A5007834411- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Fiscal Policy and Economic Growth
- Breast Cancer Treatment Studies
- Colorectal Cancer Screening and Detection
- Economic and Financial Impacts of Cancer
- Advances in Oncology and Radiotherapy
- Health Systems, Economic Evaluations, Quality of Life
- Advanced biosensing and bioanalysis techniques
- Economic Growth and Development
- Genomic variations and chromosomal abnormalities
- Endometrial and Cervical Cancer Treatments
- Cancer Diagnosis and Treatment
- Genetics, Bioinformatics, and Biomedical Research
- Male Breast Health Studies
- Interprofessional Education and Collaboration
- Energy, Environment, Economic Growth
- Cancer Risks and Factors
- Religion and Sociopolitical Dynamics in Nigeria
- Working Capital and Financial Performance
- Genomics and Rare Diseases
- Gynecological conditions and treatments
Lagos State University
2012-2024
Lagos State University Teaching Hospital
2012-2023
Ahmadu Bello University
2017-2022
University of Ibadan
2014-2017
University of Chicago
2016-2017
Novartis (United States)
2016-2017
Center for Global Health
2017
Institute for Advanced Medical Research
2016
Abstract Racial/ethnic disparities in breast cancer mortality continue to widen but genomic studies rarely interrogate diverse populations. Through genome, exome, and RNA sequencing, we examined the molecular features of cancers using 194 patients from Nigeria 1037 The Cancer Genome Atlas (TCGA). Relative Black White cohorts TCGA, Nigerian HR + /HER2 − tumors are characterized by increased homologous recombination deficiency signature, pervasive TP53 mutations, greater structural...
Abstract Black women across the African diaspora experience more aggressive breast cancer with higher mortality rates than white of European ancestry. Although inter-ethnic germline variation is known, differential somatic evolution has not been investigated in detail. Analysis deep whole genomes 97 cancers, RNA-seq a subset, from Nigeria comparison The Cancer Genome Atlas (n = 76) reveal rate genomic instability and increased intra-tumoral heterogeneity as well unique subtype defined by...
While the physical complications of breast cancer are often recognized and well managed, psychological sequelae, especially depression unrecognized by healthcare providers therefore under treated. This study aimed to assess rate correlate depressive disorders in survivors Lagos, Nigeria.Patients (n = 124) recruited from a outpatient clinic were assessed for DSM-IV diagnosis using Mini International Neuropsychiatric Interview (MINI). The staging cancer, length treatment type recorded. Also...
Background Globally, cancer is a major leading health problem with an estimated 10 million incidences and 6 deaths annually. In Nigeria, 72,000 occur annually, 102,000 new cases are diagnosed from its population of 200 people. These are, however, estimates, it necessary to document the yearly trends patterns mortality regards different regions in country. Methodology we conducted this study at Lagos State University Teaching hospital (LASUTH), Ikeja, 2009 2018. Data extracted included those...
Somatic mutation signatures may represent footprints of genetic and environmental exposures that cause different cancer. Few studies have comprehensively examined their association with germline variants, none in an indigenous African population. SomaticSignatures was employed to extract based on whole‐genome or whole‐exome sequencing data from female patients breast cancer (TCGA, training set, n = 1,011; Nigerian samples, validation 170), estimate contributions each sample. Association...
The study examined the effect of equity financing on financial performance listed deposit money banks in Nigeria. Return Assets was used as a measure while share capital, retained earnings, and other reserves were independent variables. Data for obtained from audited annual reports 14 sampled period 10 years covering 2009 to 2018. employed robust ordinary least square regression tool analysis testing hypotheses based Hausman specification test. result reveals that capital has positive...
PURPOSE There are strategies to bring quality cancer care underserved patients, but poor use of the principles teamwork is a major barrier achieving services. The intent this study was assess as perceived by health workers caring for patients with cancer. METHODS We conducted survey among professionals in at 3 tertiary centers southwestern Nigeria from July November 2016. Respondents rated using Safety Attitudes Questionnaire; we focused on climate subscale comparing providers and...
Introduction: Late presentation is the hallmark of breast cancer among Nigerians. Awareness disease low and care this condition has not received adequate attention from Government. Health education to improve awareness was intensified in last 2 decades. This study aims assess current state Lagos, Nigeria. Patients Methods: A prospective 350 patients seen over a period four years at General Surgical unit out-patient clinic LASUTH carried out. Data on patient characteristics, presentation,...
PURPOSE Cancer genetic testing (CGT), a pathway to personalized medicine, is also being embraced in Nigeria. However, little known about the influence of demographics and perceptions on individuals' willingness access pay for CGT. This study assessed patients' undergo CGT southwest Nigeria as catalyst sustainable Risk Management Program. METHODS was cross-sectional using semistructured questionnaire interview 362 patients with cancer 10 referred first-degree relatives between July 2018...
Aim:The objective is to describe the age and gender distribution, pattern of presentation, sites colorectal cancers histological types seen over a 5 year period in tertiary health institution (Lagos State University Teaching Hospital, Nigeria).Design: A collected data 104 patients with cancer from 2006 2011 formed basis this study.Results: Sixty-five were males thirty-nine female out cases.Age range was between 19 78 years.The male ratio 1.3:1.28.8% (30) presented stage IV, 46.1 (48) III,...
Background: Breast cancer is one of the most common malignant diseases in women and adjuvant combination chemotherapy has been shown to reduce mortality from this disease. Adherence medical treatment a multifaceted issue that can substantially alter outcomes therapy. Patient non-adherence ultimate barrier effectiveness. Objective: This study was carried out determine relationship between adherence breast staging, patient’s perception care socio-demographic characteristics. Material method:...
Background: This study was initiated to determine practices patterns in adjuvant chemotherapy for non-metastatic breast cancer and examine the relationship between received dose intensity (RDI) survival patients with Nigeria. Methods: Our a retrospective analysis of recruited from 2012 2015. A total 204 were initially entered into study, 102 lost follow-up leaving who suitable analysis. Survival time calculated 106 days, scheduled end chemotherapy. Results: The average RDI 74%. Over that...
Abstract Objectives: Paucity of data on populations African Ancestry in clinical trials continues to limit our ability design and implement innovative solutions narrow the breast cancer survival gap amongst Africans, Americans, European Americans. We have developed a cross-continent research infrastructure examine spectrum genomic alterations tumors from West Africa subsequently, compare them American women The Cancer Genome Atlas (TCGA) database. Methods: Consecutive with presenting for...
e18106 Background: In low middle-income countries (LMICs), cancer patients present in later stages of disease for many reasons, including missed diagnoses. Due to high patient: physician ratios, generalists are taught broadly and prepared treat diseases outside the scope their interest training. The delivery high-quality care requires an interdisciplinary team physicians with excellent medical school training oncology. To date, there has been no formal assessment education oncology Nigeria....
Background: This study was done to evaluate the histological types, frequency and age distribution of ovarian tumours in Lagos State University Teaching Hospital (LASUTH), Ikeja, State. also aims classify this centre according World Health Organisation (WHO).Methods: A retrospective, descriptive hospital all specimens that were sent department pathology forensic medicine, LASUTH between 1st January, 2011 31st December, 2019 done. Relevant data composed distributions histopathological types...