A5086287193- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Pluripotent Stem Cells Research
- Ocular Surface and Contact Lens
- Retinal and Optic Conditions
- Corneal surgery and disorders
- Renal and related cancers
- Ophthalmology and Visual Impairment Studies
- Retinal and Macular Surgery
- Optical Coherence Tomography Applications
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Intraocular Surgery and Lenses
- Porphyrin and Phthalocyanine Chemistry
- Photoacoustic and Ultrasonic Imaging
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- HIV-related health complications and treatments
- Thyroid Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- DNA Repair Mechanisms
- Photodynamic Therapy Research Studies
Rutgers, The State University of New Jersey
2022-2024
Spanish National Cancer Research Centre
2018-2024
Rutgers Cancer Institute of New Jersey
2022-2023
Princeton University
2022
Ludwig Cancer Research
2022
Icahn School of Medicine at Mount Sinai
2019-2020
Tisch Cancer Institute
2019-2020
University of California, San Diego
2009-2019
Smith-Kettlewell Eye Research Institute
2018
Jacobs (United States)
2010-2015
Abstract Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence aging and offer therapeutic interventions. Here we report identification Cardiac Glycosides (CGs) as a family compounds senolytic activity. CGs, by targeting Na+/K+ATPase pump, cause disbalanced electrochemical gradient within cell causing depolarization acidification. Senescent cells present slightly depolarized plasma membrane higher concentrations H+, making...
Photosensitizer, protoporphyrin IX (PpIX), was conjugated with Au nanoparticles (Au NPs) of 19, 66, and 106 nm diameter to study the size-dependent enhancement reactive oxygen species (ROS) formation enabled by NPs. The ROS ratio is determined be 1:2.56:4.72 in order increasing NP size, general agreement theoretically calculated field fourth power. convergence experimental simulated results suggests that NP-enhanced can attributed directly localized electromagnetic as a result surface...
To determine the effect of drusen and geographic atrophy (GA) in dry age-related macular degeneration on retinal sensitivity using an eye tracking scanning laser ophthalmoscope microperimetry.A total 44 eyes from 22 patients with 11 GA were imaged microperimetry (OPKO Health, Miami, FL). A custom pattern was used to evaluate a Goldmann III size target (108 μm retina). The perimetry 4-2 stepladder algorithm maximal sensitivity. Microperimetry optical coherence tomography performed...
Differentiated thyroid cancer (DTC) affects thousands of lives worldwide each year. Typically, DTC is a treatable disease with good prognosis. Yet, some patients are subjected to partial or total thyroidectomy and radioiodine therapy prevent local recurrence metastasis. Unfortunately, and/or often worsen(s) quality life might be unnecessary in indolent cases. On the other hand, lack biomarkers indicating potential metastatic imposes an additional challenge managing treating this disease.The...
Immune checkpoint blockade (ICB) has transformed cancer treatment, but success rates remain low in most cancers. Recent research suggest that dietary fiber enhances ICB response melanoma patients and murine preclinical models through microbiome-dependent mechanisms. Yet, the robustness of this effect across types contexts remains unclear. Specifically, prior literature compared grain-based chow (high fiber) to low-fiber purified diet, these diets differ also on other dimensions including...
Report23 February 2020Open Access Transparent process Proteasome mapping reveals sexual dimorphism in tissue-specific sensitivity to protein aggregations Edmund Charles Jenkins Division of Hematology/Oncology, Department Medicine, Icahn School Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, USA Search for more papers by this author Nagma Shah Maria Gomez Gabriella Casalena Feil Family Brain and Mind Research Weill Cornell Dazhi Zhao Timothy C Kenny Sara Rose Guariglia City...
To evaluate the integrity of photoreceptor inner segment/outer segment (IS/OS) junction after change drusen size in age-related macular degeneration using spectral-domain optical coherence tomography.Drusen volume raster scans were performed with Spectralis tomography (Heidelberg Engineering) through 2,624 14 eyes clinically dry degeneration, which had been longitudinally followed-up between 23 and 28 months without intervention (mean, 26.3 months). All Early Treatment Diabetic Retinopathy...
Purpose: To assess early retinal microvascular and functional changes in diabetic patients without clinical evidence of retinopathy with optical coherence tomography angiography central visual analyzer. Methods: This was an observational case–control study nondiabetic controls. Patients underwent imaging acuity testing using the The foveal avascular zone area capillary density superficial deep plexuses were measured manually by a masked grader. Results: Sixty eyes from 35 included group, 45...
Abstract Aging is characterized by a gradual functional decline of tissues with age. Adult stem and progenitor cells are responsible for tissue maintenance, repair, regeneration, but during aging, this population decreased or its activity reduced, compromising integrity causing pathologies that increase vulnerability, ultimately lead to death. The causes cell exhaustion aging not clear, whether reduction in function cause consequence remains unresolved. Here, we took advantage mouse model...
HIV retinopathy is the most common non-infectious complication in eyes of HIV-positive individuals. Oncotic lesions retinal nerve fiber layer, referred to as cotton wool spots (CWS), and intraretinal (IR) hemorrhages are frequently observed but not unique this pathology. patients have impaired color vision contrast sensitivity, which worsens with age. Evidence inner–retinal damage been documented ophthalmoscopically, however their long term structural effect has investigated. It hypothesized...
Autophagy defects are a risk factor for inflammatory bowel diseases (IBDs) through unknown mechanisms. Whole-body conditional deletion of autophagy-related gene (Atg) Atg7 in adult mice (Atg7Δ/Δ) causes tissue damage and death within 3 mo due to neurodegeneration without substantial effect on intestine. In contrast, we report here that whole-body other essential Atg genes Atg5 or Fip200/Atg17 (Atg5Δ/Δ Fip200Δ/Δ) caused 5 d rapid autophagy inhibition, elimination ileum stem cells, loss...
Objectives:To demonstrate and confirm the existence of cyclin D1–positive diffuse large B-cell lymphoma (DLBCL) with IGH-CCND1 rearrangement discuss rationale differentiating this entity from blastoid pleomorphic variants mantle cell (MCL).
Purpose To determine the presence of structural changes in HIV retinae (i.e., photoreceptor density and retinal thickness macula) compared with age-matched HIV-negative controls. Methods Cohort patients known under CART (combination Antiretroviral Therapy) treatment were examined a flood-illuminated AO camera to assess cone mosaic spectral-domain optical coherence tomography (SD-OCT) layers thickness. Results Twenty-four eyes 12 (n = 6 HIV-positive HIV-negative) imaged adaptive optics...