A5069678379- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- BRCA gene mutations in cancer
- Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Genetic factors in colorectal cancer
- CRISPR and Genetic Engineering
- Breast Cancer Treatment Studies
- Advanced MRI Techniques and Applications
- RNA modifications and cancer
- MRI in cancer diagnosis
- AI in cancer detection
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- HER2/EGFR in Cancer Research
- RNA and protein synthesis mechanisms
- Genetic Associations and Epidemiology
- Circular RNAs in diseases
- Advanced biosensing and bioanalysis techniques
- Nutrition, Genetics, and Disease
- Gene expression and cancer classification
- Immunotherapy and Immune Responses
University of Chicago
2016-2025
Cancer Genetics (United States)
2012-2024
Chicago Department of Public Health
2024
Walsh University
2018
Lagos State University
2016-2017
Lagos State University Teaching Hospital
2016-2017
University of Ibadan
2016-2017
Center for Global Health
2017
Novartis (United States)
2016-2017
Walter Reed National Military Medical Center
2017
African Americans have the highest breast cancer mortality rate. Although racial difference in distribution of intrinsic subtypes is known, it unclear if there are other inherent genomic differences that contribute to survival disparities.To investigate molecular features and estimate heritability subtypes.Among a convenience cohort patients with invasive cancer, tumor matched normal tissue sample data (as September 18, 2015) were obtained from The Cancer Genome Atlas.Breast cancer–free...
Among Nigerian women, breast cancer is diagnosed at later stages, more frequently triple-negative disease, and far fatal than in Europe or the United States. We evaluated contribution of an inherited predisposition to this population.
Abstract Racial/ethnic disparities in breast cancer mortality continue to widen but genomic studies rarely interrogate diverse populations. Through genome, exome, and RNA sequencing, we examined the molecular features of cancers using 194 patients from Nigeria 1037 The Cancer Genome Atlas (TCGA). Relative Black White cohorts TCGA, Nigerian HR + /HER2 − tumors are characterized by increased homologous recombination deficiency signature, pervasive TP53 mutations, greater structural...
Importance Among patients with breast cancer, inconsistent findings have been published on racial disparities in achieving pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT). Objective To investigate whether exist pCR and what factors contribute to them. Design, Setting, Participants Within the ongoing Chicago Multiethnic Epidemiologic Breast Cancer Cohort (ChiMEC), which consists of a prospectively ascertained cohort 690 stage I III cancer receiving NACT were...
There is an urgent need for novel noninvasive prognostic biomarkers monitoring the recurrence of breast cancer. The purpose this study to identify circulating microRNAs that can predict cancer recurrence. We conducted a microRNA profiling experiment in serum samples from 48 patients using Exiqon miRCURY RT-PCR panels. Significantly differentiated miRNAs discovery were further validated independent set sera 20 with recurrences and 22 without recurrences. identified seven differentially...
Imaging techniques can provide information about the tumor non-invasively and have been shown to underlying genetic makeup. Correlating image-based phenotypes (radiomics) with genomic analyses is an emerging area of research commonly referred as "radiogenomics" or "imaging-genomics". The purpose this study was assess potential for using automated, quantitative radiomics platform on magnetic resonance (MR) breast imaging inferring activity clinically relevant gene pathways derived from RNA...
Sub-Saharan Africa (SSA) has a high proportion of premenopausal hormone receptor negative breast cancer. Previous studies reported strikingly prevalence germline mutations in BRCA1 and BRCA2 among Nigerian patients with It is unknown if this exists other SSA countries.Breast cancer cases, unselected for age at diagnosis family history, were recruited from tertiary hospitals Kampala, Uganda Yaoundé, Cameroon. Controls women without the same age-matched to cases. A multigene sequencing panel...
Abstract Background Endocrine-resistant HR+/HER2- breast cancer (BC) and triple-negative BC (TNBC) are of interest for molecularly informed treatment due to their aggressive natures limited profiles. Patients African Ancestry (AA) experience higher rates TNBC mortality than European (EA) patients, despite lower overall incidence. Here, we compare the molecular landscapes AA EA patients with in a real-world cohort promote equity precision oncology by illuminating heterogeneity potentially...
Abstract BACKGROUND Accurate evaluation of unclassified sequence variants in cancer predisposition genes is essential for clinical management and depends on a multifactorial analysis clinical, genetic, pathologic, bioinformatic variables assays transcript length abundance. The integrity assay data turn relies appropriate design, interpretation, reporting. METHODS We conducted multicenter investigation to compare mRNA splicing protocols used by members the ENIGMA (Evidence-Based Network...
Abstract Purpose: To establish a cohort of high-risk women undergoing intensive surveillance for breast cancer. Experimental Design: We performed dynamic contrast-enhanced MRI every 6 months in conjunction with annual mammography (MG). Eligible participants had cumulative lifetime cancer risk ≥20% and/or tested positive pathogenic mutation known susceptibility gene. Results: Between 2004 and 2016, we prospectively enrolled 295 women, including 157 carriers (75 BRCA1, 61 BRCA2); participants'...
<h3>Background</h3> <i>BRCA1</i> and <i>BRCA2</i> are the two principal tumour suppressor genes associated with inherited high risk of breast ovarian cancer. Genetic testing <i>BRCA1</i>/2 will often reveal one or more sequence variants uncertain clinical significance, some which may affect normal splicing patterns thereby disrupt gene function. mRNA analyses therefore among tests used to interpret significance genetic variants. However, these could be confounded by appearance naturally...
Abstract Black women across the African diaspora experience more aggressive breast cancer with higher mortality rates than white of European ancestry. Although inter-ethnic germline variation is known, differential somatic evolution has not been investigated in detail. Analysis deep whole genomes 97 cancers, RNA-seq a subset, from Nigeria comparison The Cancer Genome Atlas (n = 76) reveal rate genomic instability and increased intra-tumoral heterogeneity as well unique subtype defined by...
Importance Most breast cancers in Africa are diagnosed at advanced stages. Improved risk prediction tools to optimize screening and earlier diagnosis urgently needed. Objective To build a comprehensive cancer estimation model by integrating polygenic score (PRS), pathogenic variants (PVs) high- or moderate-penetrance genes, questionnaire-based calculator. Design, Setting, Participants This multicenter case-control study initially enrolled women Nigeria 1998 expanded Cameroon Uganda 2011;...
Abstract Background: Breast cancer (BC) is a heterogenous disease, and the rising global epidemic of premenopausal BC remains poorly understood. Mutational landscape evolutionary dynamics from diverse geography populations are largely unknown, preventing acceleration progress towards precision prevention. Methods: To examine etiology heterogeneity in indigenous Africans, 43 multi-region tumor samples blood 18 Nigerian women with (mean age 53 +/-12.7) were analyzed. Whole Genome Sequencing...
African-ancestry (AA) participants are underrepresented in genetics research. Here, we conducted a transcriptome-wide association study (TWAS) AA female to identify putative breast cancer susceptibility genes. We built genetic models predict levels of gene expression, exon junction, and 3' UTR alternative polyadenylation using genomic transcriptomic data generated normal tissues from 150 then used these perform analyses 18,034 cases 22,104 controls. At Bonferroni-corrected P < 0.05,...
To externally evaluate a mammography-based deep learning (DL) model (Mirai) in high-risk racially diverse population and compare its performance with other mammographic measures. A total of 6435 screening mammograms 2096 female patients (median age, 56.4 years ± 11.2 [SD]) enrolled hospital-based case-control study from 2006 to 2020 were retrospectively evaluated. Pathologically confirmed breast cancer was the primary outcome. Mirai scores predictors. Breast density Imaging Reporting Data...
Somatic mutation signatures may represent footprints of genetic and environmental exposures that cause different cancer. Few studies have comprehensively examined their association with germline variants, none in an indigenous African population. SomaticSignatures was employed to extract based on whole‐genome or whole‐exome sequencing data from female patients breast cancer (TCGA, training set, n = 1,011; Nigerian samples, validation 170), estimate contributions each sample. Association...
Importance There has been little consideration of genomic risk recurrence by breast cancer subtype despite evidence racial disparities in outcomes. Objective To evaluate associations between clinical trial end points, namely pathologic complete response (pCR) and distant recurrence–free survival (DRFS), race examine whether gene expression signatures are associated with outcomes race. Design, Setting, Participants This retrospective cohort study used data from the Investigation Serial...
Black women experience the highest breast cancer mortality rate compared with of other racial/ethnic groups. To gain a deeper understanding heterogeneity across diverse populations, we examined VEGF-hypoxia gene expression signature in tumors from ancestry.
Genetic variants in hormone receptor genes may be crucial predisposing factors for breast cancer, and microsatellites the estrogen (ESR1, ESR2) androgen (AR) have been suggested to play a role. We studied 258 African-American (AA) women with cancer 259 hospital-based controls, as well 349 Nigerian (NG) female patients 296 community controls. Three microsatellites, ESR1_TA, ESR2_CA AR_CAG, ESR1, ESR2 AR genes, respectively, were genotyped. Their repeat lengths then analyzed continuous...
Innate immune defense mechanisms play a pivotal role in antitumor responses. Recent evidence suggests that antiviral innate immunity is regulated not only by exogenous non-self-RNA but also host-derived pseudogene RNAs. A growing body of indicates biological for pseudogenes as gene expression regulators or modulators. Here, we report an important BRCA1P1, the BRCA1 tumor-suppressor gene, regulating breast cancer cells. BRCA1P1 expresses long-noncoding RNA (lncRNA) cells through divergent...
<div>AbstractPurpose:<p>Black women experience the highest breast cancer mortality rate compared with of other racial/ethnic groups. To gain a deeper understanding heterogeneity across diverse populations, we examined VEGF-hypoxia gene expression signature in tumors from ancestry.</p>Experimental Design:<p>We developed NanoString nCounter panel and applied it to Nigeria (<i>n</i> = 182) University Chicago (Chicago, IL; <i>n</i> 161). We also...
<div>AbstractPurpose:<p>Black women experience the highest breast cancer mortality rate compared with of other racial/ethnic groups. To gain a deeper understanding heterogeneity across diverse populations, we examined VEGF-hypoxia gene expression signature in tumors from ancestry.</p>Experimental Design:<p>We developed NanoString nCounter panel and applied it to Nigeria (<i>n</i> = 182) University Chicago (Chicago, IL; <i>n</i> 161). We also...