A5046345758- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Parasites and Host Interactions
- Parasitic Infections and Diagnostics
- Galectins and Cancer Biology
- Tuberculosis Research and Epidemiology
University of Pennsylvania
2019-2024
Intestinal epithelial cells (IEC) have important functions in nutrient absorption, barrier integrity, regeneration, pathogen-sensing, and mucus secretion. Goblet are a specialized cell type of IEC that secrete Trefoil factor 3 (TFF3) to regulate viscosity wound healing, but whether TFF3-responsiveness requires receptor is unclear. Here, we show leucine rich repeat nogo-interacting protein 2 (LINGO2) essential for TFF3-mediated functions. LINGO2 immunoprecipitates with TFF3, co-localizes TFF3...
Host defense at the mucosal interface requires collaborative interactions between diverse cell lineages. Epithelial cells damaged by microbial invaders release reparative proteins such as Trefoil factor family (TFF) peptides that functionally restore barrier integrity. However, whether TFF and their receptors also serve instructive roles for immune function during infection is incompletely understood. Here, we demonstrate intestinal trefoil factor, TFF3, restrains (T helper) T
Abstract T helper type 2 (TH2) cells are critical for clearance of parasitic helminth infections. Their coordinated efforts harness cellular and molecular pathways to expel worms, resolve intestinal inflammation drive tissue repair. Yet the mechanisms that control TH2 cell activation, maintenance, downregulation remain unknown. We recently demonstrated Leucine rich repeat Ig domain containing (LINGO2) can function as a receptor mucosal reparative cytokine, Trefoil factor 3, limit epithelial...