A5101701362- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Neurotransmitter Receptor Influence on Behavior
- Ophthalmology and Eye Disorders
- Ear Surgery and Otitis Media
- Noise Effects and Management
- Neural and Behavioral Psychology Studies
- Cell death mechanisms and regulation
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Ubiquitin and proteasome pathways
- Chronic Lymphocytic Leukemia Research
- Ergonomics and Musculoskeletal Disorders
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Research in Cotton Cultivation
- Bioactive Compounds and Antitumor Agents
- Infrared Thermography in Medicine
- Speech and Audio Processing
- Behavioral Health and Interventions
- Obstructive Sleep Apnea Research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
Zhejiang Normal University
2020-2025
XinHua Hospital
2015-2025
Shanghai Jiao Tong University
2013-2025
First Affiliated Hospital of Jiangxi Medical College
2025
Jiangxi Provincial People's Hospital
2025
Changsha University of Science and Technology
2024-2025
Hubei University of Chinese Medicine
2022
Zhejiang University
2014-2017
Qingdao Eighth People's Hospital
2016
Ningbo No.6 Hospital
2015
We have designed MI-219 as a potent, highly selective and orally active small-molecule inhibitor of the MDM2–p53 interaction. binds to human MDM2 with K i value 5 nM is 10,000-fold for over MDMX. It disrupts interaction activates p53 pathway in cells wild-type p53, which leads induction cell cycle arrest all apoptosis tumor cells. stimulates rapid but transient activation established xenograft tissues, resulting inhibition proliferation, apoptosis, complete growth inhibition. normal tissues...
Microtubule-disrupting agents such as the taxanes comprise some of most clinically useful chemotherapeutic and invoke spindle checkpoint in proliferating cells. A robust turn may forestall mitotic catastrophe, potentially providing a mechanism that permits cancer cells to survive transient exposure these drugs. Previous reports on G2-M cell cycle progression by histone deacetylase inhibitors suggested potential role modulating therapeutic efficacy microtubule-disrupting agents. As both...
To compared the incidence rates and clinical features of precocious girls before during COVID-19 pandemic among Shanghai school-aged girls, explored potential mechanisms.This cross-sectional study collected medical data about between 2016 2020 from Children's Medical Center. Data inpatient March to August in 2016-2019 (n=246) (n=237) were collected. Subjects with abnormal brain pituitary gland MRI reports, other endocrine diseases or chronic excluded. Finally, 209 included group 191 include...
Abstract Overexpression of Bcl-2/Bcl-XL protein has been observed in more than 80% B-cell lymphomas. Diffuse large cell lymphoma (DLCL) is the most common subtype non-Hodgkin's lymphoma. (−)-Gossypol, a natural product isolated from cottonseeds, was discovered as potent small-molecule inhibitor Bcl-2 and Bcl-XL proteins, with Ki value nanomole per liter range for both. In vitro, (−)-gossypol showed significant growth inhibition effect against WSU-DLCL2 line fresh cells obtained patient no on...
We report herein the structure-based design of a class conformationally constrained, potent, cell-permeable small-molecule inhibitors to target SH2 domain in STAT3. Compound 11 (CJ-1383) binds STAT3 with K(i) value 0.95 µM, dose-dependently inhibits cellular signaling and cancer cell growth, induces apoptosis MDA-MB-468 line constitutively activated
Abstract Myelin undergoes various changes after nerve injury, and c‐Jun has a close relationship with Schwann cells (SCs). However, it remains unclear whether can be involved in repair by regulating ferroptosis. To explore this, we first set up facial injury model detected the of ferroptosis‐related proteins immunofluorescence Western blot. Then, cultured RSC 96 pSCs, studied potential regulatory relationships combination experimental methods such as CCK‐8, ELISA, immunofluorescence,...
Abstract Elevated expression of anti-apoptotic Bcl-2 family proteins have been linked to a poor survival rate patients with Follicular Lymphoma (FL). This prompted us evaluate very potent non-peptidic Small-Molecule Inhibitor (SMI) targeting proteins, Apogossypolone (ApoG2) using follicular small cleaved cell lymphoma line (WSU-FSCCL) and isolated from patients. ApoG2 inhibited the growth WSU-FSCCL significantly 50% inhibition cells (IC 50 ) 109 nM decreased number fresh cells. activated...
Objective To investigate the associations between cognition, anxiety, depression, and residual dizziness after successful repositioning maneuvers in elderly with benign paroxysmal positional vertigo (BPPV). Methods We enrolled 40 patients BPPV our outpatient department. used Dizziness Handicap Inventory (DHI), Visual Analog Scale (VAS), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder Questionnaire-7 (GAD-7) to assess degree of dizziness, depression participants before...
Background While the constitutive features of problematic social media use (PSMU) have been formulated, there has a lack studies in field examining structure relationships among PSMU components. Method This study employed network analytic methods to investigate connectivity components large sample 1,136 college student users ( M age = 19.69, SD 1.60). Components were assessed by Bergen Social Media Addiction Scale (BSMAS) derived from model addiction. We computed two types models, Gaussian...
Background Following successful canalith repositioning procedures (CRPs), some patients with benign paroxysmal positional vertigo (BPPV) may experience residual symptoms. There is currently no consensus on whether these symptoms are related to the disease duration. Objective To examine impact of BPPV duration persistence following CRP. Methods A total 102 idiopathic were enrolled and categorized into short-course long-course groups based disease. The course in group was less than or equal 7...
BACKGROUND Transjugular intrahepatic portosystemic shunt (TIPS) has an important role in the therapy of complications portal-hypertension-related ascites. Various guidelines now indicate that TIPS is indicated for refractory ascites (RA), but recurrent nonrefractory (RNRA) achieved better clinical results. AIM To compare outcomes RA and RNRA patients with related to portal hypertension. METHODS There were 863 divided into two main categories who underwent between September 2016 2021. In...
Liver cirrhosis patients can develop various complications including bacteremia as the intestinal flora is heterologous. In those with low immunity, trauma, or following surgery, etc., body susceptible to concurrent systemic local infections. Under these circumstances, even minimally invasive treatment methods such interventional therapy like transjugular intrahepatic portosystemic shunt (TIPS) for liver also result in A male patient decompensated experienced multiple episodes of...
Abstract Background: Overexpression of antiapoptotic proteins, such as cellular inhibitor apoptosis proteins 1 (cIAP1) and 2 (cIAP2) X-linked IAP (XIAP), occurs in various hematologic solid cancers is associated with drug resistance poor prognosis. Several small molecules are being investigated clinically monotherapy or combination therapy tumors. AS03157, a novel structurally distinct antagonist, was identified enhanced specificity towards cIAP1 XIAP, its pharmacological profiles were...
Apogossypolone (ApoG2) is a semi-synthesized derivative of gossypol. The principal objective this study was to compare stability and toxicity between ApoG2 gossypol, evaluate anti-lymphoma activity in vitro vivo. shows better when compared with racemic gossypol can be tolerated by mice showed significant inhibition cell proliferation WSU-DLCL(2) primary cells obtained from lymphoma patients, whereas it displayed no on normal peripheral blood lymphocytes. For treatment 72 h, the IC(50)...
Objectives Universal neonatal hearing screening (UNHS) started late in some underdeveloped areas China, with relatively scarce resources and a wide regional distribution. This study aimed to compare the performance between rural urban populations, examine characteristics problems of UNHS regions China. Methods A two-step program was used neonates born Liuzhou Maternal Child Health Hospital patients who were other hospitals, but admitted intensive care unit. involved distortion product...
Abstract Tinnitus is associated with neural hyperactivity in the central nervous system (CNS). Salicylate a well-known ototoxic drug, and we induced tinnitus rats using model of long-term salicylate administration. The gap pre-pulse inhibition acoustic startle test was used to infer perception, only chronic salicylate-treatment (14 days) group showed evidence experiencing tinnitus. After small animal positron emission tomography scans were performed, found that metabolic activity inferior...
Mutations in the GJB2 gene that encodes connexin 26 (Cx26) are predominant cause of prelingual hereditary deafness, and most frequently encountered variants complete loss protein function. To investigate how Cx26 deficiency induces we examined levels apoptosis autophagy Gjb2 loxP/loxP ; ROSA26 CreER mice injected with tamoxifen on day birth. After weaning, these exhibited severe hearing impairment reduced expression cochlear duct. Terminal deoxynucleotidyl transferase dUTP nick end labeling...