A5039423401- Biochemical Analysis and Sensing Techniques
- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Synthesis of Organic Compounds
- Respiratory and Cough-Related Research
- Probiotics and Fermented Foods
Monell Chemical Senses Center
2021-2025
Abstract The bitter taste of medicines hinders patient compliance, but not everyone experiences these difficulties because people worldwide differ in their bitterness perception. To better understand how from diverse ancestries perceive and modifiers, 338 adults, European recent US Canadian immigrants Asia, South Africa, rated the intensity solutions on a 100-point generalized visual analog scale provided saliva sample for genotyping. were five medicines, tenofovir alafenamide (TAF),...
SCENTinel, a rapid smell test designed to screen for olfactory disorders, including anosmia (no ability an odor) and parosmia (distorted sense of smell), measures 4 components function: detection, intensity, identification, pleasantness. Each card contains one 9 odorant mixtures. Some people born with genetic insensitivities specific odorants (i.e. anosmia) may fail the if they cannot but otherwise have normal smell. However, using mixtures has largely been found prevent this from happening....
Abstract The bitter taste of medicines hinders patient compliance, but not everyone experiences these difficulties because people worldwide differ in their bitterness perception. To better understand how from diverse ancestries perceive and modifiers, 338 adults, European recent US Canada immigrants Asia, South Africa, rated the intensity solutions on a 100-point generalized visual analog scale provided saliva sample for genotyping. were five medicines, tenofovir alafenamide (TAF),...
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SCENTinel™ - a rapid, inexpensive smell test that measures odor detection, intensity, identification, and pleasantness was developed for population-wide screening of function. previously found to screen multiple types disorders. However, the effect genetic variability on performance is unknown, which could affect test's validity. This study assessed in large group individuals with normal sense determine test-retest reliability heritability performance. One thousand participants (36 [IQR...
Abstract Purpose The bad bitter taste of some medicines is a barrier to overcoming non-compliance with medication use, especially life-saving drugs given children and the elderly. Here we evaluated new class blockers (thiazolidinediones; TZDs). Methods In this study, two TZDs were tested, rosiglitazone (ROSI) simpler form TZD, using high-potency sweetener as positive control (neohesperidin dihydrochalcone, NHDC). We tested bitter-blocking effects tenofovir alafenamide fumarate (TAF),...
Abstract The recovery period from post-COVID-19 smell and taste dysfunctions varies substantially, lasting a few days to over year. We aimed assess the impact of COVID-19 on chemosensory sensitivity in group young convalescents eastern/central European ancestry. measured subjects’ capabilities with standard testing kit, Monell Flavor Quiz (MFQ), collected surveys history. During testing, subjects rated liking intensity six odor samples (galaxolide, guaiacol, beta-ionone, trimethylamine,...
How much pleasure we take in eating is more than just how enjoy the taste of food. Food involvement - amount time spend on food beyond immediate act and tasting key to human experience. We took a biological approach test whether food-related behaviors, together capturing involvement, have genetic components are partly due inherited variation. collected data via an internet survey from genetically informative sample 419 adult twins (114 monozygotic twin pairs, 31 dizygotic 129 singletons)....