A5026285817- Inflammasome and immune disorders
- Immune Response and Inflammation
- Influenza Virus Research Studies
- interferon and immune responses
- Inflammatory mediators and NSAID effects
- Parvovirus B19 Infection Studies
- Immune cells in cancer
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Medicinal Plants and Bioactive Compounds
- Berberine and alkaloids research
- Autoimmune and Inflammatory Disorders Research
- Electrolyte and hormonal disorders
- Peroxisome Proliferator-Activated Receptors
- Cancer Immunotherapy and Biomarkers
- Systemic Lupus Erythematosus Research
- Rabies epidemiology and control
- Dermatological and COVID-19 studies
- Drug-Induced Hepatotoxicity and Protection
- Fungal Infections and Studies
- Nosocomial Infections in ICU
- Multiple Sclerosis Research Studies
- Ion Transport and Channel Regulation
- Hepatitis C virus research
- COVID-19 epidemiological studies
RMIT University
2025
Zunyi Medical University
2024
Third Affiliated Hospital of Sun Yat-sen University
2013-2022
Sun Yat-sen University
2013-2022
SAGE Publishing (United States)
2019
National Institute for Communicable Disease Control and Prevention
2015
302 Military Hospital of China
2015
In the post-COVID-19 era, dynamic spread of COVID-19 poses new challenges to epidemiological modelling, particularly due absence large-scale screening and growing complexity introduced by immune failure reinfections. This paper proposes an AEIHD (antibody-acquired, exposed, infected, hospitalised, deceased) model analyse predict transmission dynamics in era. removes susceptible compartment combines recovered vaccinated compartments into “antibody-acquired” compartment. It also introduces a...
Context: The fruit of Xanthium strumarium L. (Asteraceae) has been used for the treatment various inflammatory diseases.Objective: This study investigates protective effect caffeoylxanthiazonoside (CYXD) isolated from fruits X. on sepsis mice in vitro and vivo.Materials methods: Cecal ligation puncture (CLP) operation was to establish model, sham were also performed. CYXD administered by intraperitoneal injection (10, 20, 40 mg/kg/d), then survival rate measured 96 h. Additionally, induced...
Macrophages play an important role in inflammatory responses; however, miRNA-mediated repolarization of macrophages is essential for fulfilling this function. To clarify a series changes at the RNA level alveolar under normal and conditions, bronchial lavage liquid (BALF) was collected from healthy volunteers or patients with pneumonia. This approach, which differs that used previously, provides more accurate information about states different lung microenvironments. In study, density plots...
Severe hyperthyroidism is a life-threatening exacerbation of thyrotoxicosis, characterized by high fever and multiorgan failure. The most common medical treatments are administration antithyroid drugs radioactive iodine, thyroidectomy. In some patients, therapy limited due to serious adverse effects or failure control disease progression. extreme cases, such as thyroid storm, conventional alone does not yield effective rapid improvement before the development failure.This report describes...
Klebsiella pneumoniae (K. pneumoniae) used to affect mainly people with compromised immunity or weakened by other infections, but recent emergence of hypervirulent strains has increased infections even in healthy individuals. These include liver abscess, pneumonia, bacteremia, meningitis, necrotizing fasciitis, and endophthalmitis. Although metastatic infection K. (hvKP) is increasingly recognized, co-infection Cryptococcus neoformans (C. neoformans) meningitis immunocompetent hosts rare...
Abstract Secondary methicillin‐resistant Staphylococcus aureus (MRSA) infection is a cause of severe pneumonia with high mortality during influenza A virus (IAV) pandemics. Alveolar macrophages (AMs) mount cellular defenses against IAV and MRSA infection, which occurs via the nucleotide‐binding domain‐like receptor protein 3 (NLRP3) inflammasome. However, activity function NLRP3 inflammasome in secondary to remain unclear. To clarify this, we studied both vitro mouse model. The expression...
Background Human parvovirus B19 ( ) can cause acute hepatitis and is attributed to the high mortality of alcoholic (AH) . infection generally self-healing in previously healthy people, but it fatal effects some high-risk groups increase its virulence infectivity. Disseminated infection-induced multiple organ dysfunction syndrome (MODS) patients with AH has not been reported yet. Here, we described viremia an adult patient accompanied by hemolytic anemia (HA), leading disseminated secondary...
Background and Aims: NOD-like receptor thermal-protein domain related protein (NLRP3) has been considered as important response to virus bacteria infection.This study aims investigate compare the effect of NLRP3 inflammasome between pneumonia in early phase caused by influenza A H1N1(H1N1) methicillin-resistant staphylococcus aureus(MRSA).Methods: Pneumonia intranasal inoculation with IAV H1N1 MRSA respectively mice was established.After infected for
<b>Background and Aims:</b> Secondary methicillin resistant staphylococcus aureus (MRSA) infection enhances severity of viral pneumonia with high mortality during influenza A virus (IAV) pandemics. There were abundant researches found that NLRP3 inflammasome in macrophages played an important role mediating inflammation immunity by means IL-1β both IAV MRSA respectively. However, the detailed activity effect aggravated pathology lung secondary to remain under debate. <b>Methods:</b> was...
<b>Background and Aims:</b> Influenza A virus (IAV) is the major cause of severe viral pneumonia. The NLRP3 inflammasome in macrophages has been found essential for responsing against IAV infection. pathology immunity infection are self-limited to within one week commonly. Meanwhile, researches that inflammation induced by early later stage was under debate. This study aims investigate detailed activity role during vitro. <b>Methods:</b> After mouse were cultured infected with H1N1 6 hours...
Aim: The aim of this study was to investigate the activity NLRP3 inflammasome and its effect on inducing severe pneumonia 1 week after influenza A virus (IAV) infection. Materials & methods: expression levels NLRP3, caspase-1 IL-1β were assessed in murine macrophages stimulated with IAV. And severity viral mice explored. Results conclusion: data showed that although diverged, enhanced IAV infection, more associated serum. It infers induces augmented a NLRP3-independent way,
<b>Background:</b> Alveolar macrophages (AMs) are the major immunocytes in lung. Panton-Valentine leukocidin (PVL) causes an inflammatory response AMs, and Toll-like receptor 2 (TLR2) is key receptor. However, PVL also necrosis of AMs. The mechanism by which exerts its effect on pathogenesis to distinguish between a pro-inflammatory necrotic not completely understood <b>Methods:</b> Recombinant (rPVL) were prepared genetic engineering. Limulus test was applied exclude impact LPS. Human AMs...
<b>Background:</b> Influenza A virus (IAV) causes seasonal flu, or even great pandemics in the world. The NLRP3 inflammasome macrophages has been found essential for responding against IAV infection. Severe viral pneumonia usually occurs at later stage, which is about one week, of However, activity and role inflammasome at stage infection remain under debate. <b>Methods:</b> H1N1 FM1 strain, murine and mice were applied.Groups set as blank group, early (6h vitro 24h mice) (1w)...