Julien Wen Hsieh
A5021487551- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- Long-Term Effects of COVID-19
- Head and Neck Surgical Oncology
- Infectious Diseases and Mycology
- Respiratory and Cough-Related Research
- Nasal Surgery and Airway Studies
- Foreign Body Medical Cases
- Airway Management and Intubation Techniques
- Ear Surgery and Otitis Media
- Ocular Infections and Treatments
- Antifungal resistance and susceptibility
- Oral and Maxillofacial Pathology
- Essential Oils and Antimicrobial Activity
- Teratomas and Epidermoid Cysts
- Facial Nerve Paralysis Treatment and Research
- RNA and protein synthesis mechanisms
- Venous Thromboembolism Diagnosis and Management
- Acne and Rosacea Treatments and Effects
- Multisensory perception and integration
- Retinal and Optic Conditions
- Head and Neck Anomalies
University of Geneva
2009-2025
University Hospital of Geneva
2013-2024
Hôpital Beau-Séjour
2022
Geneva College
2020-2021
Rockefeller University
2014-2017
Centre Hospitalier de Luxembourg
2013
Abstract Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 chemosensory impairments, such as anosmia. However, these downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, generally lacked quantitative measurements. Here, we report the development, implementation, initial results multilingual, international questionnaire assess self-reported quantity quality perception in 3 distinct modalities (smell, chemesthesis) before...
Abstract In a preregistered, cross-sectional study, we investigated whether olfactory loss is reliable predictor of COVID-19 using crowdsourced questionnaire in 23 languages to assess symptoms individuals self-reporting recent respiratory illness. We quantified changes chemosensory abilities during the course illness 0–100 visual analog scales (VAS) for participants reporting positive (C19+; n = 4148) or negative (C19−; 546) laboratory test outcome. Logistic regression models identified...
Background: Since publication of the original Position Paper on Olfactory Dysfunction in 2017 (PPOD-17), personal and so- cietal burden olfactory disorders has come sharply into focus through lens COVID-19 pandemic. Clinicians, scientists public are now more aware importance olfaction, impact its dysfunction quality life, nutrition, social relationships mental health. Accordingly, new basic, translational clinical research resulted significant pro- gress since PPOD-17. In this updated...
The frequent association between coronavirus disease 2019 (COVID-19) and olfactory dysfunction is creating an unprecedented demand for a treatment of the loss. Systemic corticosteroids have been considered as therapeutic option. However, based on current literature, we call caution using these treatments in early COVID-19-related because: (1) evidence supporting their usefulness weak; (2) rate spontaneous recovery high; (3) well-known potential adverse effects. We encourage randomized...
Significance Currently available smell testing methods can be confounded by the lack of prior experience or insensitivity to odorants used in test. This introduces a source bias into clinical tests aimed at detecting patients with olfactory dysfunction. We have developed that use mixtures 30 molecules average out variability sensitivity individual molecules. Because these an unfamiliar and are nonsemantic, their eliminates differences test performance due familiarity smells words describe...
In this work we used micro-array experiments to determine the role of each nonessential subunit conserved Ccr4-Not complex in control gene expression yeast Saccharomyces cerevisiae . The study was performed with cells growing exponentially high glucose and grown depletion. Specific patterns deregulation were observed upon deletion any given subunit, revealing specificity subunit's function. Consistently, purification through Caf40p by tandem affinity from wild-type or lacking individual...
Abstract Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 chemosensory impairments such as anosmia. However, these downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, generally lacked quantitative measurements, were mostly restricted data from single countries. Here, we report the development, implementation initial results multi-lingual, international questionnaire assess self-reported quantity quality perception in...
A survey of the parasites Pacific herring (Clupea harengus pallasi) off northern California identified 1 species Acanthocephala, Cestoda, 2 Copepoda, and family Digenea, 3 Nematoda, Protozoa. From this survey, Lacistorhynchus dollfusi (Cestoda), Parahemiurus merus (Digenea), Anisakis simplex, Contracaecum sp., Hysterothylacium sp. (Nematoda) were selected as potential tags. Herring collected in Tomales, San Francisco, Monterey bays for following 9 yr examined these select parasites. The...
In chronic rhinosinusitis (CRS), nasal obstruction can often be explained by anatomical deformities, polyps, or congested mucosa. However, in cases with little deformity inflammation, perceived may result from reduced airflow perception caused an alteration of the intranasal trigeminal system. The aim this study was to assess association.
Abstract To improve our understanding of the perception odors, researchers are often required to undertake experimental procedures with users exposed multiple odors in a variety settings, including diagnose smell loss clinics and care homes. Existing tests typically administered using sniffing pens, manually presented patients by highly specialized nurse time-consuming complex testing paradigm. Automated odor delivery devices, such as olfactometer systems, exist but expensive, bulky lab...
Cerebral venous thrombosis (CVT) has usually been ascribed to prothrombotic conditions, oral contraceptives, pregnancy, malignancy, infection, head injury or mechanical precipitants. The case reported here illustrates two rare causes of CVT observed in the same patient: presence antiphospholipid antibodies associated with an asymptomatic cryptogenic organising pneumopathy (COP) which were considered origin cerebral and heparin-induced thrombocytopenia (HIT) was responsible for worsening a...
One of the most prevalent causes olfactory loss includes traumatic brain injury with subsequent shearing axons at level cribriform plate (anterior skull base). Scar tissue this may prevent axonal regrowth toward bulb. Currently, there is no cure for debilitating and often permanent condition. promising therapeutic concept to implant a synthetic scaffold growth factors through plate/scar induce neuroregeneration. The first step goal investigate optimum conditions (growth factors,...
We report the case of a 27‐year‐old female who presented with peculiar story anosmia fluctuating in circadian manner. Olfactory function appeared an hour after breakfast, was normal during daytime, and disappeared early evening. Imaging confirmed chronic rhinosinusitis (CRS). Initial systemic, followed by topical steroid treatment, rapidly sustainably reversed this condition. The olfactory fluctuation paralleled endogenous production. This suggests that slight congestion changes chronically...