A5027079549- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Microbial Metabolites in Food Biotechnology
- Probiotics and Fermented Foods
- Nutritional Studies and Diet
- Food composition and properties
- Clostridium difficile and Clostridium perfringens research
- Liver Disease Diagnosis and Treatment
- Infant Nutrition and Health
- Metabolism and Genetic Disorders
- Clinical Nutrition and Gastroenterology
- Infant Health and Development
- Mass Spectrometry Techniques and Applications
- Digestive system and related health
- Diet, Metabolism, and Disease
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- GABA and Rice Research
- Health, Environment, Cognitive Aging
- Sodium Intake and Health
- Fatty Acid Research and Health
- Phytoestrogen effects and research
- Coffee research and impacts
- Congenital Heart Disease Studies
- Machine Learning in Healthcare
University of Reading
2017-2025
Food & Nutrition
2021-2023
National Institute for Health Research
2015-2019
Medical Research Council
2019
Imperial College London
2010-2019
The London College
2018
University of Brighton
2016
Royal Brompton & Harefield NHS Foundation Trust
2016
Southampton General Hospital
2016
University Hospital Southampton NHS Foundation Trust
2016
Diet-microbe interactions play an important role in modulating the early-life microbiota, with Bifidobacterium strains and species dominating gut of breast-fed infants. Here, we sought to explore how infant diet drives distinct bifidobacterial community composition dynamics within individual ecosystems. Genomic characterisation 19 isolated from infants revealed a diverse genomic architecture enriched carbohydrate metabolism genes, which was each strain, but collectively formed pangenome...
In a large-scale population-based metabolic phenotyping study, diverse sets of urinary metabolites, including gut microbial co-metabolites, were reproducibly associated with human adiposity.
In renal Fanconi's syndrome, dysfunction in proximal tubular cells leads to losses of water, electrolytes, and low-molecular-weight nutrients. For most types isolated the genetic cause underlying defect remain unknown.We clinically genetically characterized members a five-generation black family with autosomal dominant syndrome. We performed genomewide linkage analysis, gene sequencing, biochemical cell-biologic investigations cells, studies knockout mice, functional evaluations...
The multicomponent analysis of human breast milk (BM) by metabolic profiling is a new area study applied to determining composition, and capable associating BM composition with maternal characteristics, subsequent infant health outcomes. A multiplatform approach combining HPLC‐MS ultra‐performance LC‐MS, GC‐MS, CE‐MS, 1 H NMR spectroscopy was used comprehensively characterize profiles from seventy samples. total 710 metabolites spanning multiple molecular classes were defined. utility the...
Rates of heart disease and stroke vary markedly between north south China. A (1)H NMR spectroscopy-based metabolome-wide association approach was used to identify urinary metabolites that discriminate southern northern Chinese population samples, investigate biomarkers might relate the difference in cardiovascular risk. spectra were acquired from two 24-h urine specimens per person for 523 244 participants INTERMAP Study macro/micronutrients blood pressure. Discriminating identified using...
There is no clinically applicable biomarker for surveillance of hepatocellular carcinoma (HCC), because the sensitivity serum alpha-fetoprotein (AFP) too low this purpose. Here, we determined diagnostic performance a panel urinary metabolites HCC patients from West Africa. Urine samples were collected Nigerian and Gambian recruited on case-control platform Prevention Liver Fibrosis Cancer in Africa (PROLIFICA) program. Urinary proton nuclear magnetic resonance ((1) H-NMR) spectroscopy was...
This study evaluated the effects of locally produced probiotic yogurt on infectious diseases in Ugandan children aged 3–6 years. Over nine weeks, 196 participated a randomized, double-blind, placebo-controlled trial, consuming 125 ml daily either containing Lacticaseibacillus rhamnosus yoba 2012 and Streptococcus thermophilus C106 or non-fermented dairy placebo. The primary outcome, average incidence upper respiratory tract symptoms, showed no significant difference between groups. However,...
Significant advances in understanding aging have been achieved through studying model organisms with extended healthy lifespans. Employing 1H NMR spectroscopy, we characterized the plasma metabolic phenotype (metabotype) of three long-lived murine models: 30% dietary restricted (DR), insulin receptor substrate 1 null (Irs1-/-), and Ames dwarf (Prop1df/df). A panel differences were generated for each relative to their controls, subsequently, models compared one another. Concentrations mobile...
Data indicate an inverse association between dietary calcium and magnesium intakes blood pressure (BP); however, much less is known about associations urinary excretion BP in general populations. The authors assessed the relation of to 24-hour 2 cross-sectional studies. International Study Macro- Micro-Nutrients Blood Pressure (INTERMAP) comprised 4,679 persons aged 40–59 years from 17 population samples China, Japan, United Kingdom, States, Cooperative on Salt, Other Factors, (INTERSALT)...
Large-scale metabolic profiling requires the development of novel economical high-throughput analytical methods to facilitate characterization systemic variation in population phenotypes. We report a fit-for-purpose direct infusion nanoelectrospray high-resolution mass spectrometry (DI-nESI-HRMS) method with time-of-flight detection for rapid targeted parallel analysis over 40 urinary metabolites. The newly developed 2 min <10 μL urine sample and generates MS profiles both positive negative...
Inflammation and metabolism are closely interlinked. Both undergo significant dysregulation following surgery for congenital heart disease, contributing to organ failure morbidity. In this study, we combined cytokine metabolic profiling examine the effect of postoperative tight glycemic control compared with conventional blood glucose management on inflammatory outcomes in children undergoing surgery. The aim was evaluate changes key metabolites potential stratifying patients terms expected...
<h3>Importance</h3> Chinese women have the highest rate of lung cancer among female never-smokers in world, and etiology is poorly understood. <h3>Objective</h3> To assess association between metabolomics risk never-smoking women. <h3>Design, Setting, Participants</h3> This nested case-control study included 275 patients with 289 cancer-free control participants from prospective Shanghai Women's Health Study recruited December 28, 1996, to May 23, 2000. Validated food frequency...
There is increasing interest in the bidirectional relationship existing between gut and brain effects of both oligofructose 2'fucosyllactose to alter microbial composition mood state. Yet, much remains unknown about ability improve state via targeted manipulation microbiota.
The role of the gut microbiome in human health, and non-invasive measurement dysbiosis are increasing clinical interest. New high-throughput methods required for rapid microbial metabolites to establish reference ranges populations. We used ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) -- positive negative electrospray ionization modes, multiple reaction monitoring transitions simultaneously measure three urinary (phenylacetylglutamine, 4-cresyl sulphate...
Colorectal cancer (CRC) is a growing cause of mortality in developing countries, warranting investigation into its etiopathogenesis and earlier diagnosis. Here, we investigated the fecal metabolic phenotype patients with advanced colorectal neoplasia controls using 1H-nuclear magnetic resonance (NMR) spectroscopy multivariate modeling. The microbiota composition was assessed by quantitative real-time PCR as well Wif-1 methylation levels stools, serum, urine correlated to profile each...
Peruvian households have experienced one of the most prevalent economic shocks due to COVID-19, significantly increasing their vulnerability food insecurity (FI). To understand characteristics these among young population, including role government's response through emergency cash transfer, we analysed longitudinal data from Young Lives study (n = 2026), a that follows livelihoods two birth cohorts currently aged 18 27 years old. FI was assessed using Food Insecurity Experience Scale....
Food matrices can be described as the final composition of a food product which results from complex interactions between compounds found within different ingredients and processing parameters used in production. These factors, not only impact on structure product, but also have potential to alter both structural integrity bioavailability potentially beneficial present, for example, dietary fibres. As result, there is growing curiosity amongst scientific community whether matrix may...
Certain bacteria can produce gamma aminobutyric acid (GABA) from glutamate in the human intestinal tract, leading to possibility of altering GABA levels through diet. To this end, we assessed ability seven commercially available probiotic supplements GABA.Probiotic strains were compared for production pure culture. The inoculated at a concentration 107 CFU ml-1 10 ml MRS supplemented with monosodium (1% w/v), both and without oligofructose-enriched inulin (OFI) w/v). Two highest further 48 h...