A5083467892- Advanced MRI Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Hip disorders and treatments
- Lower Extremity Biomechanics and Pathologies
- Bone and Joint Diseases
- Bipolar Disorder and Treatment
- MRI in cancer diagnosis
- Spine and Intervertebral Disc Pathology
- Organ Transplantation Techniques and Outcomes
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Shoulder Injury and Treatment
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Musculoskeletal pain and rehabilitation
- Electron Spin Resonance Studies
- Lanthanide and Transition Metal Complexes
- Autopsy Techniques and Outcomes
- Cardiac Imaging and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Orthopaedic implants and arthroplasty
- Atomic and Subatomic Physics Research
- Medical Imaging Techniques and Applications
- Bone fractures and treatments
- Cerebrovascular and Carotid Artery Diseases
University of Minnesota
2016-2025
Resonance Research (United States)
2015-2024
John Wiley & Sons (United States)
2019-2023
University of Iowa
2013-2021
Southwestern Medical Center
2018
The University of Texas Southwestern Medical Center
2018
Scottish Rite Hospital
2018
Roswell Park Comprehensive Cancer Center
2017
Steadman Philippon Research Institute
2016
Steadman Clinic
2016
In a group of patients with high-grade asymptomatic carotid artery stenosis, we prospectively determined the prevalence and radiological characteristics clinically brain infarction evident on computed tomography. Risk factors extent disease were also determined. Patients randomized into Asymptomatic Carotid Atherosclerosis Study (ACAS) underwent neurological history, detailed stroke/transient ischemic attack questionnaire, examination. Computed tomography scans examined by standardized...
Purpose To introduce a blind compressed sensing (BCS) framework to accelerate multi‐parameter MR mapping, and demonstrate its feasibility in high‐resolution, whole‐brain T 2 mapping. Methods BCS models the evolution of magnetization at every pixel as sparse linear combination bases dictionary. Unlike sensing, dictionary coefficients are jointly estimated from undersampled data. Large number non‐orthogonal accounts for more complex signals than low rank representations. The degree freedom...
Purpose To retrospectively determine if a modified clinical magnetic resonance (MR) imaging protocol provides information on the origin of juvenile osteochondritis dissecans (JOCD) lesions and allows for staging basis proposed natural history JOCD to better guide management disease. Materials Methods This institutional review board-approved, HIPAA-compliant, retrospective study was performed in 13 consecutive patients (mean age, 14.9 years; age range, 10-22 nine male four female patients)...
To provide an illustrated, detailed semiquantitative analysis of the important degenerative changes along length vertebral artery so that pathologists faced with investigating a fatal arterial injury can identify pre-existing wall abnormalities.Ten transverse annuli were taken 34 arteries from 17 subjects and stained sections prepared using haematoxylin eosin picro-sirius red method. After routine microscopy, elastic fibres, collagen, smooth muscle nuclei in tunica media quantified eyepiece...
Objectives Quantitative mapping of T1 relaxation in the rotating frame (T1ρ) is a magnetic resonance imaging technique sensitive to pH and other cellular microstructural factors, potentially valuable tool for identifying brain alterations bipolar disorder. Recently, this identified differences cerebellum cerebral white matter euthymic patients vs healthy controls that were consistent with reduced these regions, suggesting an underlying metabolic abnormality. The current study built upon...
The pig is an important animal model increasingly used for biomedical research, particularly in transplantation strategies involving xenotransplantation or the development of human organs exotransplantation. Pigs, however, are less characterized than other models. In this study, we produced wildtype (WT) embryos via somatic cell nuclear transfer (SCNT) technology and compared them to skeletal muscle null (lacking MYF5/MYOD/MYF6) at embryonic day 41, 62, 90, critical stages porcine...
Toll-like receptor 5 (TLR5) is considered an attractive target for anticancer immunotherapy. TLR5 agonists, bacterial flagellin and engineered derivatives, have been shown to potent antitumor metastasis-suppressive effects in multiple animal models be safe both animals humans. Anticancer efficacy of agonists stems from TLR5-dependent activation nuclear factor-κB (NF-κB) that mediates innate adaptive immune responses. To extend application TLR5-targeted immunotherapy tumors do not naturally...
The genotype with respect to the point mutation at position 1843 of ryr-1 gene (halothane gene) and longissimus muscle quality 1006 pigs in two Western Canadian packing plants was assessed determine frequency this within commercial population relationship PSE (pale, soft, exudative) pork. frequencies nn (homozygous carrier), Nn (heterozygous carrier) NN normal) were 0.3, 9.4 90.3%, respectively. Based on subjective pork standards Agriculture Agri-Food Canada, paler-than-normal (colour score...
Purpose To use quantitative susceptibility mapping (QSM) to investigate changes in cartilage canals the distal femur of juvenile goats after their surgical transection. Methods Chondronecrosis was surgically induced right medial femoral condyles four 4‐day‐old goats. Both operated and control knees were harvested at 2, 3, 5, 10 weeks surgeries. Ex vivo MRI scans conducted 9.4 Tesla using T RAFF (relaxation time along a fictitious field)‐weighted fast spin echo imaging QSM detect areas...
The authors determine if any aspects of the treatment renal transplant patients with pancreatitis were particular benefit regard to graft and patient survival.The incidence in is low (1%-2%), but mortality disease approaches 100%. Although several descriptive reports have been published, there no consensus-regarding management.The conduct a retrospective chart review.Twenty-one identified posttransplant (1.3% incidence). cause was presumed be maintenance immunosuppression all cases. Patients...
Abstract Background Imaging biomarkers sensitive to Huntington's disease (HD) during the premanifest phase preceding motor diagnosis may accelerate identification and evaluation of potential therapies. For this purpose, quantitative MRI tissue microstructure metabolism hold great potential. We investigated value T1ρ relaxation detect pathological changes in HD (preHD) relative other parameters. Methods Quantitative MR parametric mapping was used assess differences between 50 preHD subjects...
To describe, assess, and implement a simple precision estimation framework for optimization of spin-lock time (TSL) sampling schedules quantitative T1ρ mapping using mono-exponential signal model.A method is described estimating precision, cost function based on the estimates evaluated to determine efficient TSL schedules. The validity was tested by imaging phantom with various comparing theoretical experimental values. utility demonstrated in vivo brain tissue similar procedure as...
Purpose To evaluate multiple MRI parameters in a surgical model of osteochondrosis (OC) goats. Methods Focal ischemic lesions two different sizes were induced the epiphyseal cartilage medial femoral condyles goats at 4 days age by transection canal blood vessels. Goats euthanized and specimens harvested 3, 4, 5, 6, 9 10 weeks post-op. Ex vivo scans conducted 9.4 Tesla for mapping T1, T2, T1ρ, adiabatic T1ρ TRAFF relaxation times articular cartilage, unaffected within area lesion. After...
Low-frequency ultradian and high-frequency insulin secretion pulses were studied in normal subjects metabolically stable pancreas transplant recipients. Insulin pulsatility was evaluated after deconvoluting the pulsatile plasma C peptide concentrations with its kinetic coefficients. In subjects, periodicities of 75-115 min consistently observed during 24-h secretory cycle. Pulse period relative amplitude overnight rest (95 +/- 4 27.6 2.4%) similar to those steady state continuous enteral...
malignancies (six in 1989 and 20 1990) that many of these are not suspected to be malignant before excision.Controversy exists about whether general practitioners should remove lesions.Paver suggests if the diagnosis is uncertain, there a facial lesion, or melanoma patient referred consultant.'However, long waiting times for consultant appoint- ments strong argument family doctors doing surgery as early excision skin malignancy more likely cure.Whether removing lesions it imperative who wish...
Background Legg‐Calvé‐Perthes disease (LCPD) is a childhood hip disorder thought to be caused by disruption of blood supply the developing femoral head. There potential for imaging help assess revascularization Purpose To investigate whether quantitative susceptibility mapping (QSM) can detect neovascularization in epiphyseal cartilage following ischemic injury Study Type Prospective. Animal Model Right head ischemia was surgically induced 6‐week‐old male piglets. The animals were sacrificed...