A5070152146- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Ubiquitin and proteasome pathways
- Quality Function Deployment in Product Design
- Autophagy in Disease and Therapy
- Customer Service Quality and Loyalty
- Cancer-related Molecular Pathways
- Consumer Retail Behavior Studies
- Cancer-related molecular mechanisms research
- Forest, Soil, and Plant Ecology in China
- Effects and risks of endocrine disrupting chemicals
- Acute Myeloid Leukemia Research
- Energetic Materials and Combustion
- Drug Transport and Resistance Mechanisms
- Quality and Supply Management
- RNA Research and Splicing
- Silicon Carbide Semiconductor Technologies
- Multi-Criteria Decision Making
- Pharmacogenetics and Drug Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Metal-Organic Frameworks: Synthesis and Applications
- Technology and Data Analysis
- Synthesis and Biological Evaluation
- Advancements in Semiconductor Devices and Circuit Design
- Aldose Reductase and Taurine
Institute of Biological Chemistry, Academia Sinica
2019-2023
National Taiwan University
2019
National Chiayi University
2009-2016
Yu Da University
2014
Taiwan Semiconductor Manufacturing Company (Taiwan)
2012
Government of Jilin Province
2005
Long non-coding RNAs (lncRNAs) represent the majority of cellular transcripts and play pivotal roles in hematopoiesis. However, their clinical relevance acute myeloid leukemia (AML) myelodysplastic syndrome (MDS) remains largely unknown. Here, we investigated functions HOXB-AS3, a lncRNA located at human HOXB cluster, cells, analyzed prognostic significances patients with AML MDS.shRNAs were used to downregulate HOXB-AS3 cell lines effect was evaluated by quantitative polymerase chain...
// Chih-Shou Chen 1 , Dong-Ru Ho Fei-Yun 2 Chang-Rong Yu-De Ke Jyan-Gwo Joseph Su Division of Urology, Department Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan, ROC Biochemical Science and Technology, National Chiayi University, 600, Correspondence: Su, email: Keywords : Actinomycin D, AKT, p53 Received August 28, 2013 Accepted January 11, 2014 Published Abstract At high cytotoxic concentrations, actinomycin D (ActD) blocks transcription, decreasing levels MDM2 thus causing...
Abstract Background Autophagy plays important roles in cell homeostasis and protein quality control. Long non-coding RNAs (lncRNAs) have been revealed as an emerging class of autophagy regulators, but the majority them function regulating expression autophagy-related genes. LncRNAs that directly act on core autophagic proteins remain to be explored. Methods Immunofluorescence staining Western blotting were used evaluate BCRP3 aggrephagy. RNA immunoprecipitation vitro RNA–protein binding...
The BH3-only pro-apoptotic protein BIK is regulated by the ubiquitin–proteasome system. However, mechanism of this regulation and its physiological functions remain elusive. Here, we identify Cul5-ASB11 as E3 ligase targeting for ubiquitination degradation. ER stress leads to activation ASB11 XBP1s during adaptive phase unfolded response, which stimulates ubiquitination, interaction with p97/VCP, proteolysis. This degradation contributes adaptation promoting cell survival. Conversely,...
Cytochrome P450 1a1 (Cyp1a1) is a phase I xenobiotic-metabolizing enzyme, the expression of which mainly driven by aryl hydrocarbon receptor (AhR). Cyp1a1 messenger (m)RNA labile. Our study indicates that 1-nitropyrene (1-NP) highly induced protein expression, although its induction AhR transactivation activity was negligible. The fact nuclear receptors, CAR, FXR LXR, or PXR, did not induce they do mediate 1-NP's action. When transcript degraded small hairpin (sh)RNA-AhR, 1-NP-induced...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), 1-nitropyrene (1-NP), and benzo[a]pyrene (BaP) are toxic environmental pollutants. TCDD was shown to suppress p53 expression in response genotoxic stress hypoxic conditions. However, the mechanism of TCDD's actions is not clearly understood. Our data showed that pretreatment with abolished 1-NP- but BaP-induced mouse double minute 2 (MDM2; HDM2 humans) expressions. suppressed activity, contrast, pifithrin-alpha (PFT-α), a inhibitor, both activity....
The study of total quality management (TQM) and how the security industry can impetus processes to promote customer satisfaction loyalty are very few. In practice, priority service providers should be thinking about develop a comprehensive TQM system, understanding needs, reducing frequency gaps achieve loyalty. Therefore, this mainly lies as what angle cuts into, in view negotiable securities entrepreneur whether it affect degree customers’ by way execution. This takes cities Hsin-Chu...
Literature has reported that smartphone user’s satisfaction can differ according to consumer life experiences by using structural equation modelling (SEM). However, SEM seems too complex and difficult for the practitioners, particularly interpretation of numerical estimates each parameters, provided SEM. Recently, decision tree model been used analyze factors affecting satisfaction. Decision trees (DT) represent one simplest often most effective non-parametric supervised learning method...
In this paper, the relation between surface electric field and temperature distribution dependence on drift-region doping concentration in a 30-V asymmetric drain-extended MOSFET is studied. For case of high concentration, drain resistance low, current density high, which induces nonuniform transistor, turn reduces carrier mobility causes negative resistance. low uniform obtained. However, different changes location maximum from gate-overlapped drift region for to drain-side contact under <i...