A5100412484- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Synthesis and biological activity
- Carbon dioxide utilization in catalysis
- Synthesis and Catalytic Reactions
- Cyclopropane Reaction Mechanisms
- Catalysis for Biomass Conversion
- Fluorine in Organic Chemistry
- Crystal structures of chemical compounds
- Advanced Synthetic Organic Chemistry
- Supercapacitor Materials and Fabrication
- Synthesis and Characterization of Heterocyclic Compounds
- Catalytic Cross-Coupling Reactions
- Synthesis and Biological Evaluation
- Biodiesel Production and Applications
- Synthesis of Indole Derivatives
- Microbial Natural Products and Biosynthesis
- Organic Chemistry Cycloaddition Reactions
- Atrial Fibrillation Management and Outcomes
- Cloud Computing and Remote Desktop Technologies
- Quinazolinone synthesis and applications
- Phytochemistry and Bioactivity Studies
Peking University
2009-2024
Peking University People's Hospital
2024
Taiyuan University of Technology
2021-2023
Tsinghua University
2013-2018
Jilin Engineering Normal University
2017
Ludong University
2016
Second Hospital of Shandong University
2016
Changzhou University
2014
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2013
Center for Life Sciences
2013
A new and straightforward method to construct 1H-benzo[d]imidazole was developed by means of PdII-catalyzed intramolecular CH activation starting from easily available N-phenylbenzimidamide (see scheme). The detailed mechanism studies indicated that a palladacycle monomer or dimer is the key intermediate for this transformation thiourea used first time promote efficiency activation. Detailed facts importance specialist readers are published as "Supporting Information". Such documents...
Convergent approach: The total syntheses of (−)-flueggine A and (+)-virosaine B (see scheme) have been accomplished in a concise convergent manner. Key steps these approaches were relay ring-closing metathesis reactions for rapid construction the key intermediates, 1,3-dipolar cycloaddition formation natural products.
An improved, tandem acid activation/aldol-lactonization process is described. This more practical protocol shortens reaction times for the construction of bicyclic β-lactones from ketoacids and implements use commercially available reagents p-toluenesulfonyl chloride (p-TsCl) as activator 4-dimethylaminopyridine (4-DMAP) nucleophilic promoter (Lewis base). Substrates with β-substituents, respect to carboxylic acid, consistently showed excellent levels diastereoselectivity during...
Abstract The first total syntheses of asperchalasines A–E, a collection unprecedented merocytochalasans, are reported. Aspochalasin B, key tricyclic cytochalasan monomer, was synthesized through unified approach that hinges on Diels–Alder reaction and ring‐closing metathesis reaction. bioinspired reactions aspochalasin B with different epicoccine precursors were then explored, which enabled the divergent access heterodimers B–E as well related congeners. Furthermore, heterotrimer...
Nitroalkene derivative of oleic acid (OA-NO2), due to its ability mediate revisable Michael addition, has been demonstrated have various biological properties and become a therapeutic agent in diseases. Though antioxidant reported different models acute kidney injury (AKI), the mechanism by which OA-NO2 attenuates intracellular oxidative stress is not well investigated. Here, we elucidated anti-oxidative an vitro model renal ischemia/reperfusion (I/R) injury. Human tubular epithelial cells...
The concise total synthesis of aplykurodinone-1 with an unusual cis-fused hydrindane moiety has been accomplished without the need for any protecting group chemistry using a unique SmI2 mediated reductive cascade cyclization reaction and direct cuprate 1,4-addition. This work represents first example use SmI2-mediated intramolecular between "halide, alkene aldehyde" groups.
Eine glatte Umwandlung von(R)-Carvon in ein β-Lacton und dann (+)-Omphadiol kennzeichnet die erste Totalsynthese dieses Sesquiterpens 10 Stufen 18 % Gesamtausbeute. Alle sechs benachbarten Stereozentren wurden hoch diastereoselektiv eingeführt. Schlüsselschritte waren eine Nucleophil-vermittelte Aldollactonisierung, sequenzielle intra-/intermolekulare Eintopfdialkylierung, Tandem-Olefinisomerisierung/RCM Cyclopropanierung mit ungewöhnlicher Seitenselektivität.
CO2 carboxylation is an important and attractive way of resourceful utilization, which could synthesize carboxylic acids. As the most promising alternative to terephthalic acid, 2,5-furandicarboxylic acid (FDCA) be produced by direct biomass-derived 2-furoic (FA) promoted Cs2CO3, but high cost cesium limits development route. Herein, low-cost K2CO3 was only used promote FA for synthesis FDCA, whose feasibility demonstrated theoretical calculations experiments. However, reaction system...
Abstract The first total syntheses of asperchalasines A–E, a collection unprecedented merocytochalasans, are reported. Aspochalasin B, key tricyclic cytochalasan monomer, was synthesized through unified approach that hinges on Diels–Alder reaction and ring‐closing metathesis reaction. bioinspired reactions aspochalasin B with different epicoccine precursors were then explored, which enabled the divergent access heterodimers B–E as well related congeners. Furthermore, heterotrimer...
Several spiro-fused polycyclic β-lactam derivatives were synthesized in moderate to good yields by Staudinger reaction of 2,4-disubstituted 2,3-dihydro-1,5-benzothiazepines and dibenzo[b,f][1,4]oxazepines with cyclohexanecarboxylic chloride the presence triethylamine anhydrous benzene.1,5-Benzothiazepines gave rise trans-diaryl-substituted fused spiro[1,2-d]benzo [b][1,4]thiazepine-2,1'-cyclohexane]-1(2aH)-ones.In most cases, corresponding amides obtained resulting from hydrolysis...
The title compound, C(9)H(12)N(2)O(3), was synthesized by the reaction of ethyl 2-(4-meth-oxy-phen-oxy)acetate with hydrazine hydrate in ethanol. In acetohydrazide group, N-N bond is relatively short [1.413 (2) Å], suggesting some degree electronic delocalization mol-ecule. crystal, mol-ecules are linked into sheets lying parallel to ab plane N-H⋯N and N-H⋯O hydrogen bonds.
Forty-six novel 3,7-dihydro-purine-2,6-dione derivatives (substituted xanthines) with great structural diversity were synthesized for biological activity screening. Three series of substituted xanthine analogs have been prepared in moderate to excellent yields.
Abstract Objective: Coronary artery bypass grafting (CABG) is associated with antithrombotic therapy in terms of postoperative adverse events; however, it still unknown whether the early use such drugs after CABG safe and effective. In this study, we aim to evaluate relationship between different strategies in-hospital events patients undergoing isolated coronary surgery. Methods: This was a single-center, retrospective cohort analysis due CAD 2001 2012. Data were extracted from Medical...
Abstract C 28 H 20 Cl 2 F N 8 O , triclinic, P 1̅ (no. 2), a = 9.045(3) Å, b 10.907(4) c 15.351(5) α 93.416(7)°, β 95.771(7)°, γ 95.915(6)°, V 1495.0(9) Å 3 Z 4, R gt ( ) 0.0655, wR ref 0.1940, T 293 K.
The Pd-catalyzed N—H insertion reaction of vinyldiazoacetates (II) with o-triflate-anilines (I) followed by a base-promoted cyclization leads to lactones (III).