A5062210003- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Cancer survivorship and care
- BRCA gene mutations in cancer
- COVID-19 and healthcare impacts
- Cancer Treatment and Pharmacology
- Economic and Financial Impacts of Cancer
- Complementary and Alternative Medicine Studies
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- AI in cancer detection
- Single-cell and spatial transcriptomics
- Cancer Risks and Factors
- Telemedicine and Telehealth Implementation
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- RNA Research and Splicing
- Blockchain Technology Applications and Security
- Palliative Care and End-of-Life Issues
- Cardiovascular Health and Risk Factors
- Acupuncture Treatment Research Studies
- Green IT and Sustainability
Peking University
2024
Chicago Department of Public Health
2020-2024
University of Chicago
2018-2024
Institute of Computing Technology
2024
Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2024
Sun Pharma (India)
2024
Cancer Genetics (United States)
2024
Novartis (Switzerland)
2024
Color (United States)
2024
Importance Given conflicting results regarding the prognosis of erb-b2 receptor tyrosine kinase 2 (ERBB2; formerly HER2 or HER2/neu)–low breast cancer, a large-scale, nationally applicable comparison ERBB2-low vs ERBB2-negative cancer is needed. Objective To investigate whether clinically distinct subtype in terms epidemiological characteristics, prognosis, and response to neoadjuvant chemotherapy. Design/Participants/Setting This retrospective cohort study was conducted using National...
<h3>Importance</h3> Despite data aggregation and removal of protected health information, there is concern that deidentified physical activity (PA) collected from wearable devices can be reidentified. Organizations collecting or distributing such suggest the aforementioned measures are sufficient to ensure privacy. However, no studies, our knowledge, have been published demonstrate possibility impossibility reidentifying data. <h3>Objective</h3> To evaluate feasibility accelerometer-measured...
Importance With the increasing delivery of neoadjuvant chemotherapy (NACT) for patients with breast cancer in US, it is important to know whether there differential response NACT by race and ethnicity potential long-term outcomes. Objective To examine were any racial ethnic differences pathologic complete (pCR) rate following and, if so, they varied molecular subtype associated survival. Design, Setting, Participants A retrospective cohort study was conducted including stage I III diagnosed...
Importance Among patients with breast cancer, inconsistent findings have been published on racial disparities in achieving pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT). Objective To investigate whether exist pCR and what factors contribute to them. Design, Setting, Participants Within the ongoing Chicago Multiethnic Epidemiologic Breast Cancer Cohort (ChiMEC), which consists of a prospectively ascertained cohort 690 stage I III cancer receiving NACT were...
Distributed renewable energy offers an exciting opportunity for sustainable transition and climate change mitigation. However, it is overlooked in most of the conventional tradable green certificates programs. Blockchain shows advantage incorporating a galaxy distributed prosumers transparent low-cost manner. This paper proposes I-Green, blockchain-based individual system promoting voluntary adoption energy. Combing features blockchain technology theories social norm peer effects, novel...
Abstract Background Endocrine-resistant HR+/HER2- breast cancer (BC) and triple-negative BC (TNBC) are of interest for molecularly informed treatment due to their aggressive natures limited profiles. Patients African Ancestry (AA) experience higher rates TNBC mortality than European (EA) patients, despite lower overall incidence. Here, we compare the molecular landscapes AA EA patients with in a real-world cohort promote equity precision oncology by illuminating heterogeneity potentially...
As the coronavirus disease 2019 (COVID-19) pandemic continues to spread, it remains unclear how vulnerable populations with preexisting health conditions like cancer have been affected. Between July and September of 2020, authors conducted a cross-sectional study that surveyed 2661 patients breast who were registered in Chicago Multiethnic Epidemiologic Breast Cancer Cohort received 1300 responses (71.5% White 22.4% Black patients). The survey measured psychosocial well-being participants...
Abstract Polygenic risk scores (PRSs) are useful for predicting breast cancer risk, but the prediction accuracy of existing PRSs in women African ancestry (AA) remains relatively low. We aim to develop optimal overall and estrogen receptor (ER) subtype-specific AA women. The dataset comprised 9235 cases 10 184 controls from four genome-wide association study (GWAS) consortia a GWAS Ghana. randomly divided samples into training validation sets. built using individual-level data by forward...
There are a paucity of data and pressing need to evaluate response neoadjuvant chemotherapy (NACT) determine long-term outcomes in young Black women with early-stage breast cancer (EBC).We analyzed from 2196 White EBC treated at the University Chicago over last 2 decades. Patients were divided into groups based on race age diagnosis: [Formula: see text] 40 years, 55 years. Pathological complete rate (pCR) was using logistic regression. Overall survival (OS) disease-free (DFS) Cox...
To externally evaluate a mammography-based deep learning (DL) model (Mirai) in high-risk racially diverse population and compare its performance with other mammographic measures. A total of 6435 screening mammograms 2096 female patients (median age, 56.4 years ± 11.2 [SD]) enrolled hospital-based case-control study from 2006 to 2020 were retrospectively evaluated. Pathologically confirmed breast cancer was the primary outcome. Mirai scores predictors. Breast density Imaging Reporting Data...
Palliative care improves cancer patients' quality of life. Limited research has investigated racial/ethnic disparities in palliative utilization and its associated survival among metastatic breast (MBC) patients.
Spatially resolved transcriptomics (SRT) technologies have revolutionized the study of tissue organization. We introduce a graph convolutional network with an attention and positive emphasis mechanism, termed BINARY, relying exclusively on binarized SRT data to accurately delineate spatial domains. BINARY outperforms existing methods across various types while using significantly less input information. Our suggests that precise gene expression quantification may not always be essential,...
Abstract Given high costs of Oncotype DX (ODX) testing, widely used in recurrence risk assessment for early-stage breast cancer, studies have predicted ODX using quantitative clinicopathologic variables. However, such models incorporated only small cohorts. Using a cohort patients from the National Cancer Database (NCDB, n = 53,346), we trained machine learning to predict low-risk (0-25) or high-risk (26-100) estrogen receptor (ER)/progesterone (PR)/Ki-67 status, ER/PR status alone, and no...
Blockchain, as an emerging technology and a disruptive innovation, has attracted attention from both academia industry. However, there are many potential risks associated with it, such the technical risk, legal risk privacy risk. A comprehensive analysis is crucial for cost-effective deployment of blockchain technology. Important adoption decisions, including when to deploy blockchain, how plan investment, transfer current businesses onto price service depend on this analysis. Yet very...
Abstract Objectives To validate an appropriate evaluation method of liver fibrosis assessment based on the unique pathological features biliary atresia (BA) that could well predict its prognosis. Methods A total 68 patients with BA who underwent Kasai procedure (KP) and intraoperative biopsy, followed up from January 2019 to December 2021, were recruited in a retrospective analysis. Ishak, Metavir, BA-specific staging systems relation outcomes analyzed using logistic regression, COX...
Abstract Background Guidelines recommend the use of genomic assays such as OncotypeDx to aid in decisions regarding chemotherapy for hormone receptor–positive, HER2‐negative (HR+/HER2−) breast cancer. The RSClin prognostic tool integrates and clinicopathologic features predict distant recurrence benefit, but further validation is needed before broad clinical adoption. Methods This study included patients from National Cancer Data Base (NCDB) who were diagnosed with stage I–III HR+/HER2−...
Abstract Background: Patient-reported outcomes (PRO) assess symptom burden and health-related quality of life (HRQL) more accurately than clinical report. We previously found that treatment-emergent adverse events (CTCAE V3.0) did not impact efficacy in the main NCIC MA.27 trial, although many women discontinued treatment early. The purpose this substudy was to obtain PROs MA.27/E1Z03 participants evaluate treatment-related side effects HRQL between exemestane anastrozole identify predictors...
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Breast cancer (BC) with chest wall metastasis (CWM) usually shows rich neovascularization. This trial explored the clinical effect of apatinib on human epidermal growth factor receptor 2 (HER2)-negative advanced BC involving CWM.This involved four centers in China and was conducted from September 2016 to March 2020. Patients received 500 mg/d [either alone or endocrine therapy if hormone receptor-positive (HR+)] until disease progression unacceptable toxicity. Progression-free survival (PFS)...