A5055372029- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Gut microbiota and health
- Diet, Metabolism, and Disease
- Probiotics and Fermented Foods
- Receptor Mechanisms and Signaling
- Agriculture and Biological Studies
- Culinary Culture and Tourism
- Nutrition, Genetics, and Disease
- Biochemical effects in animals
- Pancreatic function and diabetes
- Neurological Disease Mechanisms and Treatments
- Meat and Animal Product Quality
- Cholesterol and Lipid Metabolism
- Genetics and Physical Performance
- Sensory Analysis and Statistical Methods
- RNA and protein synthesis mechanisms
- Neurological Disorders and Treatments
Pavlov Institute of Physiology of the Russian Academy of Sciences
2011-2024
Russian Academy of Sciences
2010-2014
ABSTRACT Sweet taste is a powerful factor influencing food acceptance. There considerable variation in sweet perception and preferences within among species. Although learning homeostatic mechanisms contribute to this taste, much of it genetically determined. Recent studies have shown that the T1R genes contributes within‐ between‐species differences taste. In addition, our ongoing using mouse model demonstrate significant portion sweetener depends on are not involved peripheral processing....
The G-protein-coupled sweet taste receptor dimer T1R2/T1R3 is expressed in bud cells the oral cavity. In recent years, its involvement membrane glucose sensing was discovered endocrine regulating homeostasis. We investigated importance of extraorally T1R3 protein age-dependent control blood homeostasis vivo, using nonfasted mice with a targeted mutation Tas1r3 gene that encodes protein. Glucose and insulin tolerance tests, as well behavioral tests measuring responses to sucrose solutions,...
A commercial strain of Hafnia alvei (H. alvei) 4597 bacteria was shown to reduce food intake and promote weight loss, effects possibly induced by the bacterial protein ClpB, an antigen-mimetic anorexigenic α-melanocyte-stimulating hormone. decrease in basal plasma glucose levels also observed overweight fasted humans mice receiving H. alvei. However, it is not known whether influences sweet taste preference its extract or ClpB are sufficient increase tolerance; these objectives tested...
In mammals, inter- and intraspecies differences in consumption of sweeteners largely depend on allelic variation the Tas1r3 gene (locus Sac) encoding T1R3 protein, a sweet taste receptor subunit. To assess influence polymorphisms feeding behavior metabolism, we examined phenotype F1 male hybrids obtained from crosses between following inbred mouse strains: females 129SvPasCrl (129S2) bearing recessive allele males either C57BL/6J (B6), carrying dominant allele, or Tas1r3-gene knockout strain...
The membrane T1R taste receptor family interacts with sweet substances – carbohydrates, artificial sweeteners and some amino acids. An important result of research in the 21st century was discovery abundant expression these receptors outside oral cavity, mainly cells actively involved metabolic processes: enteroendocrine intestine, pancreatic β-cells, adipose bone tissue, etc. This review integrates analyzes current data on role extraoral regulation metabolism, cell growth differentiation,...
Abstract—Sweetness is the strongest gustatory modality, which shapes eating behavior and influences homeostasis. The review summarizes data on perception encoding of taste signals at level receptors brain centers during consumption sweet substances. We focus molecular cellular mechanisms identification determination food caloric content, including role membrane receptor proteins T1R2/T1R3 signal transduction enzyme cascades, as well a metabolic mechanism for estimating concentration glucose...
Taste receptors type 1, T1R, encoded by Tas1 genes play a key role in sweet and amino acid taste perception vertebrates. Significant differences food preferences, described different groups of animals, could be associated with interruption expression some encoding these proteins. Numerous polymorphisms were found mammals, including humans mice. These entail an increase the preference consumption substances affect receptor sensitivity. This makes study this system highly relevant light...
Введение. Ишемический инсульт головного мозга является одной из главных причин преждевременных смертей во всем мире, вызванные им когнитивные и функциональные нарушения ведут к инвалидизации. Для клинического использования в настоящее время одобрено лишь одно средство - рекомбинантный активатор плазминогена, который обеспечивает восстановление (реканализацию) мозгового кровотока. Средства эффективной нейропротекции, обеспечивающие непосредственную защиту нейронов от ишемии (предотвращение...