A5051768908- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Periodontal Regeneration and Treatments
- Proteoglycans and glycosaminoglycans research
- 3D Printing in Biomedical Research
- Intraocular Surgery and Lenses
- Collagen: Extraction and Characterization
- Retinopathy of Prematurity Studies
- Advanced Drug Delivery Systems
- Silk-based biomaterials and applications
- Advanced Sensor and Energy Harvesting Materials
- Polymer Surface Interaction Studies
- Wound Healing and Treatments
- Surgical Sutures and Adhesives
- Mesenchymal stem cell research
- Ophthalmology and Visual Impairment Studies
- Advancements in Transdermal Drug Delivery
- Facial Rejuvenation and Surgery Techniques
Stanford University
2016-2025
VA Palo Alto Health Care System
2016-2025
Smith-Kettlewell Eye Research Institute
2013-2024
Gachon University
2021-2024
Yeouido St. Mary's Hospital
2024
The California Eye Institute
2022
Stanford Medicine
2022
Palo Alto Institute
2021
Santa Clara Valley Medical Center
2016-2020
Tilganga Institute of Ophthalmology
2020
Interpenetrating polymer networks (IPNs) have been the subject of extensive study since their advent in 1960s. Hydrogel IPN systems garnered significant attention last two decades due to usefulness biomedical applications. Of particular interest are mechanical enhancements observed "double network" which exhibit nonlinear increases fracture properties despite being composed otherwise weak polymers. We built upon pioneering work this field as well responsive develop an system based on...
We demonstrate smart contact lenses for noninvasive and continuous diabetic diagnosis retinopathy therapy.
Smart contact lenses for continuous glucose monitoring (CGM) have great potential huge clinical impact. To date, their development has been limited by challenges in accurate detection of without hysteresis tear to track the blood levels. Here, long-term robust CGM diabetic rabbits is demonstrated using bimetallic nanocatalysts immobilized nanoporous hydrogels smart lenses. After redox reaction oxidase, facilitate rapid decomposition hydrogen peroxide and nanoparticle-mediated charge transfer...
Abstract Severe corneal injuries often result in permanent vision loss and remain a clinical challenge. Human bone marrow-derived mesenchymal stem cells (MSCs) their secreted factors (secretome) have been studied for antiscarring, anti-inflammatory, antiangiogeneic properties. We aimed to deliver lyophilized MSC secretome (MSC-S) within viscoelastic gel composed of hyaluronic acid (HA) chondroitin sulfate (CS) as way enhance re-epithelialization reduce complications after mechanical chemical...
To compare clinical assessment of diabetic eye disease by standard dilated examination with data gathered using a smartphone-based store-and-forward teleophthalmology platform.100 eyes 50 adult patients diabetes from health care safety-net ophthalmology clinic. All underwent comprehensive ophthalmic examination. Concurrently, smartphone was used to estimate near visual acuity and capture anterior posterior segment photographs, which masked, standardized review. Quantitative comparison clinic...
Abstract Three‐dimensional (3D) bioprinting is a promising technology to produce tissue‐like structures, but lack of diversity in bioinks major limitation. Ideally each cell type would be printed its own customizable bioink. To fulfill this need for universally applicable bioink strategy, versatile bioorthogonal crosslinking mechanism that compatible and works with range polymers developed. This family materials termed UNIversal, Orthogonal Network (UNION) bioinks. As demonstration UNION...
To validate a vascular severity score as an appropriate output for artificial intelligence (AI) Software Medical Device (SaMD) retinopathy of prematurity (ROP) through comparison with ordinal disease labels stage and plus assigned by the International Classification Retinopathy Prematurity, Third Edition (ICROP3), committee.Validation study AI-based ROP score.A total 34 experts from ICROP3 committee.Two separate datasets 30 fundus photographs each (0-5) (plus, preplus, neither) were labeled...
Corneal defects can lead to stromal scarring and vision loss, which is currently only treatable with a cadaveric corneal transplant. Although in situ-forming hydrogels have been shown foster regeneration of the cornea setting defects, cross-linking, biomechanical, compositional parameters that optimize healing not yet established. This, are also almost universally inflamed, their rapid closure without fibrosis critical preserving vision. Here, an situ forming, bioorthogonally cross-linked,...
Abstract Visually significant corneal injuries and subsequent scarring collectively represent a major global human health challenge, affecting millions of people worldwide. Unfortunately, less than 2% patients who could benefit from sight-restoring transplant have access to cadaveric donor tissue. Thus, there is critical need for new ways repair defects that drive proper epithelialization stromal remodeling the wounded area without cadeveric corneas. Emerging therapies replace corneas...
In this study, an in situ forming corneal stromal substitute based on collagen type I crosslinked by bio-orthogonal strain-promoted azide-alkyne cycloaddition (SPAAC) is presented. The gel has greater transparency compared to non-crosslinked gels. mechanical properties of the gels are controlled changing functional group ratios and conjugated concentrations. Higher concentrations yield enhances properties, where storage modulus increases from 42.39 ± 8.95 112.03 3.94 Pa after SPAAC...
Timely treatment of corneal injuries injury can help to prevent scarring, blindness, and the need for transplantation. This work describes a novel hydrogel that fill defects assist in regeneration. is simultaneous interpenetrating polymer network (IPN) composed collagen cross-linked via strain-promoted azide–alkyne cycloaddition reaction hyaluronic acid thiol–ene Michael click reaction. The formation IPN gel was confirmed FTIR spectra, UV–vis morphological changes. We compared gelation time,...
Continuous intraocular pressure (IOP) monitoring can provide a paradigm shift in the management of patients with glaucoma as facile alternative to conventional diagnostic methods. However, low sensitivity and functional instability current IOP sensors have limited their clinical utility glaucoma. Here, we developed smart contact lens integrated transparent silver nanowire strain sensor wireless circuits for noninvasive, continuous monitoring. After confirming robust stability within presence...
Microextrusion-based 3D bioprinting into support baths has emerged as a promising technique to pattern soft biomaterials complex, macroscopic structures. It is hypothesized that interactions between inks and baths, which are often composed of granular microgels, can be modulated control the microscopic structure within these macroscopic-printed constructs. Using printed collagen bioinks crosslinked either through physical self-assembly or bioorthogonal covalent chemistry, it demonstrated...