associated stroma. This multicenter phase Ib study evaluated IPI-926 in combination with FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, oxaliplatin) patients advanced cancer. Methods Patients were treated once-daily plus FOLFIRINOX. A 3 + dose escalation design was used, cohort expansion at the maximum tolerated dose. subset underwent perfusion...

10.1097/mpa.0000000000000458 article EN Pancreas 2015-09-19

Transient Respiratory Motion Artifact During Arterial Phase MRI With Gadoxetate Disodium: Risk Factor AnalysesSo Yeon Kim1, Seong Ho Park1, En-Haw Wu2, Z. Jane Wang3, Thomas A. Hope3, Wei-Chou Chang4 and Benjamin M. Yeh3Audio Available | Share

10.2214/ajr.14.13677 article EN American Journal of Roentgenology 2015-05-22

Abdominal aortic aneurysm (AAA) is a life-threatening disease affecting almost 10% of the population over age 65. Nitrogen-containing bisphosphonates (N-BPs) have been shown to exert anti-atherogenic and anti-angiogenic effects, but potential effects N-BPs on AAA remain unclear. Here, we tested whether potent N-BP, zoledronate, can attenuate formation Angiotensin II (Ang II)-induced in hyperlipidaemic mice.Low-density lipoprotein receptor(-/-) (LDLR(-/-)) mice infused for 28 days with Ang...

10.1093/cvr/cvt230 article EN Cardiovascular Research 2013-11-13

Background: Transcranial direct current stimulation (tDCS) is a non-invasive brain for treatment-resistant obsessive compulsive disorder (OCD). We aim to compare the treatment outcomes of newly developed dual-site cathodal tDCS method over orbitofrontal cortex (OFC) and pre-supplementary motor area (pre-SMA) two previously reported montages (cerebellum-OFC pre-SMA) in patients with OCD. Methods: Eighteen OCD were randomly assigned receive twice-daily 2 mA/20 min sessions 10 consecutive...

10.3390/medicina61020169 article EN cc-by Medicina 2025-01-21

In recent years, bipolar disorder (BD), a multifaceted mood marked by severe episodic fluctuations, has been shown to have an impact on disability-adjusted life-years (DALYs). The increasing prevalence of BD highlights the need for better di-agnostic tools , particularly those involving genetic insights. Genetic association studies can play crucial role in identifying variations linked BD, shedding light its ge-netic underpinnings and potential therapeutic targets. Our research utilized data...

10.20944/preprints202502.1288.v1 preprint EN 2025-02-18

ABSTRACT Background: Differentiate benign and malignant hepatic lesions with a limited phase of CT scan is practical clinical challenge. Aim: To evaluate the feasibility differentiation portal venous computed tomography (CT) images deep learning. Methods: This was retrospective single-center study; patients focal were detected in contrast-enhanced from January 2016 to December 2018 enrolled. Benign enrolled this study include cysts hemangioma; hepatocellular carcinoma (HCC) metastases....

10.4103/jmedsci.jmedsci_93_24 article EN cc-by-nc-sa Journal of Medical Sciences 2025-03-10

Background and Objectives: In recent years, bipolar disorder (BD), a multifaceted mood marked by severe episodic fluctuations, has been shown to have an impact on disability-adjusted life years (DALYs). The increasing prevalence of BD highlights the need for better diagnostic tools, particularly those involving genetic insights. Genetic association studies can play crucial role in identifying variations linked BD, shedding light its underpinnings potential therapeutic targets. This study...

10.3390/medicina61030486 article EN cc-by Medicina 2025-03-11

Several studies argue against the association between admission hyperglycemia and adverse outcomes in infected diabetic patients. When investigating association, it is necessary to consider preexisting hyperglycemia. The objective of this study was assess whether stress-induced hyperglycemia, determined by glycemic gap glucose levels A1c-derived average adversely affects patients admitted hospital with community-acquired pneumonia (CAP). We retrospectively analyzed hospitalized because CAP...

10.1097/md.0000000000001456 article EN cc-by-nc Medicine 2015-08-01

CT Findings for Detecting the Presence of Gangrenous Ischemia in CholecystitisWei-Chou Chang1, Yuxin Sun2, En-Haw Wu3, So Yeon Kim4, Z. Jane Wang2, Guo-Shu Huang1 and Benjamin M. Yeh2Audio Available | Share Claim CREDIT

10.2214/ajr.15.15658 article EN American Journal of Roentgenology 2016-06-02

The purpose of this study was to determine the contribution multidetector-row computed tomography (MDCT) in management adhesion-related small bowel obstruction (SBO) and identify its predictive value for surgery.We conducted a retrospective review 151 patients over 5-year period with diagnosis SBO caused by adhesion. These were divided into two groups: surgery (n = 63) observation group 88). Two radiologists blinded outcome evaluated MDCT images retrospectively, recording diameter, wall...

10.1371/journal.pone.0089804 article EN cc-by PLoS ONE 2014-02-24

To retrospectively determine the association between breast lesion morphology and malignancy to optimal value of enhancement (HU, Hounsfield units) improve diagnostic accuracy cancer in patients with incidental lesions (IBLs). A total 97 102 IBLs detected from July 2009 December 2012 were enrolled this study. Two radiologists analyzed CT images for presence based on alone combination an (HU) analysis. There 36 malignant 66 benign IBLs. When values combined, sensitivity, specificity, 92%,...

10.1371/journal.pone.0154569 article EN cc-by PLoS ONE 2016-04-29

Abstract Background Subjective cognitive decline (SCD) is an early stage of dementia linked to Alzheimer's disease pathology. White matter changes were found in SCD using diffusion tensor imaging, but there are known limitations voxel-wise tensor-based methods. Fixel-based analysis (FBA) can help understand white fibers and how they relate neurodegenerative proteins multidomain behavior data individuals with SCD. Methods Healthy adults normal cognition recruited the Northeastern Taiwan...

10.1186/s12993-024-00238-x article EN cc-by Behavioral and Brain Functions 2024-05-22

The purpose of this study was to verify the utility second-look ultrasonography (US) in evaluating nonmass enhancement (NME) lesions detected on breast magnetic resonance imaging (MRI) by analysing its correlation and features. From July 2008 June 2012, 102 consecutive MRI-detected NME were subsequently evaluated with US. Lesions according established Breast Imaging Reporting Data System (BI-RADS) lexicon. between lesion characteristics, size, histopathological findings features at US...

10.1111/tbj.12491 article EN The Breast Journal 2015-09-22
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