A5025306036- Inflammatory Bowel Disease
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Estrogen and related hormone effects
- Aldose Reductase and Taurine
- Gut microbiota and health
- Topic Modeling
- Cancer, Hypoxia, and Metabolism
- Hearing Loss and Rehabilitation
- Traditional Chinese Medicine Studies
- Cytomegalovirus and herpesvirus research
- Explainable Artificial Intelligence (XAI)
- Technology Assessment and Management
- Cancer-related Molecular Pathways
- Tryptophan and brain disorders
- Adenosine and Purinergic Signaling
- Immune Response and Inflammation
- Drug-Induced Hepatotoxicity and Protection
- IL-33, ST2, and ILC Pathways
- Prenatal Substance Exposure Effects
- Heavy Metal Exposure and Toxicity
- Industrial Technology and Control Systems
- Image Enhancement Techniques
- Heme Oxygenase-1 and Carbon Monoxide
Rensselaer Polytechnic Institute
2021-2024
Hangzhou Medical College
2021-2024
Zhejiang Academy of Medical Sciences
2016-2021
Chiayi Chang Gung Memorial Hospital
2021
Zhejiang Chinese Medical University
2018-2019
Hangzhou Xixi hospital
2017
State Council of the People's Republic of China
2017
National Science Library
2012
National Chiayi University
2008-2011
Xi'an University of Technology
2006
Ulcerative colitis (UC) is a chronic non-specific inflammatory disease involving the mucosa and submucosa of rectum colon. Lindera aggregate (Sims) Kosterm traditional Chinese herb used for thousands years in treatment gastrointestinal diseases. Previously, we have demonstrated that extracts good anti-UC effects, but their pharmacodynamic active components not been fully clarified. Therefore, explored therapeutic effect Linderanine C (LDC), characteristic component aggregata, on UC its...
Traditional treatments have a poor effect on alcoholic liver diseases. Linderae radix (LR), the dried root of Lindera aggregata (Sims) Kosterm., has been frequently used in traditional Chinese medicine for treating various diseases, and shown to exhibit protective injury. In present study, LR extracts were made using solvents, then administrated rats establish model ethanol‑induced The study aimed investigate therapeutic effects potential mechanism acute serum levels alanine aminotransferase...
Ulcerative colitis (UC) is a chronic, idiopathic and relapsing inflammatory disease of the gastrointestinal tract that has prolonged duration. Lindera aggregata (Sims) Kosterm. traditional Chinese herb which been used to treat diseases for thousand years. However, there are few reports about application L. in treatment UC at present. Herein, we investigated therapeutic effect root extract (LREE) against explored its underlying mechanisms based on IL-6 signaling pathway balance T helper (Th)...
Peach gum is a homologous substance of medicine and food, mainly composed polysaccharides. This study aimed to investigate the effectiveness polysaccharides (PGP) in treatment ulcerative colitis (UC) explore its mechanisms. Firstly, we found PGP could decrease disease activity index, increase length shortened colon improve colonic tissue lesions UC observably vivo. Further, explored mechanisms anti-UC from aspects immune regulation intestinal barrier. On one hand, significantly alleviate...
The present study was performed to determine whether Lycium barbarum polysaccharides (LBPs) would protect mice against cadmium (Cd)-induced testicular toxicity. Seventy-two male were randomly divided into six groups with twelve per group. Four administered orally chloride (5.0 mg kg body weight) for 35 days and treated in combination LBPs (0, 10.0, 33.3 or 100 kg-1) from one week before exposure Cd until the end of experiment. other two vehicle LBP (100 only. Pretreatment ameliorated...
Cytochrome P450 1a1 (Cyp1a1) is a phase I xenobiotic-metabolizing enzyme, the expression of which mainly driven by aryl hydrocarbon receptor (AhR). Cyp1a1 messenger (m)RNA labile. Our study indicates that 1-nitropyrene (1-NP) highly induced protein expression, although its induction AhR transactivation activity was negligible. The fact nuclear receptors, CAR, FXR LXR, or PXR, did not induce they do mediate 1-NP's action. When transcript degraded small hairpin (sh)RNA-AhR, 1-NP-induced...
Sesquiterpene lactones are bioactive compounds that have been identified as responsible for the anticancer activity of medicinal herb, Inula helenium L. (IHL). However, mechanisms action involved in anti‑pancreatic cancer IHL yet to be elucidated. The present study used an optimized extraction strategy obtain sesquiterpene from (the resulting product termed ethyl acetate extract IHL; EEIHL), and examined potential EEIHL. Ethanol were give final Cell Counting Kit‑8, colony formation Annexin...
Abstract Prostate cancer is a major cause of death in males. Cyproterone acetate (CPA), the steroidal anti-androgen for part androgen deprivation therapy, may block androgen-receptor interaction and then reduce serum testosterone through its weak anti-gonadotropic action. In addition to CPA inducing hepatitis, known liver tumors rats also. Aryl hydrocarbon receptor (AhR) cytoplasmic regulates multiple physiological functions. CYP1A1 an AhR-targeted gene. We found that induced expression,...
In standard nonclinical drug safety evaluation studies, limitations exist in predicting the clinical risk of a based only on data from healthy animals. To obtain more comprehensive toxicological information norisoboldine (NOR), we conducted an exploratory study using C57BL/6 mice addition to as models dextran sodium sulfate (DSS) colitis evaluate NOR. The and DSS were exposed 30 or 90 mg NOR/kg body weight water for 15 days. Compared with model control group, mg/kg NOR aggravated symptoms...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), 1-nitropyrene (1-NP), and benzo[a]pyrene (BaP) are toxic environmental pollutants. TCDD was shown to suppress p53 expression in response genotoxic stress hypoxic conditions. However, the mechanism of TCDD's actions is not clearly understood. Our data showed that pretreatment with abolished 1-NP- but BaP-induced mouse double minute 2 (MDM2; HDM2 humans) expressions. suppressed activity, contrast, pifithrin-alpha (PFT-α), a inhibitor, both activity....
This article aims to investigate the ameliorative effect of Linderae Radix ethanol extract on hyperlipidemia rats induced by high-fat diet and explore its possible mechanism from perspective reverse cholesterol transport(RCT). SD were divided into normal group, model atorvastatin extract(LREE) high, medium, low dose groups. Except for other groups fed with a establish rat models; group given pure water, while each administration was corresponding drugs gavage once day five weeks. Serum total...
Pipeline parallelism is an essential technique in the training of large-scale Transformer models. However, it suffers from imbalanced memory consumption, leading to insufficient utilization. The BPipe was proposed address this issue and has proven effective GPT-3 model. Nevertheless, our experiments have not yielded similar benefits for LLaMA training. Additionally, only yields negligible when applying flash attention. We analyze underlying causes divergent performance on LLaMA. Furthermore,...
Quantization is a proven effective method for compressing large language models. Although popular techniques like W8A8 and W4A16 effectively maintain model performance, they often fail to concurrently speed up the prefill decoding stages of inference. W4A8 promising strategy accelerate both them while usually leads significant performance degradation. To address these issues, we present QQQ, Quality Quattuor-bit with 4-bit weights 8-bit activations. QQQ employs adaptive smoothing...
Architecture defines various aspects of museum spaces. Despite often being considered secondary importance by some deciders and designers, the acoustic environment significantly shapes interpretation exhibitions human-building interactions. Focusing on enhancing acoustics, this study builds upon previous research that developed a methodology for simulating evaluating soundscapes through psychophysical experiments in immersive environments, showing participants preferred congruent over...
Dynamic activation (DA) techniques, such as DejaVu and MoEfication, have demonstrated their potential to significantly enhance the inference efficiency of large language models (LLMs). However, these techniques often rely on ReLU functions or require additional parameters training maintain performance. This paper introduces a training-free Threshold-based Activation(TDA) method that leverage sequence information exploit inherent sparsity across various architectures. is designed accelerate...
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, which increases incidence colorectal cancer (CRC). In pathophysiology IBD, ubiquitination/deubiquitination plays critical regulatory function. Josephin domain containing 2 (JOSD2), deubiquitinating enzyme, controls cell proliferation and carcinogenesis. However, its role in IBD remains unknown. Colitis mice model developed by dextran sodium sulfate (DSS) or colon tissues from individuals with...
According to the J2EE criteria, a framework based on middleware technique and model-view controller (MVC) design pattern are introduced establish flood control system in Web domain which flexible enough for future extension, algorithm improvement upgrade with new hydrologic models. The Xinanjiang tank models adopted as hydrological investigate applicability of proposed technology. Components forecasting were developed under an IE browser. was tested small watershed it is indicates that model...
To observe the effects of three traditional Chinese medicine (TCM) such as Amomi Fructus Rotundus, Perillae Folium and Angelicae Dahuricae Radix on lung-yang deficiency rats induced by compound factors.Lung-yang were established with three-factor combination, smoking (exogenous evil effect lung), swimming in common ice water (cold body exhaustoin) drinking (inhale cold). Meanwhile, given extracts TCM intragastric administration for 24 days everyday. Indexes general behavior, weight, rectal...