A5037433934- Muscle Physiology and Disorders
- Muscle activation and electromyography studies
- Cerebral Palsy and Movement Disorders
- Neuroscience and Neural Engineering
- Tissue Engineering and Regenerative Medicine
- Knee injuries and reconstruction techniques
- Nerve injury and regeneration
- Ion channel regulation and function
- Tendon Structure and Treatment
- Bone fractures and treatments
- Spaceflight effects on biology
- Sports injuries and prevention
- Biomedical Ethics and Regulation
- Effects of Vibration on Health
- Anesthesia and Neurotoxicity Research
- Planarian Biology and Electrostimulation
- Cooperative Studies and Economics
- Musculoskeletal pain and rehabilitation
- Hereditary Neurological Disorders
- Animal Genetics and Reproduction
- Periodontal Regeneration and Treatments
- Connective Tissue Growth Factor Research
- Neurological Disorders and Treatments
- S100 Proteins and Annexins
- Orthopaedic implants and arthroplasty
University of Minnesota
2021-2025
University of Minnesota System
2020-2024
Breakthrough
1992
Abstract Secondary denervation has recently been described as part of the sequela volumetric muscle loss (VML) injury, occurring along with a significantly elevated neurotrophic response, specifically neuregulin‐1 (NRG1). This may contribute to chronic functional impairments associated representing an overlooked treatment target. Thus, though paradoxical, goal this study was pharmacologically reduce signalling after VML using monoclonal antibody (Herceptin) that inhibits ErbB2 receptors. We...
This work advances our understanding of the pathophysiologic complexity volumetric muscle loss injury. Specifically, we identified secondary denervation in remaining after injuries as a novel aspect injury sequela. Denervation increased chronically, parallel with appearance irregular morphological characteristics and destabilization neuromuscular junction, which is expected to further confound chronic functional impairments.
Volumetric muscle loss (VML) is a devastating orthopedic injury resulting in chronic persistent functional deficits, of joint range motion, pathologic fibrotic deposition and lifelong disability. However, there only limited mechanistic understanding VML-induced fibrosis. Herein we examined the temporal changes at 3, 7, 14, 28, 48 days post-VML injury.Adult male Lewis rats (n = 39) underwent full thickness ~20% (~85 mg) VML to tibialis anterior (TA) unilaterally, contralateral TA served as...
The pig is an important animal model increasingly used for biomedical research, particularly in transplantation strategies involving xenotransplantation or the development of human organs exotransplantation. Pigs, however, are less characterized than other models. In this study, we produced wildtype (WT) embryos via somatic cell nuclear transfer (SCNT) technology and compared them to skeletal muscle null (lacking MYF5/MYOD/MYF6) at embryonic day 41, 62, 90, critical stages porcine...
Abstract Volumetric muscle loss (VML) injury occurs when a substantial volume of is lost by surgical removal or trauma, resulting in an irrecoverable deficit function. Recently, it was suggested that VML impacts whole‐body and muscle‐specific metabolism, which might contribute to the inability respond treatments such as physical rehabilitation. The aim this work understand complex relationship between activity response rehabilitation after animal model, evaluating measurement function...
Peripheral nerve-crush injury is a well-established model of neuromuscular junction (NMJ) denervation and subsequent re-innervation. Functionally, the skeletal muscle follows similar pattern as neural recovery, with immediate loss force production that steadily improves in parallel rates On other hand, traumatic to itself, specifically volumetric (VML), results an irrecoverable function. Recent work has indicated significant impairments NMJ following this appear chronic nature, alongside...
This study's objective was to investigate how contractile strength loss associated with a volumetric muscle (VML) injury affects the adjacent tibial bone structural and functional properties in male C57BL/6J mice. Mice were randomized into one of two experimental groups: VML-injured mice that injured at age 12 weeks aged 20 (8 postinjury, VML) 20-week-old age-matched uninjured (Uninjured-20). Tibial strength, mid-diaphysis cortical geometry, intrinsic material properties, metaphyseal...
Following traumatic injury, neuromusculoskeletal tissue undergoes extensive plastic modification. Changes can be observed at the local and systemic levels involve function, signaling, composition. Currently there is limited understanding of early adipogenic changes following some injuries, which needed to understand long-term lack functional muscle recovery. The objective this project was examine plasticity after namely signaling fat droplet deposition volumetric loss (VML) denervation...
Peripheral nerve crush injury is a well-established model of neuromuscular junction (NMJ) denervation and subsequent re-innervation. Functionally, the muscle tissue follows similar pattern as neural recovery, with immediate loss force production that steadily improves in parallel rates On other hand, traumatic to itself, specifically volumetric (VML), results an irrecoverable function. Recent work has indicated significant impairments NMJ following VML appear chronic nature, alongside...
Abstract This study's objective was to investigate the extent which two different levels of low‐intensity vibration training (0.6 g or 1.0 ) affected musculoskeletal structure and function after a volumetric muscle loss (VML) injury in male C57BL/6J mice. All mice received unilateral VML posterior plantar flexors. Mice were randomized into control group (no vibration; VML‐noTX), one experimental groups. The groups for 15‐min/day, 5‐days/week 8 weeks at either 0.6 (VML‐0.6 (VML‐1.0 beginning...
Objective Spasticity in children with cerebral palsy can be managed by a spectrum of approaches, from conservative therapy, to temporary botulinum toxin A injections, permanent transection sensory nerves selective dorsal rhizotomy. This pilot study investigated whether these three tone management approaches are associated histological and biochemical properties the medial gastrocnemius. Design convenience sample undergoing gastrocnemius lengthening surgery was enrolled. Intraoperative...
Skeletal muscles and bones are structurally functionally linked, such that bone strength is primarily determined the frequency magnitude of mechanical strain derived from muscular contractions. Volumetric muscle loss (VML) injury results in a significant tissue non-recoverable strength. However, extent to which limbs sustain VML have associated changes structure functional capacity unknown. This study’s objective was investigate whether affects adjacent tibial adult male C57BL/6J mice. At 12...
Volumetric muscle loss (VML) is a devastating orthopaedic injury that results in chronic persistent functional deficits, of joint range motion, pathologic fibrotic deposition and lifelong disability. Clinically, two major problems exist the care VML injuries: 1) no standard to address function skeletal mass, 2) response impedes healing regeneration, causing destruction architecture altering microenvironment muscle. However, date there only limited mechanistic understanding VML‐induced...
Volumetric muscle loss (VML) is the traumatic of tissue that results in reduced regenerative capacity and long‐term functional deficits. In fact, comparison to mass removed from VML injury, deficits observed are disproportionally greater. Clinically, it estimated nearly 30% injured patients further impacted by some ongoing degree peripheral nerve damage limb. These findings suggest injury has a significant impact on neuromuscular system extends beyond defect area. This supported our recent...