A5064276372- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Helminth infection and control
- IL-33, ST2, and ILC Pathways
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Trace Elements in Health
- Non-Invasive Vital Sign Monitoring
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Cardiovascular and exercise physiology
- Drug-Induced Hepatotoxicity and Protection
- Plant Toxicity and Pharmacological Properties
- Phytochemistry and Bioactivity Studies
- Immune Cell Function and Interaction
- Heart Rate Variability and Autonomic Control
- Research on Leishmaniasis Studies
- Zoonotic diseases and public health
Université de Yaoundé I
2018-2024
University of Pennsylvania
2023-2024
Université de Strasbourg
2022
Centre for Schistosomiasis & Parasitology
2018-2022
University of Maroua
2021
Université de Yaoundé II
2021
Background One of the considerable challenges schistosomiasis chemotherapy is inefficacy praziquantel (PZQ) at initial phase infection. Immature schistosomes are not susceptible to PZQ curative dose. Here, we investigated efficacy different regimens administered during stage Schistosoma mansoni infection in mice. Methodology/Principal findings Two months-old mice were individually infected with 80 S . cercariae and divided into one infected-untreated control group (IC) four PZQ-treated...
The roots of Ozoroa pulcherrima Schweinf are used in traditional medicine to treat intestinal helminthiasis. aim this study was assess the effect methanolic extract (OPME) on liver injury induced by Schistosoma mansoni mice. A preliminary phytochemical OPME conducted. given daily and orally S. mansoni-infected mice at 100, 200 or 400 mg/kg for 28 days, starting from 36th day post-infection. Praziquantel as reference drug. Non-infected infected-untreated served controls. Worm burden egg...
The macerate of Sida pilosa aerial parts is used empirically for the treatment intestinal helminthiasis. Previous studies have shown that aqueous extract (SpAE) has schistosomicidal, antioxidant, anti-inflammatory and anti-fibrotic activities in Schistosoma mansoni infection. This study was designed to evaluate effect SpAE on granulomatous inflammation induced by S. liver intestine mice histomorphometry; as well gastrointestinal motility. To histomorphometry motility, administered at 200...
Despite the global efforts, schistosomiasis remains a public health problem in several tropical and subtropical countries. One of major challenges fight against is interruption parasite life cycle. Here, we evaluated anticercarial, cytotoxicity, phytochemical profiles Sida acuta (HESa) rhombifolia (HESr) hydroethanolic extracts (Malvaceae). Schistosoma mansoni cercaria was collected from fifteen Biomphalaria pfeifferi-infected snails. Twenty-five cercariae were incubated duplicate with...
Background Undernutrition and schistosomiasis are public health problems often occur in low middle-income countries. Protein undernutrition can alter the host-parasite environment system aggravate course of schistosomiasis. This study aimed to assess impact a low-protein diet on efficacy praziquantel. Methodology/Principal findings Thirty-day-old mice were fed with diet, 40 days later, they individually infected fifty Schistosoma mansoni cercariae. A 28-day-treatment praziquantel at 100...
Aims: Continuous attempts are being made to develop new and more effective drugs for the treatment of schistosomiasis. Ozoroa pulcherrima Schweinf. is a medicinal plant used in Africa dysmenorrhea, lower abdominal pain, dystocia intestinal helminthiasis. This study provides findings on cercaricidal schistosomicidal activity extracts fractions vitro assays.
 Methodology: The aqueous methanolic from root parts (62.5 – 2000 µg/mL), as well methanol derived (n-hexane ethyl acetate: 31.25...
The incidence of schistosomiasis-induced male reproductive dysfunction and infertility is probably underestimated compared to female genital schistosomiasis. This study aimed investigate the impact Schistosoma haematobium or S. mansoni infection on function men age in Tibati Wouldé, two endemic schistosomiasis areas Adamawa region Cameroon.A total 89 (range 14-56 years) from localities were enrolled study, with 51 38 Wouldé. Each participant was submitted a questionnaire document data...
Abstract In Cameroon, there is a national programme engaged in the control of schistosomiasis and soil-transmitted helminthiasis. certain locations, transitioning from morbidity towards local interruption parasite transmission. The volcanic crater lake villages Barombi Mbo Kotto are well-known transmission foci excellent context-specific locations to assess appropriate disease interventions. Most recently they have served as exemplars expanded access deworming medications increased...
Abstract The lung microenvironment is a critical target organ for trapping and killing migratory larvae of the murine hookworm Nippostrongylus brasiliensis during memory type 2 immunity. However, relative contribution(s) group innate lymphoid (ILC2s) vs. T-helper (TH2) populations in host protection subsequent tissue repair are currently unknown. Data show that mice lacking locus control region 1 (LCR1-/-) have selective defect ILC2s resulting impaired larval killing, pulmonary hemorrhage,...
Background. Heart rate variability (HRV) analysis is a useful method for assessing the heart’s ability to adapt endogenous and exogenous loads. Data from African population on HRV are scarce even more so in sports populations. This study aimed compare cardiac autonomic modulation response Cameroonian athletes sedentary. Methodology. We conducted prospective analytical teams city of Yaoundé, Cameroon. The participants our were divided three groups; people who practiced little or no sporting...
Skin employs interdependent cellular networks to facilitate barrier integrity and host immunity through ill-defined mechanisms. This study demonstrates that manipulation of itch-sensing neurons bearing the Mas-related G protein-coupled receptor A3 (MrgprA3) drives IL-17+ γδ T cell expansion, epidermal thickening, resistance human pathogen Schistosoma mansoni mechanisms require myeloid antigen presenting cells (APC). Activated MrgprA3 instruct APCs downregulate interleukin 33 (IL-33)...
Abstract Background: The incidence of schistosomiasis‐induced male reproductive dysfunction and infertility is probably underestimated compared to female genital schistosomiasis. This study aimed investigate the impact S. haematobium or mansoni infection on function adult men in Tibati Wouldé, two schistosomiasis endemic areas Adamawa region Cameroon. Methods: A total 89 age (range: 14 – 56 years) from localities were enrolled study, with 51 38 Wouldé. Each participant was submitted a...
Aims: Treatment against schistosomiasis relies on praziquantel. Its treatment failure and the possible development of resistant schistosomes strains have been reported in literature. Clerodendrum umbellatum leaves are used Africa for intestinal helminthiasis. The aim this study was to evaluate vitro activity C. aqueous extract derived fractions Schistosoma mansoni adult worms.
 Methodology: Five male five female worms were incubated each well 48 h a GMEM culture medium with (125 4000...
Schistosomiasis control remains a public health concern, and there is need to evaluate new strategies for targeting larval adult stages of the parasite. As Pedilanthus tithymaloides empirically used treat schistosomiasis, it becomes essential know its effective action scientifically. This study assessed cercaricidal schistosomicidal activity P. stem barks raffia wine extract (RwPt) hydroethanolic (HePt). Different concentrations these extracts were tested against cercariae (31.25-1000 μg/mL)...
Abstract Background Undernutrition and schistosomiasis are public health problems often occur in low middle-income countries. Protein undernutrition can alter the host-parasite environment system aggravate course of schistosomiasis. This study aimed to assess impact a protein-deficient diet on efficacy praziquantel. Methodology/principal findings Thirty-day-old mice were fed with diet, 40 days later, they individually infected fifty Schistosoma mansoni cercariae. A 28-day-treatment...
Abstract Background: The incidence of schistosomiasis‐induced male reproductive dysfunction and infertility is probably underestimated comparing to female genital schistosomiasis. This study aimed investigate the impact S. haematobium or mansoni infection on function adult men in Tibati Wouldé, two schistosomiasis endemic areas Adamawa region Cameroon. Methods: A total 89 age (range: 14 – 56 years) from localities were enrolled with 51 38 Wouldé. Each participant was submitted a...