A5101873296- Phytoestrogen effects and research
- Medicinal plant effects and applications
- Phytochemicals and Antioxidant Activities
- Advanced Glycation End Products research
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Antioxidant Activity and Oxidative Stress
- Diet, Metabolism, and Disease
Army Medical University
2011-2025
BACKGROUND Anthocyanins have been shown to improve endothelial function in animal models. However, whether these compounds similar beneficial effects humans is largely unknown. METHODS In a short-term crossover study, 12 hypercholesterolemic individuals were given oral anthocyanins (320 mg) isolated from berries or placebo. Brachial artery flow-mediated dilation (FMD) was assessed before and after the intervention. long-term intervention trial (12 weeks), 150 mg/day, n = 75) placebo (n 75),...
Abstract Increasing evidence demonstrates that pyroptosis, pro‐inflammatory programmed cell death, is linked to atherosclerosis; however, the underlying mechanisms remain be elucidated. Dihydromyricetin (DHM), a natural flavonoid, was reported exert anti‐oxidative and anti‐inflammatory bioactivities. However, effect of DHM on atherosclerosis‐related pyroptosis has not been studied. In present study, palmitic acid (PA) treatment led in human umbilical vein endothelial cells (HUVECs), as...
High-intensity exercise (HIE) induces liver dysfunction and is detrimental to performance. The underlying mechanism preventive strategy urgently need be explored. We increased the amount of tryptophan appropriately in diet explored effect an L-tryptophan-rich on alleviation HIE-induced mechanism. In this work, by establishing a C57BL/6 mouse model high-intensity swimming exercise, results demonstrated significantly attenuated dysfunction, which was associated with levels metabolite...
Abstract Background S-Equol , produced from daidzein by gut microbiota, has been suggested as an potential anti-diabetic agent, but the underlying mechanisms remain unclear. Recent evidences demonstrated that carbohydrate response element-binding protein (Chrebp)/Thioredoxin-interacting (Txnip) signaling played central roles on diabetes progression, particularly in relation to function maintenance and apoptosis of pancreatic β-cell. Here, we investigated effects β-cell Chrebp/Txnip . Methods...