A5044632325- Body Composition Measurement Techniques
- Sports injuries and prevention
- Sports Performance and Training
- Muscle Physiology and Disorders
- Muscle activation and electromyography studies
- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Cerebral Palsy and Movement Disorders
- Knee injuries and reconstruction techniques
- Exercise and Physiological Responses
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Effects of Exercise
- Adipose Tissue and Metabolism
- Ion channel regulation and function
- Bone fractures and treatments
- Muscle and Compartmental Disorders
- Nerve injury and regeneration
- Coenzyme Q10 studies and effects
- Occupational Health and Performance
- Tendon Structure and Treatment
- Electrical and Bioimpedance Tomography
- Pain Mechanisms and Treatments
- Infrared Thermography in Medicine
- S100 Proteins and Annexins
- Lower Extremity Biomechanics and Pathologies
University of Minnesota
2016-2025
University of Minnesota System
2020-2024
Twin Cities Orthopedics
2016
Committee on Publication Ethics
2016
University of Minnesota Medical Center
2016
Minnesota Department of Education
2016
The body composition phenotype of an athlete displays the complex interaction among genotype, physiological and metabolic demands a sport, diet, physical training. Observational studies dominate literature describe sport-specific physique characteristics (size, shape, composition) adult athletes by gender levels competition. Limited data reveal how measurements can benefit athlete. Thus, objective is to identify purposeful composition, notably fat lean muscle masses, determine their impact...
Abstract Secondary denervation has recently been described as part of the sequela volumetric muscle loss (VML) injury, occurring along with a significantly elevated neurotrophic response, specifically neuregulin‐1 (NRG1). This may contribute to chronic functional impairments associated representing an overlooked treatment target. Thus, though paradoxical, goal this study was pharmacologically reduce signalling after VML using monoclonal antibody (Herceptin) that inhibits ErbB2 receptors. We...
Volumetric muscle loss (VML) is a devastating orthopedic injury resulting in chronic persistent functional deficits, of joint range motion, pathologic fibrotic deposition and lifelong disability. However, there only limited mechanistic understanding VML-induced fibrosis. Herein we examined the temporal changes at 3, 7, 14, 28, 48 days post-VML injury.Adult male Lewis rats (n = 39) underwent full thickness ~20% (~85 mg) VML to tibialis anterior (TA) unilaterally, contralateral TA served as...
Raymond, CJ, Dengel, DR, and Bosch, TA. Total segmental body composition examination in collegiate football players using multifrequency bioelectrical impedance analysis dual X-ray absorptiometry. J Strength Cond Res 32(3): 772-782, 2018-The current study examined the influence of player position on agreement between (MfBIA) absorptiometry (DXA) when assessing total percent fat (BF%), mass (FM), fat-free (FFM) National Collegiate Athletic Association Division I athletes. Forty-four male...
Abstract Volumetric muscle loss (VML) is the traumatic of skeletal muscle, resulting in chronic functional deficits and pathological comorbidities, including altered whole‐body metabolic rate respiratory exchange ratio (RER), despite no change physical activity animal models. In other injury models, treatment with β 2 receptor agonists (e.g. formoterol) improves function. We aimed first to examine if restricting following affects function, second, enhance contractile function remaining VML...
The primary objective of this study was to determine if low- or high-resistance voluntary wheel running leads functional improvements in muscle strength (i.e., isometric and isokinetic torque) metabolic function permeabilized fibre bundle mitochondrial respiration) after a volumetric loss (VML) injury. C57BL/6J mice were randomized into one four experimental groups at age 12 weeks: uninjured control, VML untreated (VML), low-resistance (VML-LR) (VML-HR). All mice, excluding the uninjured,...
Abstract Volumetric muscle loss (VML) injury results in the unrecoverable of mass and contractility. Oral delivery formoterol, a β2-adrenergic receptor agonist, produces modest recovery contractility VML-injured mice. The objective this study was to determine if regenerative rehabilitation paradigm or medicine could enhance muscle. Regenerative involved oral formoterol combined with voluntary wheel running. direct using non-biodegradable poly(ethylene glycol) biomaterial. To approaches were...
Age-related functional declines are thought to be caused by hallmark biological processes that manifest in physical, mental, and metabolic impairments compromising intrinsic capacity, healthspan quality-of-life. Exercise is a multipotent treatment with promise mitigate most aging hallmarks, but there substantial variability individual exercise responsiveness. This inter-individual response heterogeneity (IRH) was first extensively interrogated Bouchard colleagues the context of endurance...
Abstract Volumetric muscle loss (VML) injury occurs when a substantial volume of is lost by surgical removal or trauma, resulting in an irrecoverable deficit function. Recently, it was suggested that VML impacts whole‐body and muscle‐specific metabolism, which might contribute to the inability respond treatments such as physical rehabilitation. The aim this work understand complex relationship between activity response rehabilitation after animal model, evaluating measurement function...
Abstract This study aimed to examine body composition using dual X-ray absorptiometry (DXA) in male and female NCAA Division I collegiate basketball athletes. Two-hundred ten (male [M]/female [F]=88/122) athletes’ total regional fat mass, lean bone mineral density, visceral adipose tissue were measured. Athletes classified as: point guards (M/F=27/34), shooting (M/F=18/27), small forwards (M/F=13/18), power (M/F=21/27), centers (M/F=9/16). ANOVA Tukey’s HSD assessed positional differences by...
Volumetric muscle loss (VML) injuries result in a non-recoverable of tissue and function due to trauma or surgery. Reductions physical activity increase the risk metabolic comorbidities over time, it is likely that VML may reduce whole-body activity. However, these aspects remain uncharacterized following injury. Our goal was characterize impact on metabolism, further investigate possible muscle-specific changes. Adult male C57Bl/6J (n = 28) mice underwent standardized injury posterior...
The purpose of this study was to evaluate total, regional, and throwing versus non-throwing arm body composition measures across the 4 major positions NCAA Division I female softball players using dual X-ray absorptiometry (DXA) (n=128). Total regional total mass (TM), fat (FM), lean (LM), bone mineral density (BMD), content (BMC), visceral adipose tissue were measured. Athletes separated into: pitchers (n=32), catchers (n=13), outfielders (n=39), infielders (n=44). ANOVA Tukey's HSD...
Peripheral nerve-crush injury is a well-established model of neuromuscular junction (NMJ) denervation and subsequent re-innervation. Functionally, the skeletal muscle follows similar pattern as neural recovery, with immediate loss force production that steadily improves in parallel rates On other hand, traumatic to itself, specifically volumetric (VML), results an irrecoverable function. Recent work has indicated significant impairments NMJ following this appear chronic nature, alongside...
Abstract Raymond-Pope, CJ, Dengel, DR, Fitzgerald, JS, and Bosch, TA. Association of compartmental leg lean mass measured by dual X-ray absorptiometry with force production. J Strength Cond Res 34(6): 1690–1699, 2020—We recently reported a novel method for measuring upper anterior/posterior composition. The purpose this study was to determine the association measures muscle-specific explosive strength compare traditional energy (DXA) measurements total masses. We hypothesize will be related...
This study's purpose was to evaluate total, regional, and throwing versus non-throwing arm body composition measurements between various positions of NCAA Division I male baseball players using dual X-ray absorptiometry (DXA). Two hundred one collegiate athletes were measured DXA. Visceral adipose tissue (VAT), total regional fat mass (FM), lean (LM), bone mineral density (BMD) measured. Athletes separated into: pitchers (n=92), catchers (n=25), outfielders (n=43), infielders (n=41). ANOVA...
Volumetric muscle loss (VML) is associated with persistent functional impairment due to a lack of de novo regeneration. As mechanisms driving the regeneration continue be established, adjunctive pharmaceuticals address pathophysiology remaining may offer partial remediation. Studies were designed evaluate tolerance and efficacy two FDA-approved pharmaceutical modalities tissue after VML injury: (1) nintedanib (an anti-fibrotic) (2) combined formoterol leucine (myogenic promoters). Tolerance...
This study aimed to investigate the accuracy and reliability of a novel dual-energy x-ray absorptiometry (DXA) scanning method in frontal plane for total, fat, lean mass quantification anterior posterior upper leg compartments.Twenty-one (11 females; X¯age = 20.3 ± 1.3 yr) college athletes were assessed total regional body composition using DXA. The segmentation anterior/posterior thigh compartments was measured with participants lying on their right left sides scanned elevated two foam...
Mitigation of local pathologic fibrotic tissue deposition is a target area interest for volumetric muscle loss (VML); nintedanib has shown promise reduction fibrosis following VML. Herein studies investigate how in sequence anti-fibrotic treatment administered immediately VML and delayed rehabilitation could improve functional recovery after
Abstract Objectives To compare total and regional body fat percent (BF%) measurements obtained using a handheld electrical impedance myography (EIM) device in comparison to BF% measured by dual X‐ray absorptiometry (DXA). Methods Sixty‐nine male female (33 males/36 females; age = 21.9 ± 2.0 years, mass index 24.5 3.6 kg/m 2 ) college‐age individuals participated this study. Each participant's (ie, upper arms, legs, trunk) was estimated EIM DXA. Metallic markers were used delineate boundaries...
To examine measures of total and regional body composition using dual X-ray absorptiometry (DXA) in NCAA Division I collegiate equestrian athletes, 31 female athletes were matched to a population normal controls by age mass index. Total fat tissue (FM), lean (LM), bone mineral density (BMD), abdominal visceral adipose (VAT) measured DXA. Equestrian had significantly (p=0.03) lower percentage (%fat) than controls. There no significant differences LM VAT between However, when compared the...
Abstract We sought to examine the relationship between upper-leg compartmental lean mass, muscle-specific strength, and explosive strength following anterior cruciate ligament reconstruction. Twleve adolescent female athletes with prior reconstruction were individually-matched by age (16.4±0.9 vs. 16.4±1.0 yrs.), body mass index (23.2±2.1 23.2±2.7 kg/m2), sport 12 athlete controls. One total-body 2 lateral-leg dual X-ray absorptiometry scans measured total/segmental composition. Isokinetic...
Following traumatic injury, neuromusculoskeletal tissue undergoes extensive plastic modification. Changes can be observed at the local and systemic levels involve function, signaling, composition. Currently there is limited understanding of early adipogenic changes following some injuries, which needed to understand long-term lack functional muscle recovery. The objective this project was examine plasticity after namely signaling fat droplet deposition volumetric loss (VML) denervation...
Volumetric muscle loss (VML) injuries are a traumatic of muscle, limiting regenerative potential and resulting in chronic function. In isolation the bone adjacent to VML injury is often overlooked, but known association between tissues important long-term health Recent work suggests decrements both bones muscles VML-injured limbs, as well distinct relationship health. The clinically injured population expected undergo considerable periods physical inactivity or sedentary lifestyle, thus...