A5048521036- Muscle Physiology and Disorders
- Muscle activation and electromyography studies
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Ion channel regulation and function
- Nerve injury and regeneration
- Neurological Disorders and Treatments
- Pharmacological Effects and Assays
- Cerebral Palsy and Movement Disorders
- Diet and metabolism studies
- Exercise and Physiological Responses
- Cardiovascular and exercise physiology
- Pain Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- S100 Proteins and Annexins
- Cardiac Arrest and Resuscitation
- Planarian Biology and Electrostimulation
- Neuroscience and Neural Engineering
- Tissue Engineering and Regenerative Medicine
- Cardiac Ischemia and Reperfusion
University of Minnesota
2022-2025
University of Minnesota System
2024
North Dakota State University
2023
Abstract Secondary denervation has recently been described as part of the sequela volumetric muscle loss (VML) injury, occurring along with a significantly elevated neurotrophic response, specifically neuregulin‐1 (NRG1). This may contribute to chronic functional impairments associated representing an overlooked treatment target. Thus, though paradoxical, goal this study was pharmacologically reduce signalling after VML using monoclonal antibody (Herceptin) that inhibits ErbB2 receptors. We...
Abstract Volumetric muscle loss (VML) is the traumatic of skeletal muscle, resulting in chronic functional deficits and pathological comorbidities, including altered whole‐body metabolic rate respiratory exchange ratio (RER), despite no change physical activity animal models. In other injury models, treatment with β 2 receptor agonists (e.g. formoterol) improves function. We aimed first to examine if restricting following affects function, second, enhance contractile function remaining VML...
Abstract Volumetric muscle loss (VML) injury results in the unrecoverable of mass and contractility. Oral delivery formoterol, a β2-adrenergic receptor agonist, produces modest recovery contractility VML-injured mice. The objective this study was to determine if regenerative rehabilitation paradigm or medicine could enhance muscle. Regenerative involved oral formoterol combined with voluntary wheel running. direct using non-biodegradable poly(ethylene glycol) biomaterial. To approaches were...
Peripheral nerve-crush injury is a well-established model of neuromuscular junction (NMJ) denervation and subsequent re-innervation. Functionally, the skeletal muscle follows similar pattern as neural recovery, with immediate loss force production that steadily improves in parallel rates On other hand, traumatic to itself, specifically volumetric (VML), results an irrecoverable function. Recent work has indicated significant impairments NMJ following this appear chronic nature, alongside...
Volumetric muscle loss (VML) is associated with persistent functional impairment due to a lack of de novo regeneration. As mechanisms driving the regeneration continue be established, adjunctive pharmaceuticals address pathophysiology remaining may offer partial remediation. Studies were designed evaluate tolerance and efficacy two FDA-approved pharmaceutical modalities tissue after VML injury: (1) nintedanib (an anti-fibrotic) (2) combined formoterol leucine (myogenic promoters). Tolerance...
Mitigation of local pathologic fibrotic tissue deposition is a target area interest for volumetric muscle loss (VML); nintedanib has shown promise reduction fibrosis following VML. Herein studies investigate how in sequence anti-fibrotic treatment administered immediately VML and delayed rehabilitation could improve functional recovery after
Following traumatic injury, neuromusculoskeletal tissue undergoes extensive plastic modification. Changes can be observed at the local and systemic levels involve function, signaling, composition. Currently there is limited understanding of early adipogenic changes following some injuries, which needed to understand long-term lack functional muscle recovery. The objective this project was examine plasticity after namely signaling fat droplet deposition volumetric loss (VML) denervation...
Lillquist, T, Mahoney, SJ, Kotarsky, C, McGrath, R, Jarajapu, Y, Scholten, SD, and Hackney, KJ. The effect of direct remote postexercise ischemic conditioning on muscle soreness strength 24 hours after eccentric drop jumps. J Strength Cond Res 37(9): 1870-1876, 2023-Strategic limb occlusion applied exercise may facilitate recovery, not only in directly targeted tissue but also areas the body. purpose this study was to determine if (PEIC) one leg facilitated recovery contralateral that did...
Abstract Following traumatic musculoskeletal injuries, prolonged bedrest and loss of physical activity may limit muscle plasticity drive metabolic dysfunction. One specific injury, volumetric (VML), results in frank is characterized by whole-body cellular However, how VML restricted the whole-body, cellular, metabolomic environment remaining uninjured remains unclear. Adult mice were randomized to posterior hindlimb compartment or age-matched injury naïve controls, then standard cages for...
Volumetric muscle loss (VML) is the frank of due to injury or surgery and characterized by whole-body cellular metabolic dysfunction. Following VML, prolonged bedrest life-long disability may worsen This work aimed elucidate impact VML physical inactivity on whole-body, cellular, metabolomic environment remaining uninjured muscle. Adult male C57BI/6J mice (n=40) underwent unilateral posterior hindlimb compartment served as age-matched naïve controls, then were randomized standard restricted...
Peripheral nerve crush injury is a well-established model of neuromuscular junction (NMJ) denervation and subsequent re-innervation. Functionally, the muscle tissue follows similar pattern as neural recovery, with immediate loss force production that steadily improves in parallel rates On other hand, traumatic to itself, specifically volumetric (VML), results an irrecoverable function. Recent work has indicated significant impairments NMJ following VML appear chronic nature, alongside...