A5100763359- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Electron Spin Resonance Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal-Organic Frameworks: Synthesis and Applications
- Ear Surgery and Otitis Media
- Noise Effects and Management
- Molecular Sensors and Ion Detection
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Plant Molecular Biology Research
- Biochemical Analysis and Sensing Techniques
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Gas Sensing Nanomaterials and Sensors
- Ion Channels and Receptors
- Electromagnetic wave absorption materials
- RNA regulation and disease
- Advanced Chemical Sensor Technologies
- Silk-based biomaterials and applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Polydiacetylene-based materials and applications
- Curcumin's Biomedical Applications
Henan Polytechnic University
2023-2025
Inner Mongolia University
2020-2024
Guizhou Normal University
2024
Shanghai Jiao Tong University
2009-2023
Shanghai University of Traditional Chinese Medicine
2023
Shanghai Ninth People's Hospital
2017-2023
Wuhan University of Science and Technology
2023
Yueyang Hospital
2023
Shandong Agricultural University
2022
State Forestry and Grassland Administration
2022
Abstract Rational design of high-performance stable metal–organic framework (MOF) membranes is challenging, especially for the sustainable treatment hypersaline waters to address critical global environmental issues. Herein, a molecular-level intra-crystalline defect strategy combined with selective layer thinning protocol proposed fabricate robust ultrathin missing-linker UiO-66 (ML-UiO-66) membrane enable fast water permeation. Besides almost complete salt rejection, high and flux achieved...
Clarifying the relationship between soil microorganisms and plant-soil system is crucial for encouraging sustainable development of ecosystems, as serve a variety functional roles in system. In this work, influence mechanisms significant microbial groups on their applications environmental remediation over previous 30 years were reviewed using systematic literature review (SLR) methodology. The findings demonstrated that: (1) There has been general upward trend number publications...
Due to the disruption by other nonanalyte factors, single-emission probes have been limited in complicated detecting systems. In this work, a pH-modulated luminescence chameleon system based on lanthanide-based MOF (Eu3+@Mn-MOF), with stable structure and miraculous dual-emitting fluorescent properties, was synthesized postsynthetic modification (PSM) strategy of simple hydrothermal agitation method. Amazingly, not only can Eu3+@Mn-MOF emit broad emission at 500 nm attributed ligand-based...
Abstract: This study aimed to investigate the sustained drug release properties and hearing protection effect of polyethylene glycol-coated polylactic acid (PEG-PLA) stealth nanoparticles loaded with dexamethasone (DEX). DEX was fabricated into PEG-PLA using an emulsion evaporation technique, as previously reported. The DEX-loaded (DEX-NPs) had a hydrodynamic diameter 130±4.78 nm, zeta potential -26.13±3.28 mV. in vitro from DEX-NPs lasted 24 days phosphate buffered saline (pH 7.4), 5...
Excessive accumulation of reactive oxygen species (ROS) has been documented as the crucial cellular mechanism cisplatin-induced ototoxicity. However, numerous antioxidants have failed in clinical studies partly due to inefficient drug delivery cochlea. A system is an attractive strategy overcome this drawback.In present study, we proposed combination antioxidant astaxanthin (ATX) and ROS-responsive/consuming nanoparticles (PPS-NP) combat ATX-PPS-NP were constructed by self-assembly...
Recently, the detection of acetone by using a gas sensor fabricated with metal oxide semiconductors has stimulated intense research enthusiasm, owing to its promising application in noninvasive diagnosis diabetes monitoring human exhaled breath. In this work, potential was comodification nanosheets-assembled ZnCo2O4 hierarchical microspheres (HMSs) MoO3 and Ag nanoparticles (NPs). The HMSs were synthesized via solvothermal route then sequentially modified NPs immersion, calcination,...
The delivery of treatment agents to inner ear with drug system (DDS) has been under investigation overcome the limitations conventional therapeutic in curing or alleviating cisplatin ototoxicity.In present study, a novel targeted dexamethasone (DEX)-loaded DDS, A666-DEX-NP, was constructed for prevention from cisplatin-induced hearing loss. A666-(CLEPRWGFGWWLH) peptides specifically bind prestin, which is limited outer hair cells (OHCs). HEI-OC1 and cisplatin-treated guinea pigs (12 mg/kg,...
Background: Cisplatin is an extensively used anti-neoplastic agent for the treatment of various solid tumors. However, a high incidence severe ototoxicity accompanied by its use in clinic. Currently, no drugs or therapeutic strategies have been approved cisplatin-induced FDA. Purpose: The purpose this study was to investigate otoprotective effects dexamethasone (DEX)-loaded silk-polyethylene hydrogel (DEX-SILK) following round window membrane administration mouse model. Methods: morphology,...
Nitroalkene derivative of oleic acid (OA-NO2), due to its ability mediate revisable Michael addition, has been demonstrated have various biological properties and become a therapeutic agent in diseases. Though antioxidant reported different models acute kidney injury (AKI), the mechanism by which OA-NO2 attenuates intracellular oxidative stress is not well investigated. Here, we elucidated anti-oxidative an vitro model renal ischemia/reperfusion (I/R) injury. Human tubular epithelial cells...
Abstract Background Ototoxicity is one of the major side effects platinum-based chemotherapy, especially cisplatin therapy. To date, no FDA approved agents to alleviate or prevent this ototoxicity are available. However, generally believed be produced by excessive generation reactive oxygen species (ROS) in inner ear, thus leading development various antioxidants, which act as otoprotective agents. Astaxanthin (ATX) an interesting candidate new therapies for preventing and treating oxidative...
Conductive metal–organic frameworks (cMOFs), which have high porosity and intrinsic electron conductivity, are regarded as ideal candidates for electromagnetic wave (EMW) absorption materials. Controlling the nanostructure of absorbers may be one effective strategies to improve performance. Herein, a series conductive Cu-HHTP MOFs (HHTP = 2,3,6,7,10,11-hexahydroxytriphenyl hydrates) with different nanostructures or crystal morphologies were successfully synthesized by using structural...
Objectives Universal neonatal hearing screening (UNHS) started late in some underdeveloped areas China, with relatively scarce resources and a wide regional distribution. This study aimed to compare the performance between rural urban populations, examine characteristics problems of UNHS regions China. Methods A two-step program was used neonates born Liuzhou Maternal Child Health Hospital patients who were other hospitals, but admitted intensive care unit. involved distortion product...
The study of drug delivery systems to the inner ear is a crucial but challenging field. sensory organ (in ear) protected by petrous bone labyrinth and membranous labyrinth, both which need be overcome during process. requirements for such system include small size, appropriate flexibility biodegradability. DNA nanostructures, biomaterials that can arrange multiple functional components with nanometer precision, exhibit characteristics are compatible delivery. Herein, we report development...
Abstract Tinnitus is associated with neural hyperactivity in the central nervous system (CNS). Salicylate a well-known ototoxic drug, and we induced tinnitus rats using model of long-term salicylate administration. The gap pre-pulse inhibition acoustic startle test was used to infer perception, only chronic salicylate-treatment (14 days) group showed evidence experiencing tinnitus. After small animal positron emission tomography scans were performed, found that metabolic activity inferior...