A5079540222- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Connexins and lens biology
- Antifungal resistance and susceptibility
- Ocular Disorders and Treatments
- Ocular Oncology and Treatments
- Ophthalmology and Eye Disorders
- Traumatic Ocular and Foreign Body Injuries
- Retinal Imaging and Analysis
- Anesthesia and Pain Management
- Diversity and Career in Medicine
- Herpesvirus Infections and Treatments
- Patient Satisfaction in Healthcare
- Legionella and Acanthamoeba research
- Sinusitis and nasal conditions
- Nonmelanoma Skin Cancer Studies
- Advanced Glycation End Products research
Islamic Azad University Medical Branch of Tehran
2025
Universal Scientific Education and Research Network
2025
University of California, San Diego
2015-2024
Smith-Kettlewell Eye Research Institute
2015-2024
Center Point
2021-2024
University of San Diego
2013-2024
American College of Surgeons
2007-2023
UC San Diego Health System
2021
Prevent Blindness
2006-2020
Rabin Medical Center
2020
To evaluate the efficacy and safety of topical cenegermin (recombinant human nerve growth factor) in patients with neurotrophic keratopathy.Multicenter, randomized, double-masked, vehicle-controlled trial.Patients persistent epithelial defect or without stromal thinning.The NGF0214 trial, conducted among 11 sites United States, randomized 48 1:1 to 20 μg/ml vehicle eye drops, 6 drops daily for 8 weeks masked treatment. Follow-up was 24 weeks. Safety assessed all who received study drug....
Abstract The structure of the cornea is vital to its transparency, and dystrophies that disrupt corneal organization are highly heritable. To understand genetic aetiology Fuchs endothelial dystrophy (FECD), most prevalent disorder requiring transplantation, we conducted a genome-wide association study (GWAS) on 1,404 FECD cases 2,564 controls European ancestry, followed by replication meta-analysis, for total 2,075 3,342 controls. We identify three novel loci meeting significance ( P <5 ×...
We generate a renewable supply of corneal endothelial cells (CEC) from human pluripotent stem (PSCs) under defined culture conditions.Corneal cell induction was driven by small molecules in stepwise fashion lineage specification. During the initial phase, PSC fate restricted to eye field-like state and became field (EFSCs). In second PSC-derived EFSCs were further directed toward either neural crest or retinal lineage. The CECs directly induced ocular (NCSCs) suppressing TGF-β ROCK...
Purpose: To explore the role of Rho-associated kinases (ROCK) in corneal physiology and regeneration, effects suppressing its activity stimulating endothelial cell proliferation migration vitro vivo. Methods: Immunohistochemistry was performed to detect RhoA ROCK-1 ROCK-2 human tissue. Adult porcine cells (CECs) were isolated, grown confluence, further characterized. Under treatment ROCK inhibitors, changes cellular distribution profile ZO-1 F-actin examined by immunofluorescence staining....
To study the leading indications and changing trends for penetrating keratoplasty (PK) over past 3 decades.This is a retrospective review of 696 cases PK. The PKs performed at Duke University Eye Center during years 1980-1981, 1990- 1991, 2000-2001 were tabulated to determine decades. main outcome measures PK.During this study, performed. PK their respective frequencies 1990-1991, failed grafts (10.8%, 19.0%, 27.0%, respectively), pseudophakic bullous keratopathy (PBK)/aphakic (ABK) (19.4%,...
The purpose of this study was to evaluate the refractive change after Descemet stripping automated endothelial keratoplasty (DSAEK) surgery and its correlation with graft thickness diameter.We retrospectively analyzed outcomes 45 cases DSAEK that were performed at Duke University Eye Center between August 2005 December 2006. We divided our groups into triple pseudophakic cases. measured manifest refraction preoperatively postoperatively in each group compared difference preoperative...
Purpose of review Oxidative stress plays a central role in cataract pathogenesis, leading cause global blindness. This delves into the oxidative development and key biomarkers – glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), 4-hydroxynonenal (4-HNE) to clarify their functions potential applications predictive diagnostics therapies. Recent findings Antioxidants serve as pivotal markers pathogenesis. GSH affects lens due factors such enzyme depletion altered connexin...
<h3>Objective</h3> To review 30 years' clinical experience with Fuchs corneal endothelial dystrophy leading to penetrating keratoplasty (PK). <h3>Methods</h3> We reviewed the records of patients diagnosed histopathologically as having who underwent PK at Duke University Medical Center between January 1, 1972, and December 31, 2001. This observational case series included 424 (546 eyes). <h3>Results</h3> Women represented 77.6% patients. Mean age time for all was 69.2 years. Bilateral...
Fuchs endothelial corneal dystrophy (FECD) is a common, late-onset disorder of the endothelium. Although progress has been made in understanding genetic basis FECD by studying large families which phenotype transmitted an autosomal dominant fashion, recently reported genome-wide association study identified common alleles at locus on chromosome 18 near TCF4 confer susceptibility to FECD. Here, we report findings our independent validation for using largest dataset date (450 cases and 340...
PAX6 is a master regulatory gene involved in neuronal cell fate specification. It also plays critical role early eye field and subsequent limbal stem (LSC) determination during development. Defects Pax6 cause aniridia LSC deficiency humans the Sey (Small eye) phenotype mice (Massé, K., Bhamra, S., Eason, R., Dale, N., Jones, E. A. (2007) Nature 449, 1058-1062). However, how specifies corneal fates development not well understood. Here, we show that expressed primitive cup later tissue...
<h3>Background</h3> Corneal intraepithelial dyskeratosis is an extremely rare condition. The classical form, affecting Native American Haliwa-Saponi tribe members, called hereditary benign (HBID). Herein, we present a new form of corneal for which identified the causative gene by using deep sequencing technology. <h3>Methods and results</h3> A seven member Caucasian French family with two affected individuals (6-year-old proband his mother) was ascertained. presented bilateral complete...
Given the rise in cases of fungal keratitis recent years, this study was performed to better elucidate microbiological profile, risk factors, and surgical intervention rates at a tertiary referral center Southeastern USA.This is retrospective case series infections treated Duke University Eye Center from January 1, 1998, October 6, 2008. Of 4651 culture-proven corneal ulcers identified, 63 (1.4 %) were positive for with total 69 organisms isolated. The majority isolates filamentous species...