A5084531647- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Asthma and respiratory diseases
- Regulation of Appetite and Obesity
- IL-33, ST2, and ILC Pathways
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Adipose Tissue and Metabolism
- RNA and protein synthesis mechanisms
- Sinusitis and nasal conditions
- Culinary Culture and Tourism
- Helicobacter pylori-related gastroenterology studies
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Natural Antidiabetic Agents Studies
- Meat and Animal Product Quality
- Pharmacological Effects of Natural Compounds
- Respiratory and Cough-Related Research
- Drug-Induced Adverse Reactions
- Animal Behavior and Welfare Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Selenium in Biological Systems
Monell Chemical Senses Center
2015-2025
Hangzhou Medical College
2024
University of Bonn
2005-2006
Abstract Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 chemosensory impairments, such as anosmia. However, these downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, generally lacked quantitative measurements. Here, we report the development, implementation, initial results multilingual, international questionnaire assess self-reported quantity quality perception in 3 distinct modalities (smell, chemesthesis) before...
Abstract In a preregistered, cross-sectional study, we investigated whether olfactory loss is reliable predictor of COVID-19 using crowdsourced questionnaire in 23 languages to assess symptoms individuals self-reporting recent respiratory illness. We quantified changes chemosensory abilities during the course illness 0–100 visual analog scales (VAS) for participants reporting positive (C19+; n = 4148) or negative (C19−; 546) laboratory test outcome. Logistic regression models identified...
Abstract The bitter taste of medicines hinders patient compliance, but not everyone experiences these difficulties because people worldwide differ in their bitterness perception. To better understand how from diverse ancestries perceive and modifiers, 338 adults, European recent US Canadian immigrants Asia, South Africa, rated the intensity solutions on a 100-point generalized visual analog scale provided saliva sample for genotyping. were five medicines, tenofovir alafenamide (TAF),...
The pore-forming protein perforin-2 facilitates IL-33 release from dendritic cells.
ABSTRACT Sweet taste is a powerful factor influencing food acceptance. There considerable variation in sweet perception and preferences within among species. Although learning homeostatic mechanisms contribute to this taste, much of it genetically determined. Recent studies have shown that the T1R genes contributes within‐ between‐species differences taste. In addition, our ongoing using mouse model demonstrate significant portion sweetener depends on are not involved peripheral processing....
The integumentary (i.e., skin) and gustatory systems both function to protect the human body are a first point of contact with poisons pathogens. These may share similar protective mechanism because, as we show here, taste skin cells express mRNA for bitter ‘taste’ receptors (TAS2Rs). We used gene-specific methods measure from all known receptor genes in adult freshly biopsied samples collected at autopsy Genotype-Tissue Expression project. Human expressed some but not TAS2Rs, those that...
Ulcerative colitis (UC) is a chronic non-specific inflammatory disease involving the mucosa and submucosa of rectum colon. Lindera aggregate (Sims) Kosterm traditional Chinese herb used for thousands years in treatment gastrointestinal diseases. Previously, we have demonstrated that extracts good anti-UC effects, but their pharmacodynamic active components not been fully clarified. Therefore, explored therapeutic effect Linderanine C (LDC), characteristic component aggregata, on UC its...
COVID-19 has heterogeneous manifestations, though one of the most common symptoms is a sudden loss smell (anosmia or hyposmia). We investigated whether olfactory reliable predictor COVID-19. This preregistered, cross-sectional study used crowdsourced questionnaire in 23 languages to assess individuals self-reporting recent respiratory illness. quantified changes chemosensory abilities during course illness using 0-100 visual analog scales (VAS) for participants reporting positive (C19+;...
Abstract Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 chemosensory impairments such as anosmia. However, these downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, generally lacked quantitative measurements, were mostly restricted data from single countries. Here, we report the development, implementation initial results multi-lingual, international questionnaire assess self-reported quantity quality perception in...
Alpha-actinins (ACTN1 and ACTN4) gamma-actin (ACTG2), were investigated as candidate genes on the basis of their known functions, for possible association with sperm concentration, motility, semen volume per ejaculate, plasma droplets rate, abnormal rate fertility traits, non-return number piglets born alive. Polymorphisms identified in intron 18 (G>A) porcine ACTN1 gene exon 22 (A>C) ACTN4 by comparative sequencing animals from Pietrain (PI) Hampshire (HA) breeds. (n = 244) crossbreed PI x...
Host defense at the mucosal interface requires collaborative interactions between diverse cell lineages. Epithelial cells damaged by microbial invaders release reparative proteins such as Trefoil factor family (TFF) peptides that functionally restore barrier integrity. However, whether TFF and their receptors also serve instructive roles for immune function during infection is incompletely understood. Here, we demonstrate intestinal trefoil factor, TFF3, restrains (T helper) T
T2R bitter receptors, encoded by
Obesity is a heritable trait caused by complex interactions between genes and environment, including diet. Gene-by-diet are difficult to study in humans because the human diet hard control. Here, we used mice dietary obesity genes, four methods. First, bred 213 F2 from strains that susceptible [C57BL/6ByJ (B6)] or resistant [129P3/J (129)] obesity. Percent body fat was assessed after ate low-energy again same high-energy for 8 weeks. Linkage analyses identified QTLs associated with Three...
Retinol-binding protein 4 (RBP4), androgen receptor (AR), relaxin (RLN), acrosin (ACR) and osteopontin (polymorphism in intron 6 named OPNin6; polymorphism promoter region OPNprom) were addressed as functional candidate genes for sperm quality boar fertility investigated their association with concentration, motility, semen volume per ejaculate, plasma droplets rate, abnormal spermatozoa rate well non-return number of piglets born alive. Therefore 356 AI boars the purebred Pietrain (PI)...
Bitter and sweet taste receptors are present in the human upper airway, where they have roles innate immunity. Previous studies shown that 1 of 25 bitter receptors, TAS2R38, responds to specific bacterial signaling molecules evokes type a defense response whereas ligands suppress other types responses.We examined whether might also be involved immunity by using sensory responses compounds not TAS2R38 (quinine denatonium benzoate) assess sensitivity chronic rhinosinusitis (CRS) patients. CRS...
SCENTinel, a rapid smell test designed to screen for olfactory disorders, including anosmia (no ability an odor) and parosmia (distorted sense of smell), measures 4 components function: detection, intensity, identification, pleasantness. Each card contains one 9 odorant mixtures. Some people born with genetic insensitivities specific odorants (i.e. anosmia) may fail the if they cannot but otherwise have normal smell. However, using mixtures has largely been found prevent this from happening....
TAS2R38 is a human bitter receptor gene with common but inactive allele; people homozygous for the form cannot perceive low concentrations of certain compounds. The frequency and active forms this nearly equal in many populations, heterozygotes 1 copy have most diplotype. However, even though they same genotype, differ markedly their perception bitterness, perhaps part because differences mRNA expression. Other tissues express too, including nasal sinuses, where it contributes to pathogen...