A5037685556- Statistical Methods and Inference
- Gene expression and cancer classification
- Statistical Methods and Bayesian Inference
- Statistical Methods in Clinical Trials
- Bayesian Methods and Mixture Models
- Head and Neck Cancer Studies
- Single-cell and spatial transcriptomics
- Advanced MRI Techniques and Applications
- Advanced Causal Inference Techniques
- Bioinformatics and Genomic Networks
- Optimal Experimental Design Methods
- Genetic Associations and Epidemiology
- Viral gastroenteritis research and epidemiology
- Statistical Distribution Estimation and Applications
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Voice and Speech Disorders
- Reliability and Agreement in Measurement
- Bladder and Urothelial Cancer Treatments
- Genomic variations and chromosomal abnormalities
- Eosinophilic Esophagitis
- Probability and Risk Models
- Molecular Biology Techniques and Applications
- Acute Kidney Injury Research
- Tracheal and airway disorders
Jilin University
2018-2025
Florida State University
2020-2025
Universidad del Noreste
2025
Zigong First People's Hospital
2025
Woodward (United States)
2021-2024
Rongcheng City People's Hospital
2022
Xiangtan University
2021
Gunma University
2021
Shanghai Maritime University
2021
Shaanxi Normal University
2021
Abstract Motivation Millions of protein sequences have been generated by numerous genome and transcriptome sequencing projects. However, experimentally determining the function proteins is still a time consuming, low-throughput, expensive process, leading to large sequence-function gap. Therefore, it important develop computational methods accurately predict fill Even though many developed use as input function, much fewer leverage structures in prediction because there was lack accurate for...
Staphyococcus aureus frequently causes recurrent skin and soft-tissue infection (SSTI). In the pediatric population, elevated serum antibody targeting S. α-toxin is correlated with a reduced incidence of SSTI. Using novel model SSTI, we demonstrated that expression during primary increases severity disease. Antagonism by either dominant-negative toxin mutant or small molecule inhibitor receptor ADAM10 reduces reinfection abscess severity. Early neutralization activity SSTI therefore offers...
Abstract Motivation Next generation sequencing technologies have enabled the study of human microbiome through direct microbial DNA, resulting in an enormous amount data. One unique characteristic data is phylogenetic tree that relates all bacterial species. Closely related species a tendency to exhibit similar relationship with environment or disease. Thus, incorporating information can potentially improve detection power for microbiome-wide association studies, where hundreds thousands...
We study the transformed hazards model with time-dependent covariates observed intermittently for censored outcome. Existing work assumes availability of whole trajectory covariates, which is unrealistic. propose combining kernel-weighted log-likelihood and sieve maximum estimation to conduct statistical inference. The method robust easy implement. establish asymptotic properties proposed estimator contribute a rigorous theoretical framework general M-estimators. Numerical studies...
Abstract Purpose: To establish a cohort of high-risk women undergoing intensive surveillance for breast cancer. Experimental Design: We performed dynamic contrast-enhanced MRI every 6 months in conjunction with annual mammography (MG). Eligible participants had cumulative lifetime cancer risk ≥20% and/or tested positive pathogenic mutation known susceptibility gene. Results: Between 2004 and 2016, we prospectively enrolled 295 women, including 157 carriers (75 BRCA1, 61 BRCA2); participants'...
BackgroundWe utilized data from the Health Effects of Arsenic Longitudinal Study (HEALS) in Araihazar, Bangladesh, to evaluate association steamed rice consumption with urinary total arsenic concentration and arsenical skin lesions overall study cohort (N=18,470) a subset available metabolite (N=4,517). MethodsGeneral linear models standardized beta coefficients were used estimate associations between metabolites. Logistic regression prevalence odds ratios (ORs) their 95% confidence...
Highly loaded rotor systems, such as those in aero-engines, exhibit complex vibration behaviors due to the discontinuities bolted structure, which generate friction at connection interfaces. This leads nonlinear dynamics for system. A dynamic model of system is established using finite element theoretical Methods, incorporating connections around entire circumference. The procedure assessing stick-slip states bolts different positions during motion provided. study examines phenomenon...
We study the multiplicative hazards model with intermittently observed longitudinal covariates and time-varying coefficients. For such models, existing ad hoc approach, as last value carried forward, is biased. propose a kernel weighting approach to get an unbiased estimation of nonparametric coefficient function establish asymptotic normality for any fixed time point. Furthermore, we construct simultaneous confidence band examine overall magnitude variation. Simulation studies support our...
<sec><title>BACKGROUND</title>To evaluate currently recommended dosage using the population pharmacokinetics (PK) of bedaquiline (BDQ), clofazimine, cycloserine, linezolid (LZD) and moxifloxacin (MFX) in patients with multidrug-resistant TB (MDR-TB) type II diabetes mellitus (DM).</sec><sec><title>METHODS</title>A prospective multi-centre PK study was conducted China between 2016 2019. Population models were developed nonlinear mixed-effect analyses based on blood samples collected by rich...
Abstract Data obtained from high throughput experiments often exhibit complex dependencies among features. These arise various sources, including genetic correlation, batch effects, technical replicates, and shared biological pathways. Ignoring these can lead to inflated false discovery rate (FDR), reduced statistical power, biased interpretations. Properly accounting for is crucial accurate detection of signals. We propose a new method called Analysis Correlated Expressions (ACE) compare...
Objectives: To assess the prevalence of psychological symptoms (depression, anxiety) among Chinese medical students and to find possible relationships between social relationships. Methods: A sample 10,140 was investigated with a structured questionnaire, that included Beck Depression Inventory, Anxiety Social Support Rating Scale, Family APGAR Index (adaptability, partnership, growth, affection, resolve). Results: The present study revealed 16.8% suffered from depressive 14.1% anxiety...
COVID-19 has heterogeneous manifestations, though one of the most common symptoms is a sudden loss smell (anosmia or hyposmia). We investigated whether olfactory reliable predictor COVID-19. This preregistered, cross-sectional study used crowdsourced questionnaire in 23 languages to assess individuals self-reporting recent respiratory illness. quantified changes chemosensory abilities during course illness using 0-100 visual analog scales (VAS) for participants reporting positive (C19+;...
Millions of protein sequences have been generated by numerous genome and transcriptome sequencing projects. However, experimentally determining the function proteins is still a time consuming, low-throughput, expensive process, leading to large sequence-function gap. Therefore, it important develop computational methods accurately predict fill Even though many developed use as input function, much fewer leverage structures in prediction because there was lack accurate for most until...
In single hypothesis testing, power is a nondecreasing function of Type I error rate; hence it desirable to test at the nominal level exactly achieve optimal power. The puzzle arises from fact that for multiple testing under false discovery rate paradigm, such monotonic relationship may not hold. particular, exact control lead less powerful procedure if statistic fails fulfil monotone likelihood ratio condition. this article, we identify different scenarios wherein condition and give caveats...
Regression analysis of censored failure observations via the proportional hazards model permits time-varying covariates which are observed at death times. In practice, such longitudinal typically sparse and only measured infrequent irregularly spaced follow-up Full likelihood analyses joint models for survival data impose stringent modelling assumptions difficult to verify in practice complicated both inferentially computationally. this article, a simple kernel weighted score function is...
Journal Article Changepoint estimation: another look at multiple testing problems Get access Hongyuan Cao, Cao Department of Statistics, University Missouri-Columbia, Columbia, Missouri 65211, U.S.A. caohong@missouri.edu Search for other works by this author on: Oxford Academic Google Scholar Wei Biao Wu Chicago, Illinois 60637, U.S.A., wbwu@uchicago.edu Biometrika, Volume 102, Issue 4, December 2015, Pages 974–980, https://doi.org/10.1093/biomet/asv031 Published: 24 July 2015 history...
BACKGROUND Although black patients experience worse outcomes after treatment for squamous cell carcinoma of the head and neck (HNSCC), these conclusions were based on populations in which blacks comprised a minority patients. The objective current study was to determine impact race with HNSCC who received radiotherapy at an institution majority METHODS In this retrospective cohort study, authors reviewed 366 236 white had nonmetastatic they between 1990 2012. primary outcome measures...
In clinical studies, it is often of interest to see the diagnostic agreement among clinicians on certain symptoms. Previous work has focused between two under different conditions or multiple one condition. Few have discussed study with a design where examine same group patients conditions. this paper, we use intraclass kappa statistic for assessing nominal scale such design. We derive an explicit variance formula difference correlated statistics and conduct hypothesis testing equality...
Background: Although the pentavalent rotavirus vaccine was highly efficacious against diarrhea in clinical trials, effectiveness of under field conditions developing world is unclear. In October 2006, Nicaragua became first nation to implement universal infant immunization with vaccine. To assess effect program, we examined incidence episodes between 2003 and 2009 among children state León, Nicaragua. Methods: We extracted data on from health ministry records. used scaled Poisson regression...