We investigated the clinical significance of plasma concentrations Epstein-Barr virus (EBV) DNA in patients with advanced nasopharyngeal carcinoma.Ninety-nine biopsy-proven stage III or IV carcinoma and no evidence metastasis (M0) received 10 weekly chemotherapy treatments followed by radiotherapy. Plasma samples from were subjected to a real-time quantitative polymerase-chain-reaction assay. EBV genotypes paired primary tumor compared.Plasma was detectable before treatment 94 99 patients,...

Purpose: Nasopharyngeal carcinoma (NPC) is a radiosensitive and chemosensitive tumor. This randomized phase III trial compared concurrent chemoradiotherapy (CCRT) versus radiotherapy (RT) alone in patients with advanced NPC. Patients Methods: From December 1993 to April 1999, 284 1992 American Joint Committee on Cancer stage IV (M0) NPC were randomly allocated into two arms. Similar dosage fractionation of RT was administered both The investigational arm received cycles chemotherapy...

To investigate the prognostic effect of concentrations and clearance rates plasma EBV DNA in metastatic/recurrent nasopharyngeal carcinoma (NPC).Thirty relapsed four previously nontreated metastatic NPC patients were treated according to consensus guidelines head neck cancer team our hospital (i.v. chemotherapy first, followed by local irradiation boost oral maintenance where applicable). Multiple samples collected during first month chemotherapy. Circulating measured a real-time...

We aimed to investigate the association between smoking, alcoholic consumption, and betel quid chewing with oral cancer in a prospective manner. All male patients age ≥18 years who visited our clinic received an mucosa inspection. Basic data including personal habits were also obtained. A multivariate logistic regression model was utilized determine relevant risk factors for developing cavity cancer. total of 10,657 participants enrolled this study. Abnormal findings found 514 (4.8%). Three...

Abstract BACKGROUND: The objective of this study was to confirm the relation between plasma Epstein‐Barr virus (EBV) DNA (pEBV DNA) load and treatment outcomes after long‐term follow‐up in patients with nasopharyngeal carcinoma (NPC). METHODS: In total, 210 NPC were enrolled, including 99 previously reported 111 new patients. They prospectively received induction chemotherapy plus radiotherapy followed for at least 6 years. these patients, pEBV levels measured before 1 week treatment. viral...

The purpose of this study was to investigate factors associated with carotid blowout in the cervical portion patients head and neck cancer a large cohort.We reviewed identified those blowout. Variables without were compared investigated by logistic regression model.A total 2590 included final analysis 102 (3.9%) developed region. Body mass index (BMI) <22.5 kg/M(2) , primary site hypopharynx or oropharynx, open wound requiring wet dressing, radical dissection, radiation dose ≥70 Gy...

The purpose of this study was to investigate factors associated with osteoradionecrosis (ORN) the mandible bone in a large cohort patients oral cancer.We reviewed medical records cancer and identified those ORN bone. Variables without were compared investigated by logistic regression model.A total 1692 included final analysis 105 (6.2%) developed Primary site, including mouth floor, buccal mucosa, retromolar trigone, or gum, segmental mandibulectomy, radiation dose primary site ≥75 Gy...

We conducted this study to investigate whether formalin fixation is associated with the shrinkage of head and neck cancer specimens.Patients scheduled undergo operation were eligible for enrollment. Fresh specimens measured immediately in operating room, measurements repeated after fixation.A total 100 collected. Nearly half them obtained from oral cavity (n=49), a large majority squamous cell carcinoma (n=69). The average decreases length, width, depth 1.50mm (4.40%), 1.52 mm (6.18%), 0.67...

Abstract We investigated the relationship of different primary subsites together with their pathological features on survival oral cavity squamous cell carcinoma (OCSCC) patients. retrospectively reviewed OCSCC patients and documented demographic data, clinical outcome. The Cox proportional hazard model was used to examine influence various prognosis in cavity. There were totally 1,383 enrolled for final analysis. Perineural invasion had a poor at early stage especially those tongue. In...

Background Fungus-driven inflammation is proposed to play an important role in the pathogenesis of chronic rhinosinusitis (CRS). Previous studies tested efficacy intranasal antifungal agents for patients with nasal polyps. The purpose this study was evaluate amphotericin B (AMB) who have CRS without polyps (CRSsNP). Methods Patients diagnosed CRSsNP were enrolled study. They assigned randomly receive irrigation AMB solution (20 mg 500 mL normal saline) or placebo (yellowish dye 4 weeks....

Background The olfactory loss in patients with chronic rhinosinusitis has been measured by different methods. However, the results have variable and it is not clear whether functional endoscopic sinus surgery (FESS) significantly improves function. This study was performed to evaluate influences of FESS on function using three types tests. Methods Seventy were administered University Pennsylvania Smell Identification Test (UPSIT), a single staircase phenyl ethyl alcohol odor detection...

Abstract BACKGROUND: The authors investigated the clinical implication of plasma Epstein‐Barr virus (EBV) DNA assay and 18 F‐fluoro‐2‐deoxy‐D‐glucose ( F‐FDG) positron emission tomography (PET) in detection recurrent nasopharyngeal carcinoma (NPC). METHODS: Two hundred forty‐five patients with NPC who had previously received treatment were a state remission monitored prospectively using EBV every 3 to 6 months. F‐FDG PET studies obtained when abnormal or clinically suggestive signs...

Significance Currently available smell testing methods can be confounded by the lack of prior experience or insensitivity to odorants used in test. This introduces a source bias into clinical tests aimed at detecting patients with olfactory dysfunction. We have developed that use mixtures 30 molecules average out variability sensitivity individual molecules. Because these an unfamiliar and are nonsemantic, their eliminates differences test performance due familiarity smells words describe...

Abstract Background Olfactory epithelial stem cells hold significant potential for treating olfactory dysfunction by facilitating tissue maintenance and repair. Understanding the inherent qualities of these is crucial optimizing their therapeutic efficacy. Methods samples were collected from patients with deviated nasal septum (DNS) chronic rhinosinusitis (CRS). These cultured to form neurospheres (ONS), which then analyzed neural cell markers, neurotrophic factor production, ability...

Background The 40-item University of Pennsylvania Smell Identification Test (UPSIT) is the most widely used smell test in world. Presently, culturally modified versions this are available 12 languages. This study describes first assessment a prototype traditional Chinese version UPSIT (UPSIT-TC) for administration Taiwan. goals were to determine efficacy specific items testing Taiwanese subjects and establish normative adjustments allow use North American norms. Methods UPSIT-TC administered...