A5100599586- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Ovarian cancer diagnosis and treatment
- Rheumatoid Arthritis Research and Therapies
- Inflammatory Myopathies and Dermatomyositis
- Traditional Chinese Medicine Studies
- T-cell and B-cell Immunology
- Plant-based Medicinal Research
- Mycobacterium research and diagnosis
- Dermatological and Skeletal Disorders
- Airway Management and Intubation Techniques
- Immune responses and vaccinations
- Salivary Gland Disorders and Functions
- Hepatitis C virus research
- Intraperitoneal and Appendiceal Malignancies
- Diagnosis and treatment of tuberculosis
- IL-33, ST2, and ILC Pathways
- Bacteriophages and microbial interactions
- Children's Physical and Motor Development
- Cancer-related molecular mechanisms research
- Thermal Regulation in Medicine
- Systemic Sclerosis and Related Diseases
- Endometrial and Cervical Cancer Treatments
- Neurological Disease Mechanisms and Treatments
- Tracheal and airway disorders
ShenZhen People’s Hospital
2025
Jinan University
1999-2024
Wenzhou Medical University
2024
Southern University of Science and Technology
2020-2024
China Agricultural University
2022-2024
Weifang People's Hospital
2023
Taipei Veterans General Hospital
2017-2022
University of Science and Technology of China
2019-2022
Southern Medical University
2022
Zhongshan People's Hospital
2022
This study aimed to investigate the microbiological characteristics, antimicrobial resistance profiles, antibiotic choice, and outcomes of Nocardia infection in various centers over a 7-year period (from 2015 2021).We retrospectively analyzed medical records all hospitalized patients diagnosed with between 2021. The isolates were identified species level through sequencing 16S ribosomal RNA or secA1 ropB genes. susceptibility profiles determined using broth microdilution method.Of 130...
Background: Gestational diabetes mellitus (GDM) is a metabolic disorder that arises during pregnancy and heightens the risk of placental dysplasia. Ginsenoside Re (Re) may stabilize insulin glucagon to regulate glucose levels, which improve diabetes-associated diseases. Purpose: This study aims investigate mechanism in high (HG)-induced apoptosis trophoblasts through endoplasmic reticulum stress (ERS)-related protein CHOP/GADD153. Research Design: Human trophoblast cells HTR-8/SVneo were...
Objectives This research aims to reveal the mechanisms of effect Paraoxonase 1 ( PON1 ) gene on response leflunomide (LEF) in rheumatoid arthritis (RA) patients, terms single nucleotide polymorphism (SNP), DNA methylation levels. Methods A total 240 RA patients enrolled were categorized into good group and non-response according difference DAS28 scores between baseline 6 months after LEF administration. The identified LEF-response cytosine-phosphate-guanines (CpGs) island (cg17330251) its...
Objective To study the etiology of recurrent and persistent wheezing in infants toddlers, identify risk factors for infantile asthma. Methods We retrospectively analyzed data 612 children (aged 0–36 months) hospitalized or between 2019.09.01 2022.08.31. comparatively their clinical, laboratory, imaging, lung-examination different groups. Multivariate logistic regression analysis was used to Results The etiologies significantly differed ( P < 0.05). top 3 causes were viral infections...
Dermatomyositis and polymyositis (DM/PM) are systemic autoimmune diseases characterized by proximal muscle weakness. The underlying pathogenetic mechanism of this disease remains under-researched. Here, using proteomics analysis, a great overlap differentially expressed plasma exosomal proteins involved in the complement coagulation cascade pathway, including FGA, FGB, FGG, C1QB, C1QC, VWF, was identified DM/PM patients versus healthy controls. Correlation analysis showed that expression...
Accumulating evidence indicates that antibodies can protect against some intracellular pathogens. Mycobacterium bovis is an bacterium, and its cell wall (CW) essential for virulence survival. However, the questions of whether play a protective role in immunity M. infection what effects specific to CW have still remain unclear. Here, we report targeting isolated pathogenic strain attenuated bacillus Calmette-Guérin (BCG) could induce protection virulent
Respiratory mucosal immunization is an effective strategy against tuberculosis (TB), and vaccines require adjuvants that can promote protective immunity without deleterious inflammation. Mucosal BCG (Bacille Calmette-Guerin) effective, but it causes a severe inflammatory response in the lung. A novel less cytotoxic vaccine AH-PB containing Mycobacterium (Mtb) cell surface antigens Ag85A HspX (AH), as well polyinosinic-polycytidylic acid (Poly IC) bovine neutrophil β-defensin-5 (B5) were...
Background Autoimmune thyroid disease (AITD), which is characterized by an increased presence of autoantibodies (TAbs), such as antibodies against peroxidase (TPOAbs) and thyroglobulin (TgAbs), has been reported to be associated with rheumatoid arthritis (RA) because AITD RA both involve autoimmunity. However, few data are available on the incidence TAbs in Chinese patients, studies association between joint damage well synovitis patients remain sparse. Here, we aimed evaluate a consecutive...
Previous studies have revealed that hepatitis B virus (HBV) infection may be related to rheumatoid arthritis (RA), but there are no on the presence of HBV antigens or nucleic acid in synovium from patients with RA infection. In present study, we investigated and its clinical significance RA. Fifty-seven consecutive active (Disease Activity Score 28-joint assessment based C-reactive protein ≥ 2.6) available synovial tissue who had completed 1 year follow-up were recruited a prospective...
To compare the performance of clinical factors, FS-T2WI, DWI, T1WI+C based radiomics and a combined clinic-radiomics model in predicting type serous ovarian carcinomas (SOCs).In this retrospective analysis, 138 SOC patients were confirmed by histology. Significant factors (P < 0.05, with area under curve (AUC) > 0.7) was retained to establish model. The included T1WI+C, also, multisequence established. A total 1,316 features each sequence extracted; univariate multivariate logistic...
Laser tweezers Raman spectroscopy enables multiplexed, quantitative chemical and morphological analysis of individual bionanoparticles such as drug-loaded nanoliposomes, yet it requires minutes-scale acquisition times per particle, leading to a lack statistical power in typical small-sized data sets. The long present bottleneck not only measurement time but also the analytical throughput, particle concentration (and thus throughput) must be kept low enough avoid swarm measurement. effective...
Background Previous studies have revealed that Galectin-9 (Gal-9) acts as an apoptosis modulator in autoimmunity and rheumatic inflammation. In the present study, we investigated potential role of Gal-9 a biomarker patients with rheumatoid arthritis (RA), especially indicator functional limitations radiographic joint damage. Methods A total 146 RA 52 age- sex-matched healthy controls were included this study. Clinical data including disease activity, physical function, damage assessed....
Objective structured clinical examinations (OSCEs) have been administered in physical and psychiatric occupational therapy (OT) education, but not pediatric OT education. The objectives were to examine the satisfaction influences of OSCE on all participants.The contained evaluation, intervention, parent education stations. Sixty examinees, 44 child standardized patients (SPs), chaperones, three playroom managers, 14 assistants, 15 examiners participated OSCE. An video playrooms prepared for...
Hypoxia-inducible factor-1α (HIF-1α) is a pivotal regulator of metabolic and inflammatory responses. This study investigated the role HIF-1α in Mycobacterium bovis infection its effects on host immune metabolism tissue damage. We evaluated expression immunometabolism markers matrix metalloproteinases (MMPs) cells infected with M. bovis, following inhibition vitro. To understand implications disease progression, mice at different stages were treated inhibitor, YC-1. Our results revealed an...
The role of gut microbiota has been described as an important influencer the immune system. Gut-lung axis is critical in prevention mycobacterium infection, but specific mechanism, by which dysbiosis affects tuberculosis, not reported. In this study, we attempted to provide more information on how gut-lung contributes Mycobacterium bovis (M. bovis) infection. Mice are pre-treated with broad-spectrum antibiotics cocktail (Abx) induce dysbiosis. Interestingly, microbes showed a significant...
Early identification of young children at risk developmental coordination disorder (DCD) can support early intervention and prevent secondary sequelae.To examine the psychometric properties a translated cross-culturally adapted version Little Developmental Coordination Disorder Questionnaire-Taiwan (LDCDQ-TW).Prospective study.Kindergartens preschools in north, central, south Taiwan.In Phase 1 participants were 1,124 parents typically developing ages 36-71 mo. Children with confirmed...
Background Magnetic resonance imaging (MRI) is a significant method of identifying ovarian tumors, when combined with certain functional techniques that have been considered to be more accurate. Purpose Our study aims determine the value diffusion-weighted (DWI) MRI in diagnosis thecomas and adult granulosa cell tumors (GCTs). Material Methods In total, this included 10 patients nine GCTs. We analyzed clinical characteristics, conventional MRI, apparent diffusion coefficient (ADC) values two...
The Janus kinases (JAKs) are intracellular tyrosine involved in a broad variety of inflammatory cascades participating the pathogenesis systemic lupus erythematosus (SLE). Diffuse non-scarring alopecia is one most frequent cutaneous manifestations SLE, resulting devastating psychosocial consequences. Although recent studies have shown promising outcomes JAK inhibitors SLE treatment, efficacy tofacitinib diffuse due to has never been reported. Here we present 29-year-old patient with 10-year...
Dermatomyositis occurs extremely rarely during pregnancy. A number of studies in the published literature have documented how outcome pregnancy is poor for both mother and fetus. The present case study reports on a patient who was diagnosed with clinically amyopathic dermatomyositis complicated by interstitial lung disease pregnancy, successfully treated combined immunosuppressant regimen. To best authors’ knowledge, this first detailing pregnant woman positive anti-melanoma...
Since the second half of 20th century, Aedes albopictus, a vector for more than 20 arboviruses, has spread worldwide. albopictus is main infectious diseases transmitted by mosquitoes in China, and it caused concerns regarding public health. A comprehensive understanding spatial genetic structure this species at genomic level essential effective control prevention vector-borne diseases. During 2016-2018, adult female Ae. were collected from eight different geographical locations across China....