A5103104210- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- interferon and immune responses
- Natural product bioactivities and synthesis
- Alcohol Consumption and Health Effects
- Polysaccharides and Plant Cell Walls
- Flavonoids in Medical Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Morinda citrifolia extract uses
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Pneumonia and Respiratory Infections
- RNA Interference and Gene Delivery
- Multiple and Secondary Primary Cancers
- Pregnancy and preeclampsia studies
- Bone and Joint Diseases
- COVID-19 Clinical Research Studies
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 and healthcare impacts
Zhejiang Provincial People's Hospital
2020-2024
Hangzhou Medical College
2020-2024
The First People's Hospital of Tianmen
2016-2022
Nanjing University
2014-2016
Nanjing General Hospital of Nanjing Military Command
2015-2016
Southern Medical University
2012-2015
Podocyte migration is actively involved in the process of podocyte loss and proteinuria production, which closely associated with development diabetic nephropathy (DN). Exosomes from adipose-derived stem cells (ADSCs-Exos) effectively inhibit apoptosis treatment DN. However, how ADSCs-Exos affect podocytes obscure. This study aimed at exploring regulatory role on cell underlying mechanism.ADSCs-Exo was authenticated by transmission electron microscopy (TEM), western blotting, flow cytometry....
Traditional treatments have a poor effect on alcoholic liver diseases. Linderae radix (LR), the dried root of Lindera aggregata (Sims) Kosterm., has been frequently used in traditional Chinese medicine for treating various diseases, and shown to exhibit protective injury. In present study, LR extracts were made using solvents, then administrated rats establish model ethanol‑induced The study aimed investigate therapeutic effects potential mechanism acute serum levels alanine aminotransferase...
Acute kidney injury (AKI) poses a severe threat to human health. MicroRNAs (miRNAs/miRs) are known be involved in the progression of AKI; however, function miR‑1184 AKI remains unclear. Thus, aim present study was examine role this miRNA injury. In order mimic vitro, HK‑2 cells were treated with cisplatin. Bioinformatics analysis performed explore differentially expressed miRNAs AKI. A Cell Counting Kit‑8 assay and flow cytometry cell viability apoptosis, respectively. mRNA expression levels...
ObjectiveHalf of the patients with acute large artery occlusion (LAO) have poor outcomes after endovascular treatment (EVT). Early complications such as cerebral edema and symptomatic intracranial hemorrhage (sICH) can lead to early neurological deterioration (END), which correlates hemodynamics. This study aimed identify hemodynamic predictors END in LAO EVT.MethodsA total 76 anterior circulation who underwent EVT received transcranial Doppler (TCD) monitoring were included. Bilateral...
Candida krusei (C. krusei) pneumonia is a rare infection that frequently associated with poor outcome. The present study reports an unusual case of C. was initially suspected to be Middle East respiratory syndrome (MERS) case. A 64-year-old Saudi Arabian male patient admitted our hospital complaints cough and dyspnea persisted for 6 days. presented fever (oral temperature, 38.5°C) slight tachypnea (25 respirations/min). chest computerized tomography demonstrated unclear lung fields, diffuse...
The 2009 influenza pandemics underscored the need for effective vaccines to block spread of virus infection. Most live attenuated utilize cold-adapted, temperature-sensitive virus. An alternative is presented here, based on microRNA-induced gene silencing.In this study, miR-let-7b target sequences were inserted into H1N1 genome engineer a recombinant - miRT-H1N1. Female BALB/c mice vaccinated intranasally with miRT-H1N1 and challenged lethal dose homologous virus.This was in mice, while it...
Evaluating the attenuation of influenza viruses in animal studies is important developing safe and effective vaccines. This study aimed to demonstrate that microRNA (miRNA)-let-7b-mediated attenuated (miRT-H1N1) are sufficiently mice.The pathogenicity miRT-H1N1virus was investigated a mouse model, evaluated with median lethal dose (LD50). The replicative dynamics miRT-H1N1, wild type (wt)-H1N1, scramble (scbl)-H1N1 lungs infected mice were compared. degrees lesions expression levels IL-6,...
This study is an attempt to evaluate the therapeutic effect of ethanolic extract Lindera aggregata on liver and intestinal microbiota in rats with alcohol-induced injury (ALI). Rats were treated 70 mg probiotics, 1 g/kg, 2 3 g/kg aggregata, respectively, for 10 days. We found that could significantly reduce biochemical parameters serum ALD rats. alleviates oxidative stress inflammation by upregulating SIRT1 Nrf2 downregulating COX2 NF-κB. The results 16S rRNA gene sequencing showed medium...
Since December 2019, there have been many new cases of coronavirus pneumonia in Wuhan, Hubei Province, which has gradually spread throughout the country.To explore our hospital's innovative management system to ensure efficient operation fever clinics during epidemic, since controlling disease is an important way prevent and control epidemic.In total, 200 outpatients with at hospital between November 2019 July 2020 were selected allocated into two groups.The clinic operated smoothly,...