A5054374381- Meteorological Phenomena and Simulations
- Medicinal Plants and Neuroprotection
- Climate variability and models
- Dermatology and Skin Diseases
- Inflammatory Bowel Disease
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Advanced Chemical Sensor Technologies
- Chemokine receptors and signaling
- Aeolian processes and effects
- MicroRNA in disease regulation
- Pharmacological Effects of Medicinal Plants
- Effects of Radiation Exposure
- Obstructive Sleep Apnea Research
- Folate and B Vitamins Research
- Sphingolipid Metabolism and Signaling
- Pregnancy and preeclampsia studies
- Dementia and Cognitive Impairment Research
- Cancer, Stress, Anesthesia, and Immune Response
- Oral health in cancer treatment
- Metastasis and carcinoma case studies
- Atmospheric aerosols and clouds
- Immunotherapy and Immune Responses
- Alzheimer's disease research and treatments
- Ginger and Zingiberaceae research
Beihua University
2023
University of Benin
2023
Lianyungang Oriental Hospital
2022
Xuzhou Medical College
2022
China Medical University
2009-2022
Vanderbilt University Medical Center
2018
China General Nuclear Power Corporation (China)
2017
Purdue University West Lafayette
2016
ChemoCentryx (United States)
2008-2013
Jilin University
2008
Abstract Background The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion dementia. Methods Three multicenter cohorts of cognitively healthy elderly, mild cognitive impairment (MCI), AD participants standardized clinical assessments structural neuroimaging were used. Twenty‐six candidate proteins quantified 1148 subjects...
The chemokine system represents a diverse group of G protein-coupled receptors responsible for orchestrating cell recruitment under both homeostatic and inflammatory conditions. Chemokine receptor 9 (CCR9) is known to be central migration immune cells into the intestine. Its only ligand, CCL25, expressed at mucosal surface intestine elevated in intestinal inflammation. To date, there are no reports small-molecule antagonists targeting CCR9. We report, first time, discovery small molecule,...
Chemokine (C-C motif) receptor 2 (CCR2) is central for the migration of monocytes into inflamed tissues. The novel CCR2 antagonist CCX140-B, which currently in two separate phase clinical trials diabetic nephropathy, has recently been shown to reduce hemoglobin A1c and fasting blood glucose levels type diabetics. In this report, we describe effects compound on glycemic renal function parameters mice. Since CCX140-B a low affinity mouse CCR2, transgenic human knockin mice were generated...
Background Asymmetry in motor dysfunction and associated dopaminergic deficit is a common characteristic of Parkinson's disease (PD), yet potential explanations remain mysterious. Hereby, we assessed whether asymmetry the nasal cavity related to PD patients. Methods This cross-sectional, multi-center observational study included 761 patients from three cohorts. First, analyzed data Huashan Parkinsonian PET Imaging Database (March 2011 February 2020), which served as primary cohort (n=333)....
IL-4 and IL-13 signaling via IL-4Rα plays key roles in the pathogenesis of atopic dermatitis (AD) asthma. Rademikibart (formerly CBP-201), a next-generation human IgG4 kappa monoclonal antibody, blocks IL-4Rα-mediated signal transduction. We performed two phase I, randomized, double-blind, placebo-controlled trials. In single-ascending dose trial, 40 healthy adults were randomized 3:1 to rademikibart (75-600 mg s.c., 300 i.v.) or placebo, with 12 weeks follow-up. multiple-ascending 31...
ABSTRACT A tornado climatology in China was derived based on a recently completed data set with details 4763 tornadoes the period 1948–2012. The were rated Fujita scale, and design basis wind speeds estimated. Annual estimated 108 (±44) China, among which 0–4 exceed F3 scale. Three strongest F4. Assessing from frequency distribution of ratings, could be mostly non‐supercell type. In average all country, most occur summer (June–August, about 64%). peak month is July (31%). Geographically,...
As the population ages, incidence of clinical dementia has been rising around world. It reported that microRNAs act as key diagnostic biomarkers and targets for various neurological conditions, including dementia. MiR-322-5p revealed to play an important role in multiple diseases. In this study, we aimed investigate regulatory mechanism miR-322-5p vascular dementia.In neonatal rat neurons (NRNs) were subjected oxygen-glucose deprivation/reoxygenation (OGD/R) induce cell injury. The animals...
To identify laboratory markers among platelet indices, coagulation parameters, blood lipid and liver/kidney function variables that can be used to predict preeclampsia.We studied records of 568 women with preeclampsia, gestational hypertension (GH), or normal term pregnancies hospitalized in the Obstetrics Department Fujian Maternal Child Health Hospital from September 2014 2018. We divided patients' into three groups (216 136 hypertension, 216 pregnancies). conducted retrospective analyses...
Background Icanbelimod (formerly CBP-307) is a next-generation S1PR modulator, targeting 1 . In this first-in-human study, icanbelimod was investigated in healthy men Australia. Methods Participants were randomized 3:1, double-blind, to or placebo four single-dose cohorts (0.1 mg, 0.25 0.5 mg [n=8 per cohort], 2.5 [n=4]) for 28-days once-daily treatment two (0.15 cohort]). the 0.25-mg cohort received 0.1 on Day 1. Treatments administered orally after fasting; following one-week washout,...
Tornado is one of the most hazardous external natural events which should be taken into account in siting, design and safety evaluation nuclear power plants. The tornado hazard has been assessed for a plant located Southeast China this paper. Using original Fujita scale grading by number experts, intensities segments have determined. design-basis wind speed, parameters missiles generated evaluated following methodology listed hChinese Nuclear Safety Guide HAD101/10. results show that overall...
Introduction: Manganese (Mn) toxicity can result in cognitive and motor deficits such as manganism, a disorder similar to idiopathic Parkinson's disease. As Mn is stored bone, this may be useful biomarker for cumulative exposure. Our team has developed new, transportable vivo Neutron Activation Analysis (NAA) system capable of noninvasively quantifying bone manganese (BnMn) concentrations. The goals pilot study were demonstrate that estimate BnMn determine whether there correlation with...
Purpose: To investigate analgesic effect and safety of dexmedetomidine combined with ropivacaine in ultrasound-guided brachial plexus block intercostal space.Methods: A total 90 patients were scheduled to undergo upper limb surgery divided into control study groups, respectively. Patients group given nerve block, while those mixture block. The efficiency sensory motor secondary evaluation effect, visual analogue scale (VAS) scores at different postoperative moments, remedial analgesia...
CCR9 is a chemokine receptor known to play pivotal role in migration of T-cells the mucosal surface gut. Ablation or its ligand CCL25/TECK by genetic deletion neutralizing antibodies impairs gut mice. CCL25 be expressed human intestinal mucosa, and up regulated Crohn's Celiac patients.It well established that critical for T-cell homing small intestine. We have recently found also development ulcerative colitis animal models, indicating this cell large bowel. To extend these observations, we...
Background: Never-smoking Chinese women have a high rate of lung cancer but the etiology is poorly understood. This study first to evaluate untargeted urinary metabolome and risk among never-smoking in China. Methods: nested case-control included 275 cases 289 controls from prospective cohort, Shanghai Women's Health Study, comprising 73,363 women. Metabolic profiling chemical features was conducted using ultrahigh-performance liquid chromatography - tandem mass spectrometry (UPLC-MS)...
Abstract Introduction The effectiveness of the contraction UA dilator muscles plays a crucial role in maintenance patency. This study aimed to assess effects one-week velopharyngeal-task training (VTT) on sleep apnea severity and its genioglossus (GG) corticomotor excitability. Methods Ten patients with underwent 1 h VTT seven consecutive days. During protocol, subjects were asked develop repetitive intra-oral positive pressure using cheek-bulging maneuvers while wearing mouth piece keep jaw...