A5090122994- Sarcoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- AI in cancer detection
- Cancer Research and Treatments
- Virus-based gene therapy research
- Hedgehog Signaling Pathway Studies
- Effects of Radiation Exposure
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Asthma and respiratory diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Colorectal Cancer Surgical Treatments
- Renal and related cancers
- Biological Research and Disease Studies
University of North Carolina at Chapel Hill
2024-2025
UNC Lineberger Comprehensive Cancer Center
2024-2025
Tempus Labs (United States)
2023
Estrogens regulate eosinophilia in asthma and other inflammatory diseases. Further, peripheral tumor-associated tissue (TATE) predicts a better response to immune checkpoint blockade (ICB) breast cancer. However, how if estrogens affect eosinophil biology tumors this influences ICB efficacy has not been determined. Here, we report that decrease the number of eosinophils TATE, contributes increased tumor growth validated murine models cancer melanoma. Moreover, estrogen signaling healthy...
Abstract Despite advances in diagnostic and therapeutic strategies, the prognosis of lung squamous cell carcinoma (LUSC) patients remains poor, potential microbiome-based prognostic biomarkers targets largely unexplored. LUSC patient data from The Cancer Genome Atlas (TCGA), including microbial genus level abundance RNA sequencing (RNA-Seq) data, were used as a training dataset. Two other independent datasets GSE19188 GSE157009 serve validation datasets. A risk score (RS) model was...
While numerous methods have been developed for analyzing scRNA-seq data, benchmarking various remains challenging. There is a lack of ground truth datasets evaluating novel gene selection and/or clustering methods. We propose the use crafted experiments, new approach based upon perturbing signals in real dataset comparing analysis demonstrate effectiveness experiments univariate distribution-oriented suite feature methods, called GOF. show GOF selects features that robustly identify and...
Black women experience the highest breast cancer mortality rate compared with of other racial/ethnic groups. To gain a deeper understanding heterogeneity across diverse populations, we examined VEGF-hypoxia gene expression signature in tumors from ancestry.
572 Background: Endocrine therapy (ET) reduces mortality in hormonally driven breast cancer (BC). The impacts of ET on the estrogen receptor are well known; however, there is limited data impact host's immune system. This project aims to elucidate potential immunomodulatory effects ET-induced deprivation HR+/HER2 negative early-stage patients (pts) as baseline differences between BC pts and healthy controls (HC). Methods: Pts with Stage I-III HR+/HER2- initiating after completion local...
<div>AbstractPurpose:<p>Black women experience the highest breast cancer mortality rate compared with of other racial/ethnic groups. To gain a deeper understanding heterogeneity across diverse populations, we examined VEGF-hypoxia gene expression signature in tumors from ancestry.</p>Experimental Design:<p>We developed NanoString nCounter panel and applied it to Nigeria (<i>n</i> = 182) University Chicago (Chicago, IL; <i>n</i> 161). We also...
<div>AbstractPurpose:<p>Black women experience the highest breast cancer mortality rate compared with of other racial/ethnic groups. To gain a deeper understanding heterogeneity across diverse populations, we examined VEGF-hypoxia gene expression signature in tumors from ancestry.</p>Experimental Design:<p>We developed NanoString nCounter panel and applied it to Nigeria (<i>n</i> = 182) University Chicago (Chicago, IL; <i>n</i> 161). We also...
<p>Supplementary Fig. S1. Correlation with T-Cell Immune Module Scores.</p>
<p>Supplementary Fig. S4. No Correlation with Immune Cell Infiltration in the Basal-like Subtype Tumors.</p>
<p>Supplementary Fig. S3. An Association with MKI67, ESR1, or ERBB2 Expression.</p>
<p>Supplementary Fig. S1. Correlation with T-Cell Immune Module Scores.</p>
<p>Supplementary Fig. S2. Correlation with Other Immune Modules.</p>
<p>Supplementary Fig. S4. No Correlation with Immune Cell Infiltration in the Basal-like Subtype Tumors.</p>
<p>Supplementary Fig. S2. Correlation with Other Immune Modules.</p>
<p>Supplementary Fig. S3. An Association with MKI67, ESR1, or ERBB2 Expression.</p>
Breast cancer (BC) is a highly common form of that occurs in many parts the world. However, early -stage BC curable. Many patients with have poor prognostic outcomes owing to ineffective diagnostic and therapeutic tools. The ubiquitination system associated proteins were found influencing outcome individuals cancer. Therefore, developing biomarker genes forecast patient feasible strategy.
Ten eleven translocation (TET) proteins are tumor suppressors that through their catalytic activity oxidize 5-methylcytosine to 5-hydroxymethylcytosine, promote DNA demethylation and regulate gene expression. Notably, TET2 is one of the most frequently mutated genes in hematological malignancies, including T cell lymphomas. However, murine models with deletion do not exhibit expansion, presumably due redundancy other members TET family proteins. In order gain insight on mediated molecular...
Approximately half of patients with cancer receive radiotherapy and, as survivorship increases, the low rate radiation-associated sarcomas is rising. Pharmacologic inhibition p53 has been proposed an approach to ameliorate acute injury normal tissues from genotoxic therapies, but how this might impact risk therapy-induced and tissue injuries remains unclear. We utilized mice that express a doxycycline (dox)-inducible short hairpin RNA reduce Trp53 expression temporarily during irradiation....
<p>Radiation-induced chronic injuries increase the risk of sarcomagenesis. <b>A,</b> The final injury scores control and p53KD mice that received 30 or 40 Gy are plotted. did not develop a radiation-induced sarcoma (blue) compared with (red). <i>P</i> value is from <i>t</i> test. <b>B,</b> Kaplan–Meier curves show sarcoma-free survival irradiated to hind limb. Mice equal less than 3 greater 3. cox proportional hazards model.</p>
<p>Supplementary figure S7 shows gene expression analysis of radiation-induced sarcomas compared to normal muscles</p>
<p>Radiation-induced chronic injuries increase the risk of sarcomagenesis. <b>A,</b> The final injury scores control and p53KD mice that received 30 or 40 Gy are plotted. did not develop a radiation-induced sarcoma (blue) compared with (red). <i>P</i> value is from <i>t</i> test. <b>B,</b> Kaplan–Meier curves show sarcoma-free survival irradiated to hind limb. Mice equal less than 3 greater 3. cox proportional hazards model.</p>