A5056632689- Mesenchymal stem cell research
- Renal function and acid-base balance
- Pluripotent Stem Cells Research
- Bone health and osteoporosis research
- Blood Pressure and Hypertension Studies
- Hospital Admissions and Outcomes
- Vitamin D Research Studies
- Animal Genetics and Reproduction
- Patient Safety and Medication Errors
- Cancer Research and Treatments
- Neuroscience of respiration and sleep
- Nanoplatforms for cancer theranostics
- Diet and metabolism studies
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Muscle Physiology and Disorders
- Dialysis and Renal Disease Management
- Virus-based gene therapy research
- Tissue Engineering and Regenerative Medicine
- Bone health and treatments
- 3D Printing in Biomedical Research
- Neonatal Respiratory Health Research
- Chronic Kidney Disease and Diabetes
- Molecular Biology Techniques and Applications
- Paranormal Experiences and Beliefs
Texas Scottish Rite Hospital for Children
2021-2025
Gyeongsang National University
2021-2025
Minneapolis Heart Institute Foundation
2025
University of Minnesota
2025
Baylor Scott & White Health
2010-2015
American College of Surgeons
2015
October 6 University
2015
Scott & White Memorial Hospital
2011-2014
Temple College
2013
Texas A&M Health Science Center
2012
Current guidelines recommend Na(+)-based alkali for CKD with metabolic acidosis and plasma total CO2 (PTCO2) < 22 mM. Because diets in industrialized societies are typically acid-producing, we compared base-producing fruits vegetables oral NaHCO3 (HCO3) regarding the primary outcome of follow-up estimated GFR (eGFR) secondary outcomes improved reduced urine indices kidney injury.Individuals stage 4 (eGFR, 15-29 ml/min per 1.73 m(2)) due to hypertensive nephropathy, had a PTCO2 level mM, were...
Vitamin D deficiency is an increasingly recognized comorbidity in patients with both type 1 (T1D) and 2 diabetes, particularly associated the presence of diabetic nephropathy.Because we have previously reported enhanced excretion megalin urine T1D microalbuminuria, hypothesized that concurrent urinary loss ligand, vitamin binding protein, might contribute mechanistically to deficiency.Examining a study cohort 115 subjects T1D, aged 14-40 yr, along 55 age-matched healthy control subjects,...
Poor dietary habits and decreased outdoor activity has led to an epidemic of obese children vitamin D deficiency. The lack alters bone development mineralization by diminishing physiological levels calcium phosphorus. Given D's role in growth plate regulation, we hypothesized that deficiency would lead higher rates fractures, slipped capital femoral epiphysis (SCFE), Blount disease youth.A retrospective review was performed at the obesity clinic using database (890 patients). Data obtained...
Proximal femoral varus osteotomy (PFVO) is commonly performed to improve head containment and decrease deformity in Legg-Calve-Perthes disease (LCPD). Little known about how PFVO impacts the quality of life after surgery. The purpose this study was determine longitudinal changes patient-reported physical, mental, social health measures PFVO. This a retrospective review prospectively collected Patient-Reported Outcomes Measurement Information System (PROMIS) data from 20 patients with...
The pig is an important animal model increasingly used for biomedical research, particularly in transplantation strategies involving xenotransplantation or the development of human organs exotransplantation. Pigs, however, are less characterized than other models. In this study, we produced wildtype (WT) embryos via somatic cell nuclear transfer (SCNT) technology and compared them to skeletal muscle null (lacking MYF5/MYOD/MYF6) at embryonic day 41, 62, 90, critical stages porcine...
Abnormal epigenetic reprogramming of nuclear-transferred (NT) embryos leads to the limited efficiency producing cloned animals. Trichostatin A (TSA), a histone deacetylase inhibitor, improves NT embryo development, but its role in acetylation porcine with mesenchymal stem cells (MSCs) is not fully understood. This study aimed compare effects TSA on patterns, and key epigenetic-related genes between vitro fertilization (IVF), NT-MSC, 40 nM TSA-treated NT-MSC (T-NT-MSC). The results...
The differential allocation of medical resources to adult patients according characteristics such as race, gender, and insurance status raises the serious concern that issues apply critically ill children well.This study examined whether outcomes for admitted pediatric intensive care units differed or status.An observational analysis was conducted with use prospectively collected data from a multicenter cohort. Data were on 5,749 consecutive admissions three located in large urban children's...
Rapid activation of a cardiac catheterization laboratory (CCL) has reduced door-to-balloon times in ST-segment elevation myocardial infarction (STEMI), leading to lower mortality. This process is accelerated with prehospital electrocardiography and notification. False activations the CCL occur at an unknown rate have been poorly described.We analyzed 345 consecutive for suspected STEMI over 18 months (March 2009-August 2010). We retrospectively reviewed ECGs that prompted activation, as well...
Human recombinant arginase I cobalt [HuArgI (Co)] coupled with polyethylene glycol 5000 (Co)-PEG5000] has shown potent in-vitro depletion of arginine from tissue culture medium. We now show that HuArgI (Co)-PEG5000 is toxic to almost all cancer cell lines and some normal primary cells examined. In contrast, in combination supplemental L-citrulline selectively cytotoxic a fraction human culture, including melanomas, mesotheliomas, acute myeloid leukemias, hepatocellular carcinomas, pancreas...
The purpose of this study was to determine the incidence rate prostate cancer among men with erectile dysfunction (ED) treated phosphodiesterase type 5 inhibitors (PDE-5i) over a 7-year period vs. ED same age and similar risk factors who were not PDE-5i.In retrospective review electronic medical records billing databases between years 2000 2006, ages 50 69 no history prior identified.These individuals divided into two groups: 2362 had treatment PDE-5i, 2612 did have treatment.Demographic...
Patient handoffs are high-risk times associated with sentinel events. Effective handoff processes may enhance patient safety and team member communication. This study assesses the impact of a standardized protocol for from cardiac surgery operating room to intensive care unit (ICU).Using prospective pre-post design, formalized process was developed including critical elements procedure, script, checklist. Data were collected 60 observations (30 pre 30 post), evaluating 52 unique parameters,...
Mesenchymal stem cells (MSCs) are valuable candidates in tissue engineering and cell-based therapy. Traditionally, MSCs derived from various tissues have been successfully expanded vitro using adherent culture plates commonly called as monolayer two-dimensional (2D) cultures. Recently, many studies demonstrated that stemness multilineage differentiation potential could be enhanced to greater extent when cultured suspended aggregates by means of three-dimensional (3D) culturing techniques....
Mesenchymal stem cells (MSCs) show a decline in pluripotency and differentiation with increased cell culture passages 2D cultures. The monolayer fails to correctly imitate the architecture microenvironments of in-vivo models. Alternatively, 3D may improve simulations wide applications drug discovery. In present study, we compared various culturing techniques such as micro-well (3D-S), hanging drop (HD), ultra-low attachment (ULA) plate-based spheroid study their effect on morphology,...
The actin cytoskeleton plays a crucial role not only in maintaining cell shape and viability but also homing/engraftment properties of mesenchymal stem cells (MSCs), valuable source therapy. Therefore, during the cryopreservation process MSCs, protecting from freezing/thawing stress is critical their functionality therapeutic potential. In this study, safety cryoprotective potential sphingosine-1-phosphate (S1P), which has stabilizing effect on cytoskeleton, dental pulp-derived MSCs...
Chronic ethanol (EtOH) consumption can result in osteopenia. In the current study, we examined modulation of EtOH-induced bone loss during pregnancy. Nonpregnant and pregnant dams were intragastrically infused either control or EtOH-containing diets throughout gestation (gestation d 5 through 20 an equivalent period 15 d) by total enteral nutrition. The effects EtOH (8.5 to 14 g/kg/d) on tibial mineral density (BMD), content (BMC), area assessed at via peripheral quantitative computerized...
Previous studies have shown that mesenchymal stem cells (MSCs) derived from various tissue sources can be differentiated into smooth muscle-like (SMLCs) in vitro. In this paper, dental pulp-derived (DPSCs) were evaluated for their differentiation ability towards under the effect of widely used cytokines (TGF-β1 and PDGF-BB) with special focus on different culturing environments. For purpose, both commercially plates (Norm-c) 0.1% gelatin-precoated (Gel-c) used. Isolated displayed plastic...