A5071038324- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Pharmacological Effects and Assays
- Exercise and Physiological Responses
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Chemical Sensor Technologies
- Neurobiology and Insect Physiology Research
- Plant-based Medicinal Research
- Ion Channels and Receptors
- Head and Neck Surgical Oncology
- Congenital heart defects research
- Multisensory perception and integration
- Acoustic Wave Phenomena Research
- Neurogenesis and neuroplasticity mechanisms
- Nasal Surgery and Airway Studies
- Pain Mechanisms and Treatments
University of Geneva
2020-2024
University of Zurich
2022
Proper sensing of ambient temperature is utmost importance for the survival euthermic animals, including humans. While considerable progress has been made in our understanding sensors and transduction mechanisms, higher-order neural circuits processing such information are still only incompletely understood. Using intersectional genetics combination with circuit tracing functional neuron manipulation, we identified Kcnip2-expressing inhibitory (Kcnip2GlyT2) interneurons mouse spinal dorsal...
Nearly 460 million individuals are affected by sensorineural hearing loss (SNHL), one of the most common human sensory disorders. In mammals, is permanent due to lack efficient regenerative capacity epithelia and spiral ganglion neurons (SGN). Sphere-forming progenitor cells can be isolated from mammalian inner ear give rise specific cell types in vitro. However, self-renewing capacities auditory neuronal compartment limited few passages, even after adding powerful growth factor cocktails....
One of the most prevalent causes olfactory loss includes traumatic brain injury with subsequent shearing axons at level cribriform plate (anterior skull base). Scar tissue this may prevent axonal regrowth toward bulb. Currently, there is no cure for debilitating and often permanent condition. promising therapeutic concept to implant a synthetic scaffold growth factors through plate/scar induce neuroregeneration. The first step goal investigate optimum conditions (growth factors,...
Many patients complain about olfactory fluctuation (OF), which is a symptom commonly attributed to sinonasal disease. Data-based evidence for its association with disease scarce. The aim of the study identify explanatory variables associated OF and analyze predictive value regarding disease.We performed retrospective based on dysfunction.We analyzed data from 482 attending smell taste outpatient clinic full psychophysical workup structured questions their symptoms. questionnaire included...
Chemosensory dysfunction (olfaction, taste, and trigeminal) affects quality of life, potentially impacting eating behaviors. We investigated which factors are associated with weight loss in patients smell taste disorders.
Objective To investigate the impact of cerebellopontine angle (CPA) masses on subjective and measured taste function. Study Design Retrospective cross-sectional study. Setting Tertiary referral center. Patients Consecutive adult patients with untreated CPA masses. Interventions Gustatory function was psychophysically Taste Strips (range, 0–16) both sides tongue. Subjective complaints were assessed using a questionnaire. Main Outcome Measures Half-sided impairment (hemi-ageusia) defined as...
Hearing loss affects over 460 million people worldwide and is a major socioeconomic burden. Both genetic environmental factors (i.e., noise overexposure, ototoxic drug treatment ageing), promote the irreversible degeneration of cochlear hair cells associated auditory neurons, leading to sensorineural hearing loss. In contrast birds, fish amphibians, mammalian inner ear virtually unable regenerate due limited stemness progenitors, no causal able prevent or reverse As today, main limitation...
BACKGROUND: Although most patients with post-traumatic olfactory dysfunction (PTOD) undergo MRI, there is no consensus about its diagnostic or prognostic value. The aims were: 1) to classify the extent of neurodegeneration; 2) determine relationship chemosensory (smell, taste, trigeminal); and 3) establish whether MRI can predict improvement. METHODOLOGY: We conducted a retrospective cohort study based on series 56 PTOD. All underwent validated psychophysical tests their smell, trigeminal...