A5091470446- Eosinophilic Disorders and Syndromes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Diseases and Glomerulopathies
- Genetic factors in colorectal cancer
- Anesthesia and Sedative Agents
- Urologic and reproductive health conditions
- Methemoglobinemia and Tumor Lysis Syndrome
- Inflammasome and immune disorders
- Colorectal Cancer Treatments and Studies
- Systemic Lupus Erythematosus Research
- Digestive system and related health
- Systemic Sclerosis and Related Diseases
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Genetic and Kidney Cyst Diseases
- Viral Infections and Vectors
- Celiac Disease Research and Management
- Organ Transplantation Techniques and Outcomes
- Muscle and Compartmental Disorders
- Skin Diseases and Diabetes
- Inflammatory Myopathies and Dermatomyositis
- Urological Disorders and Treatments
- Vasculitis and related conditions
- Neurological Complications and Syndromes
- IgG4-Related and Inflammatory Diseases
Nottingham University Hospitals NHS Trust
2024
University of Nottingham
2005-2024
University of Arkansas for Medical Sciences
2005-2024
Queen's Medical Centre
2005-2024
Bundelkhand University
2019-2023
Dr. Hari Singh Gour University
2023
University of Florida
2002-2022
Prudential Financial (United States)
2018-2022
Florida College
2020
Islamia College University
2020
In renal Fanconi's syndrome, dysfunction in proximal tubular cells leads to losses of water, electrolytes, and low-molecular-weight nutrients. For most types isolated the genetic cause underlying defect remain unknown.We clinically genetically characterized members a five-generation black family with autosomal dominant syndrome. We performed genomewide linkage analysis, gene sequencing, biochemical cell-biologic investigations cells, studies knockout mice, functional evaluations...
Poor dietary habits and decreased outdoor activity has led to an epidemic of obese children vitamin D deficiency. The lack alters bone development mineralization by diminishing physiological levels calcium phosphorus. Given D's role in growth plate regulation, we hypothesized that deficiency would lead higher rates fractures, slipped capital femoral epiphysis (SCFE), Blount disease youth.A retrospective review was performed at the obesity clinic using database (890 patients). Data obtained...
CDC4/FBXW7 is part of a ubiquitin ligase complex which targets molecules such as cyclin E, c-myc, and c-jun for destruction. CDC4 mutations occur in several cancer types are best described colorectal tumors. Knockout vitro cells causes changes suggestive chromosomal instability (CIN). In p53(+/-) mice, radiation-induced lymphomas show deletion or mutation one copy knockdown leads to increased aneuploidy mouse fibroblasts. We screened 244 tumors 40 cell lines allelic loss. Six percent (18...
In Brief Great attention has been drawn toward the recently defined IgG4 related sclerosing disease, an entity incorporating autoimmune pancreatitis and other organ involvements, hypergammaglobulinemia deposition of in affected tissues. We demonstrate index case this disease with multiple involvements excellent response to corticosteroid treatment. A 69-year-old white man was diagnosed involvement lungs, pancreas, submandibular glands, lymph nodes, kidney. addition, patient had polyclonal...
Introduction: Adherence to the American Academy of Pediatrics clinical practice guidelines for screening and managing high blood pressure (BP) is low. This team sought improve recognition documentation relevant diagnoses in patients aged 13–20 years who presented general pediatric clinics. Methods: The primary outcome measure was proportion office visits ages with a BP ≥ 120/80 visit or problem list diagnosis hypertension elevated BP. Secondary measures included (1) had their measured right...
As mismatch repair status confers differential prognosis in colorectal cancers, this study aimed to determine associations of α-smooth muscle actin (α-SMA) protein expression repair-proficient (pMMR) and repair-deficient (dMMR) tumors with clinicopathologic prognostic features.
Turner syndrome has well-recognized cardiovascular complications that appear in up to 40% of the patients and are more common monosomy X. Left-sided obstructive lesions relatively frequent predispose aortic root dilatation life-threatening dissection. However, bicuspid valves, hypertension, coarctation stenosis also at risk Currently there is no clear guideline regarding best single test for detection or monitoring disease progression.Routine thoracic magnetic resonance imaging (MRI) was...
Objective. To evaluate the effect of a Medical Assessment Unit (MAU) on older patients. Methods. Retrospective case-control study patients 65 years and above admitted to MAU (study group) general medical wards (control in Bankstown-Lidcombe Hospital from 1 October 2008 31 March 2009 with four most common Diagnosis-Related Groups (DRG) (‘falls gait disorder’, ‘chronic obstructive pulmonary disease (COPD)’, ‘other major respiratory diseases ‘cellulitis’). Main outcome measures. Length stay...
We are reporting an infant who was presented to our institution exhibiting a failure thrive and hyponatremia.An extensive renal evaluation revealed resistive hyponatremia with normal glomerular tubular function.Patient remained hyponatremic even after fluid restriction, salt loading Fludrocortisone (Florinef) administration.Water deprivation water tests were suggestive of "hyponatremia reset osmostat".The had no congenital midline defect.
As pathology moves towards digitisation, biomarker profiling through automated image analysis provides potentially objective and time-efficient means of assessment. This study set out to determine how a complex membranous immunostain, E-cadherin, assessed using an digital platform fares in comparison manual evaluation terms clinical correlations prognostication. Tissue microarrays containing 1000 colorectal cancer samples, stained with E-cadherin antibodies were both scoring analysis. Both...