A5061645251- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- Neural and Behavioral Psychology Studies
- Radiomics and Machine Learning in Medical Imaging
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Medical Imaging and Pathology Studies
- Botulinum Toxin and Related Neurological Disorders
- Ultrasound and Hyperthermia Applications
- Neurological Disease Mechanisms and Treatments
- Sarcoma Diagnosis and Treatment
- Mind wandering and attention
- Ultrasound Imaging and Elastography
- Bone Tumor Diagnosis and Treatments
- Alzheimer's disease research and treatments
- Impact of Technology on Adolescents
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Management and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
Catholic University of Korea
2016-2025
Incheon St. Mary's Hospital
2015-2024
Swami Rama Himalayan University
2010
Institute of Medical Sciences
2010
Agricultural Biotechnology Research Center, Academia Sinica
2010
Jeju National University
2003-2007
Abstract Background Epilepsy is a common neurological disorder, which attributed to uncontrollable abnormal hyper-excitability of neurons. We investigated the feasibility using low-intensity, pulsed radiation focused ultrasound (FUS) non-invasively suppress epileptic activity in an animal model (rat), was induced by intraperitonial injection pentylenetetrazol (PTZ). Results After onset seizures, FUS transcranially administered brain twice for three minutes each while undergoing...
Parkinson’s disease (PD) and Alzheimer’s (AD) can coexist in severely affected; elderly patients. Since they have different pathological causes lesions consequently require treatments; it is critical to distinguish PD-related dementia (PD-D) from AD. Conventional electroencephalograph (EEG) analysis has produced poor results. This study investigated the possibility of using relative wavelet energy (RWE) coherence (WC) between PD-D patients; AD patients healthy subjects. In EEG signals; we...
Preclinical studies have suggested that low-intensity transcranial focused ultrasound (tFUS) may therapeutic potential for Alzheimer's disease (AD) by opening the blood-brain barrier (BBB), reducing amyloid pathology, and improving cognition. This study investigated effects of tFUS on BBB opening, regional cerebral metabolic rate glucose (rCMRglu), cognitive function in AD patients. Eight patients with received image-guided to right hippocampus immediately after intravenous injection...
Background: Transcranial direct current stimulation (tDCS) is a non-invasive brain for treatment-resistant obsessive compulsive disorder (OCD). We aim to compare the treatment outcomes of newly developed dual-site cathodal tDCS method over orbitofrontal cortex (OFC) and pre-supplementary motor area (pre-SMA) two previously reported montages (cerebellum-OFC pre-SMA) in patients with OCD. Methods: Eighteen OCD were randomly assigned receive twice-daily 2 mA/20 min sessions 10 consecutive...
Cerebral amyloid angiopathy (CAA) is known to be an important cause of spontaneous cortical-subcortical intracranial hemorrhage in normotensive older persons. CAA can also manifest as leukoencephalopathy, brain atrophy, and ischemia secondary hypoperfusion. Our goal was verify cerebral hypoperfusion patients with using (99m)Tc-ethylcysteinate dimer ((99m)Tc-ECD) perfusion SPECT.A total 11 (5 men 6 women; age range, 58-78 y; mean +/- SD, 70.0 7.0 y) clinically radiologically established...
Onju Ham, Chang Youn Lee, Byeong-Wook Song, Se-Yeon Ran Kim, Jun-Hee Park, Jiyun Hyang-Hee Seo, Chae Yoon Yong-An Chung, Lee-So Maeng, Min Young Jongmin Jihwan Hwang, Dong Kyun Woo, and Woochul Chang*. Mol. Cells 2014;37:449-56. https://doi.org/10.14348/molcells.2014.0023
The degree and salience of pain have been known to be constantly monitored modulated by the brain. In case maladaptive neural responses as reported in centralized conditions such complex regional syndrome (CRPS), perception is amplified remains elevated even without sustained peripheral inputs. Given that attentional state brain greatly influences interpretation pain, we investigated role attention network its dynamic interactions with other pain-related networks CRPS. We examined...
Abstract Brain network is organized to maximize the efficiency of both segregated and integrated information processing that may be related human intelligence. However, there have been surprisingly few studies focus on topological characteristics brain underlying extremely high intelligence intellectual giftedness, particularly in adolescents. Here, we examined topology 25 adolescents with superior (SI-Adol), average (AI-Adol), 27 young adults AI (AI-Adult). We found SI-Adol had properties...
Excessive use of online games can have negative influences on mental health and daily functioning. Although the effects transcranial direct current stimulation (tDCS) been investigated for treatment addiction, it has not evaluated excessive game use. This study aimed to investigate feasibility tolerability tDCS over dorsolateral prefrontal cortex (DLPFC) in gamers.A total 15 gamers received 12 active sessions DLPFC (anodal left/cathodal right, 2 mA 30 min, 3 times per week 4 weeks). Before...
Objective Autophagy is one of the key responses cells to programmed cell death. Memantine, an approved anti-dementia drug, has antiproliferative effect on cancer but mechanism poorly understood. The aim present study was test possibility induction autophagic death by memantine in glioma lines. Methods Glioma lines (T-98 G and U-251 MG) were used for this study. Results shown T-98 cells, which expressed N-methyl-D-aspartate 1 receptor (NMDAR1). Memantine increased autophagic-related proteins...
Negative symptoms represent an unmet need for schizophrenia treatment. The effect of theta frequency transcranial alternating current stimulation (theta-tACS) applied during working memory (WM) tasks on negative has not been demonstrated as yet. We conducted a randomized, double-blind, sham-controlled trial 36 stabilized patients, randomized to receive either twice daily, 6 Hz 2 mA, 20 min sessions in-phase frontoparietal tACS or sham five consecutive weekdays. Participants were concurrently...
Background and Objectives: Attentional dysfunction has long been viewed as one of the fundamental underlying cognitive deficits in schizophrenia. There is an urgent need to understand its neural underpinning develop effective treatments. In process attention, oscillation a central role filtering information allocating resources either stimulus-driven or goal-relevant objects. Here, we asked if resting-state EEG connectivity correlated with attentional performance schizophrenia patients....
There has been an increasing demand for robotic coil positioning during repetitive transcranial magnetic stimulation (rTMS) treatment. Accurate is crucial because rTMS generally targets specific brain regions both research and clinical application with other reasons such as safety, consistency reliability individual variablity. Some previous studies have employed industrial robots or co-robots showed they can more precisely stimulate the target cortical than traditional manual methods. In...
Sodium ozagrel (SO) prevents platelet aggregation and vasoconstriction in the cerebral ischemia. It plays an important role prevention of brain damage induced by ischemia/reperfusion. Recently, many animal studies have suggested that Panax ginseng (PG) has neuroprotective effects ischemic brain. In this study, we assessed come from a combination therapy SO PG rat models with middle artery occlusion (MCAO). Animals MCAO were assigned randomly to one following four groups: (1) control (Con)...
Previous studies have demonstrated a decreased density of dopamine transporters (DAT) in basal ganglia patients with idiopathic Parkinson disease (IPD) using I-n-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (FP-CIT), and the reductions striatal DAT levels were inversely correlated severity motor dysfunction IPD. However, there has been no study on correlation between IPD without cognitive dysfunction. Thus, we evaluated differences regional brain dementia those FP-CIT positron...
Abstract The epigenetic regulation of microRNA (miRNA) expression related to the FK506-binding protein 5 (FKBP5) gene may contribute risk stress-related disorders such as posttraumatic stress disorder (PTSD). Here, we identified candidate miRNAs derived from FKBP5 knockout mice a potential diagnostic biomarker PTSD. Using translational approach, found alter in within medial prefrontal cortex were selected. Each miRNA was examined serum 48 recently traumatized individuals with PTSD and 47...
In this study, we investigated whether gongjin-dan improves functional recovery and has neuroprotective effects on reducing the infarct volume after transient middle cerebral artery occlusion (MCAo). Infarct was measured using TTC staining glucose utilization by F-18 FDG PET. Functional improvement evaluated with Rota-rod, treadmill, Garcia score test, adhesive removal test. At 14 days MCAo, neuronal cell survival, astrocytes expansion, apoptosis were assessed immunohistofluorescence in...