A5091409952- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- BRCA gene mutations in cancer
- Breast Cancer Treatment Studies
- Nutritional Studies and Diet
- Cervical Cancer and HPV Research
- Breast Lesions and Carcinomas
- Thyroid Disorders and Treatments
- Colorectal Cancer Screening and Detection
- Cardiovascular Health and Risk Factors
- Nutrition, Genetics, and Disease
- Alcohol Consumption and Health Effects
- Injury Epidemiology and Prevention
- Folate and B Vitamins Research
- Pancreatitis Pathology and Treatment
- Prostate Cancer Treatment and Research
- Selenium in Biological Systems
- Bone health and treatments
- Emergency and Acute Care Studies
- Growth Hormone and Insulin-like Growth Factors
- Radiopharmaceutical Chemistry and Applications
- Gallbladder and Bile Duct Disorders
- Trauma and Emergency Care Studies
- Appendicitis Diagnosis and Management
- Gastric Cancer Management and Outcomes
St. Augustine International University
2019-2023
Makerere University
2014-2018
University of Chicago
2013-2018
Mulago Hospital
2006-2015
Institute of Human Virology
2013
University of Maryland, Baltimore
2013
University of Ibadan
2013
The objective was to investigate survival of breast cancer patients at Mulago Hospital. A retrospective study the medical records 297 referred combined clinic housed in radiotherapy department between 1996 and 2000 done. female/male ratio 24 : 1. age range 22–85 years, with a median 45 years peak group 30–39 years. Twenty-three percent had early disease (stages 0–IIb) 26% metastatic disease. Poorly differentiated most common pathological grade (58%) followed by moderately (33%)...
Sub-Saharan Africa (SSA) has a high proportion of premenopausal hormone receptor negative breast cancer. Previous studies reported strikingly prevalence germline mutations in BRCA1 and BRCA2 among Nigerian patients with It is unknown if this exists other SSA countries.Breast cancer cases, unselected for age at diagnosis family history, were recruited from tertiary hospitals Kampala, Uganda Yaoundé, Cameroon. Controls women without the same age-matched to cases. A multigene sequencing panel...
Background Alcohol drinking is linked to the development of breast cancer. However, there little knowledge about impact alcohol consumption on cancer risk among African women. Methods We conducted a case-control study 2,138 women with invasive and 2,589 controls in Nigeria, Cameroon, Uganda from 1998 2013. A structured questionnaire was used collect information consumption, defined as consuming alcoholic beverages at least once week for six months or more. Logistic regression estimate...
Physical activity (PA) is modifiable and linked to decreased breast cancer risk but its impact has not been investigated among indigenous African populations.From 2011 2013, 558 cases 1,014 controls were recruited into the Breast Cancer Study in Nigeria, Cameroon, Uganda, completed a culturally tailored PA questionnaire that assesses habitual year before diagnosis/interview. sub-scores (housework, occupational, leisure PA) total score calculated (metabolic equivalent of task, MET-hours/day)....
BACKGROUND The breast cancer (BC) risk profiles of African women differ significantly from those European ancestry. are younger at the age onset and tend to have high parity. purpose this study was examine relationship between full‐term pregnancy (FTP) BC. METHODS A case‐control conducted among 1995 with invasive BC 2631 controls in Nigeria, Cameroon, Uganda. Odds ratios (ORs) for individual ages FTP according time since delivery were calculated adjusted confounders. fitted spline model used...
Introduction. Mastalgia is a common breast condition among women referred to clinics worldwide. Whereas the prevalence known in Western world and Asia, of disease unknown many African countries. The aim this study therefore was determine describe factors associated with mastalgia attending tertiary hospital sub-Saharan Africa. Methods. A cross-sectional done Kampala, Uganda. defined as self-reported pain (unilateral or bilateral) for period not less than two months. pretested questionnaire...
The Nigerian Breast Cancer Study (NBCS) model is a new risk assessment tool developed for predicting of invasive breast cancer in Nigeria. Its applicability outside Nigeria remains uncertain as it has not been validated other sub-Saharan Africa populations.We conducted case-control study among women with and controls ascertained Cameroon Uganda from 2011 to 2016. Structured questionnaire interviews were performed collect factor characteristics. NBCS model, the Gail Black population, Women's...
Abstract Purpose: To determine the association between benign breast disease (BBD) and cancer if BBD is a mediator of established risk factors among native African women Methods: We analysed data from 5154 who participated in case control study (2405 cases 2749 controls) March 1998 December 2014 three sub Saharan countries: Nigeria (n= 4233), Uganda (n=477) Cameroon (n=444). Breast aged 18 years older were enrolled two tertiary hospitals countries, unselected for age at diagnosis family...
Purpose: To determine the association between benign breast disease (BBD) and cancer if BBD is a mediator of established risk factors among native African womenMethods: We analysed data from 5154 women who participated in case control study (2405 cases 2749 controls) March 1998 December 2014 three sub Saharan countries: Nigeria (n= 4233), Uganda (n=477) Cameroon (n=444). Breast aged 18 years older were enrolled two tertiary hospitals countries, unselected for age at diagnosis family history....
comprehensive cancer risk assessment services are lacking in most sub-Saharan African countries and the use of accurate family history (FH) information could serve as a cheap strategy for evaluation. The aim this study is to determine proportion women unaware among female relatives associated socio-demographic characteristics.using case-control data on breast 4294 Nigeria, Uganda Cameroon, we investigated their relatives. association between participants' response awareness relatives'...
Abstract Background African women affected by breast cancer (BC) have high parity with five children or more, are relatively young at first full term pregnancy (FFTP), diagnosed a age and often premenopausal diagnosis. While several studies assessed the role of reproductive factors for BC risk among women, none them whether there is dual effect (FTP). In this communications, using large dataset from an on-going hospital-based case-control study, we examine on women. Methods The study...
Abstract Background: As a modifiable risk factor, physical activity (PA) has been linked to breast cancer, and there is cumulative evidence for beneficial effect of PA on cancer risk. However, most the studies were conducted in developed countries, with little knowledge level its relation among indigenous African populations, where may have unique etiology. Methods: We used preliminary data from Breast Cancer Study (ABCS), recently launched, multicenter case-control study, Cameroon, Nigeria,...
Background: Breast cancer among indigenous Africans is characterized by higher prevalence of triple-negative disease and poor prognosis. A previous study in Nigeria reported a strikingly high deleterious germline mutations BRCA1 BRCA2 Nigerian women with breast cancer. It unknown if this true other sub-Saharan African countries. Aim: The objective to determine the frequency an unselected sample Africa. Methods: We conducted case-control Uganda Cameroon investigate genetic nongenetic risk...
Abstract Background: Women of African ancestry across the diaspora have low risk developing breast cancer compared to women European ancestry. However, they suffer highest mortality rates because disproportionate burden young onset aggressive hormone receptor negative cancer. To implement strategies for early detection and prevention, it is critically important develop better assessment tools. The Nigerian Breast Cancer Study (NBCS) model a new tool developed individual estimation absolute...