A5087576837- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cleft Lip and Palate Research
- Immune cells in cancer
- Cancer Cells and Metastasis
- NF-κB Signaling Pathways
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Cervical Cancer and HPV Research
- Immune Cell Function and Interaction
- Oral Health Pathology and Treatment
- Nuclear Receptors and Signaling
- Macrophage Migration Inhibitory Factor
- Monoclonal and Polyclonal Antibodies Research
- Ubiquitin and proteasome pathways
- Salivary Gland Tumors Diagnosis and Treatment
- S100 Proteins and Annexins
- Oral health in cancer treatment
- Immune Response and Inflammation
University of Mons
2016-2025
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2010
Inserm
2010
Abstract Objectives/Hypothesis: The prevalence of human papillomavirus (HPV) in a clinical series 162 patients with oral squamous cell carcinoma (OSCC) was studied. Furthermore, we analyzed the correlation between immunohistochemical expression p16, p53, epidermal growth factor receptor (EGFR), and HPV status to predict survival OSCC patients. Study Design: Retrospective study. Methods: Paraffin‐embedded samples from (n = 162) were evaluated for presence DNA using both GP5+/GP6+ consensus...
Head and Neck Squamous Cell Carcinomas (HNSCC) are characterized by a large heterogeneity in terms of the location risk factors. For few years now, immunotherapy seems to be promising approach treatment these cancers, but better understanding immune context could allow offer personalized thus probably increase survival HNSCC patients. In this context, we evaluated infiltration FoxP3+ Tregs on 205 human formalin-fixed paraffin-embedded assessed its prognostic value compared other potential...
// Imelda Seminerio 1 , Nadège Kindt Géraldine Descamps Justine Bellier 1, 5 Jérôme R. Lechien Quentin Mat Charles Pottier 2 Fabrice Journé 3 and Sven Saussez 4 Department of Human Anatomy Experimental Oncology, Research Institute for Health Sciences Technology, Faculty Medicine Pharmacy, University Mons, Mons B-7000, Belgium Pathology, C.H.U., SART TILMAN, Liège, Liège 4000, Laboratory Oncology Surgery, Jules Bordet Institute,...
The coronavirus pandemic raging worldwide since December 2019 is caused by the severe acute respiratory syndrome 2 (SARS-CoV-2), which invades human cells via angiotensin-converting enzyme (ACE2) receptor. Although it has already been identified in many organs, ACE2 expression remains largely unknown head and neck (HN) sphere. Thus, this study aims to investigate its protein several sites of upper aerodigestive tract order highlight potential routes infection. We compared immunohistochemical...
Despite the advent of concomitant chemoradiotherapy (CCRT), prognosis advanced head and neck squamous cell carcinoma (HNSCC) patients remains particularly poor. Classically, HNSCC, especially oropharyngeal carcinomas, associated with human papillomavirus (HPV) exhibits better treatment outcomes than HNSCCs in non-infected patients, eliciting a call for de-escalation current therapies. To improve management HNSCC we aimed to determine impact active HPV infection on patient response,...
We assessed immune cell infiltrates to develop an immunoscore for prognosis and investigate its correlation with the clinical data of patients head neck cancer. CD8, FoxP3, CD68 markers were evaluated by immunohistochemistry in 258 carcinoma samples positive cells counted stromal intra-tumoral compartments. The RStudio software was used assess optimal cut-offs divide population according survival while prognostic value established using Kaplan–Meier curves Cox regression models each marker...
The head and neck tumor microenvironment (TME) is highly infiltrated with macrophages. More specifically, tumor-associated macrophages (TAM/M2-like) are one of the most critical components associated poor overall survival in cancers (HNC). Two extreme states macrophage phenotypes described as conducting pro-inflammatory/anti-tumoral (M1) or anti-inflammatory/pro-tumoral (M2) activities. Moreover, specific metabolic pathways well oxidative stress responses tightly their functions. Hence, due...
Tumor-associated macrophages are key components of the tumor microenvironment and play important roles in progression head neck cancer, leading to development effective strategies targeting immune cells tumors. Our study demonstrated prognostic potential a new scoring system (Macroscore) based on combination ratio sum high low densities M1 (CD80+) M2 (CD163+) series cancer patients, including training population (n = 54) validation 19). Interestingly, Macroscore outperformed TNM criteria p16...
Objective The aim of this study was to determine the prevalence human papillomavirus (HPV) in 80 tumor‐free tonsils from healthy children and adults using a sensitive E6/E7 type‐specific polymerase chain reaction (PCR). Study Design Cross‐sectional study. Setting Ear, nose, throat department, university hospital. Subjects Methods Paraffin‐embedded tissues (TFTs) were evaluated for HPV DNA GP5+/6+ consensus PCR subsequent genotyping types 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58,...
Human papilloma virus (HPV) infection has been well-established as a risk factor in head and neck squamous cell carcinoma (HNSCC). The carcinogenic effect of HPV is mainly due to the E6 E7 oncoproteins, which inhibit functions p53 pRB, respectively. These oncoproteins could also play role Warburg effect, thus favoring tumor immune escape. Here, we demonstrated that pro-inflammatory cytokine macrophage migration inhibitory (MIF) expressed at higher levels HPV-negative patients than...
Human papillomavirus (HPV) was recently recognized as a new risk factor for head and neck squamous cell carcinoma. For oropharyngeal cancers, an HPV+ status is associated with better prognosis in subgroup of nonsmokers nondrinkers. However, HPV infection also involved the biology carcinoma (HNC) patients history tobacco use and/or alcohol consumption. Thus, involvement HN carcinogenesis remains unclear, further studies are needed to identify analyze HPV-specific pathways that this process....
The incidence of oropharyngeal cancers (OPSCCs) has continued to rise over the years, mainly due human papillomavirus (HPV) infection. Although they were newly reclassified in last TNM staging system, some groups still relapse and have poor prognoses. Based on their implication oncogenesis, we investigated density cytotoxic regulatory T cells, macrophages, Langerhans cells relation p16 status, survival patients. Biopsies from 194 OPSCCs analyzed for HPV by RT-qPCR immunohistochemistry, while...
Bufalin, a cardiotonic steroid derived from the Chinese toad (Bufo gargarizans), has demonstrated potent anticancer properties across various cancer types, positioning it as promising therapeutic candidate. However, comprehensive mechanistic studies specific to head and neck cancers have been lacking. Our study aimed bridge this gap by investigating bufalin’s mechanisms of action in cells. Using several methods, such Western blotting, immunofluorescence, flow cytometry, we observed...