Evolutionary adaptations associated with the formation of a folded cortex in many mammalian brains are thought to be critical specialization higher cognitive function. The dramatic surface expansion and highly convoluted folding during early development is theme variations that suggest need for comparative study cortical gyrification. Here, we use combination physical experiments using gels, computational morphogenesis, geometric morphometrics across different species. Starting magnetic...

This study investigated the sources of stress, corresponding symptoms, and stress relief among nurses first Chinese anti-Ebola medical team during Sierra Leone aid mission.A purposive sampling method was used 10 were selected from that dispatched to Leone. Data collected via phone semi-structured interviews, then analyzed using Colaizzi's seven-step method.The data showed three major themes: (1) The causes mission mainly related unsafety, responsibility, unfamiliarity; (2) Physical,...

Purpose Suicide is a global concern, especially among young people. prediction models have the potential to make it easier identify patients who are at high risk of suicide, but they very little predictive power when there positive value for suicide mortality. Therefore, aim study uncover factors associated with by self-poisoning and further provide trustworthy nomogram predict poisoned patients. Methods This prospectively enrolled 237 were treated poisoning Fifth Medical Center PLA General...

Morpho butterflies are universally admired for their iridescent blue coloration, which is due to nanostructured wing scales. We performed a comparative study on the coloration of 16 species, investigating morphological, spectral and spatial scattering properties differently organized In numerous previous studies, bright has been fully attributed multi-layered ridges cover scales' upper laminae, but we found that lower laminae ground scales play an important additional role, by acting as...

Abstract Despite advances in diagnostic and therapeutic strategies, the prognosis of lung squamous cell carcinoma (LUSC) patients remains poor, potential microbiome-based prognostic biomarkers targets largely unexplored. LUSC patient data from The Cancer Genome Atlas (TCGA), including microbial genus level abundance RNA sequencing (RNA-Seq) data, were used as a training dataset. Two other independent datasets GSE19188 GSE157009 serve validation datasets. A risk score (RS) model was...

A mechanistic understanding of neurodevelopment requires us to follow the multiscale processes that connect molecular genetic macroscopic cerebral cortical formations and thence neurological function. Using magnetic resonance imaging brain ferret, a model organism for studying morphogenesis, we create in vitro physical gel models silico numerical simulations normal gyrification. observations genetically manipulated animal models, identify thickness expansion rate as primary drivers...

Although diagnostic methods, surgical techniques, and perioperative care have undergone significant advancement over the past decades, prognosis of primary hepatocellular carcinoma (HCC) remains discouraged because high postoperative recurrence rate cancer mortality. Radiofrequency ablation (RFA) combined with transcatheter arterial chemoembolization (TACE) is a recently developed means for treatment HCC. In this study, we analyzed efficacy RFA plus TACE in 487 cases HCC our institution. We...

Controlling intracellular osmolarity is essential to all cellular life. Cells that live in hypo-osmotic environments, such as freshwater, must constantly battle water influx avoid swelling until they burst. Many eukaryotic cells use contractile vacuoles collect excess from the cytosol and pump it out of cell. Although are many species, including important pathogens, mechanisms control their dynamics remain unclear. To identify basic principles governing vacuole function, we investigate here...

Abstract Dry eye disease (DED) has high personal and societal costs, but its pathology remains elusive due to intertwined biophysical biochemical processes at the ocular surface. Specifically, mucin deficiency is reported in a subset of DED patients, effects on interfacial properties remain unclear. Herein novel vitro mucin‐deficient mimetic surface (Mu‐DeMOS) with controllable amount membrane‐tethered molecules developed represent diseased surfaces. Contact angle goniometry surfaces reveals...

Patients with hepatocellular carcinoma (HCC) exhibit a high incidence of concomitant cirrhosis leukopenia and/or thrombocytopenia. In the present study, perioperative changes in white blood cell (WBC) and platelet (PLT) counts associated complications were investigated to assess safety transcatheter arterial chemoembolization (TACE) for HCC patients preprocedural or The records 1,461 who received TACE between January 2012 December 2013 retrospectively reviewed. during period WBC PLT...

Dry eye disease (DED) affects more than 100 million people worldwide, causing significant patient discomfort and imposing a multi-billion-dollar burden on global health care systems. In DED patients, the natural biolubrication process that facilitates pain-free blinking goes awry due to an imbalance of lipids, aqueous medium, mucins in tear film, resulting ocular surface damage. Identifying strategies reduce adhesion shear stresses between conjunctival cells lining inside eyelid during blink...

Coherent beam combination of ten fiber arrays using a stochastic parallel gradient descent (SPGD) algorithm is demonstrated. A high speed phase controller has been designed and manufactured based on the SPGD field programmable gate array (FPGA). The signal processing FPGA circuit 50 MHz its iteration rate more than 200 kHz. Experimental investigation coherent 10 laser beams successfully demonstrated, with imposing additional disturbances to mimic noises in power amplifiers. combining...

It would be very helpful to stratify patients and direct patient selection if risk factors for quality of life were identified in a particular population. Nonetheless, it is still challenging forecast the health-related among individuals with spinal metastases. The goal this study was patient's populations whom assessment should encouraged by developing validating nomogram predict advanced cancer spine metastases.This prospectively analyzed 208 metastases, collected their general...

Differentially encoding and frequency offset compensating for a 16-quadrature amplitude modulation (16-QAM) vector signal in 60-GHz millimeter-wave radio-over-fiber (RoF) systems are experimentally investigated. The fourfold phase ambiguity issue non-data-aided communication transmission system with conventional square 16-QAM constellations is successfully tackled based on the differentially scheme. Experimental results show that compensation carrier recovery simultaneously achieved by...

Purpose: To quantify the effect of silicone hydrogel crosslink density on adhesion at corneal epithelial cells/silicone contact lens interface. Methods: A custom-built rheometer, referred to as live cell monolayer was used measure adhesive strengths between monolayers and surfaces. The resulting stress relaxations senofilcon A–derived materials with varying crosslinking densities delefilcon were tested. Senofilcon A–like labeled L1, L2, L3, L4, L5 contained crosslinker concentrations 1.2,...

Percutaneous ethanol injection is an important localized treatment method for patients presenting with hepatocellular carcinoma (HCC). Among the advantages of percutaneous are its minimal invasiveness, simplicity, low cost and risk complications. However, increasing popularity has resulted in serious adverse effects attributed to individual variations. The present study describes case a patient who exhibited acquired amegakaryocytic thrombocytopenic purpura, caused by HCC. This complication...

We present a field-theoretic model to predict the equilibrium thermodynamic behavior of semiflexible diblock copolymers and random in presence solvent. find that both systems polymer–solvent contacts dramatically influence with decreasing copolymer segment length (i.e., molecular weight). When has unequal monomer composition, polymer solvent concentration have strong on phase transition spinodal magnitude critical wave modes. Diblock exhibit an expanded region lamellar diagram chain...

e15120 Background: Clinical trials suggest that combining therapy of transcatheter arterial chemoembolization (TACE) with sorafenib for the treatment patients advanced hepatocellular carcinoma (HCC) shows a superior safety and tolerability profile. The present study aimed to retrospectively analyze utility prognostic factors this combined in HCC patients. Methods: Patients HCC, treated by TACE subsequently, between February 2010 September 2012 our hospital, were analyzed. After 12 weeks,...

Objective To analyze whether occur pain during radiofrequency ablation (RFA) by preoperative monitoring of vital signs and recording the types amount (RF) needles, so as to enhance predictive nursing ability effects management. Methods We retrospectively analyzed relationship between signs, RF needles with intraoperative among 367 primary liver cancer patients from February October 2013. The Logistic regression model was used for statistical analysis. Results The influencing...