A5100383026- Cancer Genomics and Diagnostics
- Analytical Chemistry and Sensors
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- BRCA gene mutations in cancer
- Gas Sensing Nanomaterials and Sensors
- Trace Elements in Health
- Thyroid Cancer Diagnosis and Treatment
- Acoustic Wave Resonator Technologies
- Nutrition, Genetics, and Disease
- Bioinformatics and Genomic Networks
- COVID-19 Clinical Research Studies
- Gene expression and cancer classification
- Cancer Cells and Metastasis
- Genetic Associations and Epidemiology
- DNA Repair Mechanisms
- SARS-CoV-2 detection and testing
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- Genetics, Aging, and Longevity in Model Organisms
- Pancreatic and Hepatic Oncology Research
- Molecular Biology Techniques and Applications
- Drug Transport and Resistance Mechanisms
- Immune Cell Function and Interaction
- Cardiomyopathy and Myosin Studies
Rutgers, The State University of New Jersey
2002-2023
Rutgers Cancer Institute of New Jersey
2018-2023
Johnson University
2020
Rutgers Sexual and Reproductive Health and Rights
2020
Abstract In less than nine months, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) killed over a million people, including >25,000 in New York City (NYC) alone. The COVID-19 pandemic caused by SARS-CoV-2 highlights clinical needs to detect infection, track strain evolution, and identify biomarkers of disease course. To address these challenges, we designed fast (30-minute) colorimetric test (LAMP) for infection from naso/oropharyngeal swabs large-scale shotgun...
Differentiated thyroid cancer (DTC) affects thousands of lives worldwide each year. Typically, DTC is a treatable disease with good prognosis. Yet, some patients are subjected to partial or total thyroidectomy and radioiodine therapy prevent local recurrence metastasis. Unfortunately, and/or often worsen(s) quality life might be unnecessary in indolent cases. On the other hand, lack biomarkers indicating potential metastatic imposes an additional challenge managing treating this disease.The...
We have investigated the folding of myosin motor domain using a chimera an embryonic striated muscle II fused on its COOH terminus to thermal stable, fast variant green fluorescent protein (GFP). In in vitro expression assays, GFP chimeric protein, S1795GFP, folds rapidly enabling us monitor fluorescence. The very slowly and transits through multiple intermediates that are detectable by gel filtration chromatography. distribution nascent among these is strongly dependent upon temperature. At...
Purpose: Zinc metallochaperones (ZMC) are a new class of anticancer drugs that reactivate zinc-deficient mutant p53 by raising and buffering intracellular zinc levels sufficiently to restore binding. In vitro pharmacodynamics ZMCs indicate p53-mutant activity is ON 4-6 hours OFF 24. We sought understand the mechanism this regulation translate these findings preclinically. further innovate formulation improve efficacy.Experimental Design: performed in mechanistic studies determine role...
Abstract Latent recurrences following curative-intent pancreatic cancer surgery is a major clinical problem thought to be due the reactivation of dormant tumor cells that disseminate before primary has been removed. How dormancy established and ultimately reversed drive recurrence poorly understood. Here we introduce novel model mimics early latent survival outcomes resected patients. Using single-cell transcriptomics compared primary, dormant, reactivated found cell transcriptomes clustered...
Abstract Inherited mutations in BRCA1 , BRCA2 and PALB2 cause a high risk of breast cancer. Here, we conducted parallel conditional knockout (CKO) Brca1 Palb2 Brca2 individually combination, along with one copy Trp53 the mammary gland nulliparous female mice. We observed functional equivalence three genes their basic tumor-suppressive activity, linear epistasis but complementary roles tumor suppression, as combined ablation either or led to delayed formation. Whole-exome sequencing (WES)...
The medical diagnostics laboratories are showing an urgent need for accurate, fast and inexpensive biosensors. A zinc oxide (ZnO) nanotip-based quartz crystal microbalance (QCM) sensor is developed as a solution accurate QCM composed of single crystalline ZnO nanotips grown on top gold electrode using metal-organic chemical vapor deposition (MOCVD). Scanning electron microscopy (SEM) shows that the uniformly aligned with their c-axis normal to surface, giving large surface area sample...
Abstract Chronic infection of hepatitis B virus (HBV) is the major cause hepatocellular carcinoma (HCC). Notably, 90% HBV‐positive HCC cases exhibit detectable HBV integrations, hinting at potential early entanglement these viral integrations in tumorigenesis and their subsequent oncogenic implications. Nevertheless, precise chronology integration events during tumorigenesis, alongside sequential structural patterns, has remained elusive thus far. In this study, we applied whole‐genome...
Biological paths of tumor progression are difficult to predict without time-series data. Using median shift and abacus transformation in the analysis RNA sequencing data sets, natural patient stratifications were found based on their transcriptomic burden (TcB). gene-behavior analysis, TcB groups evaluated further discover biological courses progression. We that solid tumors hematological malignancies (n = 4179) share conserved patterns, network complexity decreases at increasing levels. An...
The BRCA1-PALB2-BRCA2 axis, or the BRCA pathway, plays key roles in genome stability maintenance and suppression of breast several other cancers. Due to frequent p53 mutations human BRCA1 cancers mouse mammary tumors from Brca1, Brca2 Palb2 conditional knockout models, it is often thought that inactivation accelerates BRCA1/2 PALB2-associated tumorigenesis. Here, we studied tumor development mice with a mutation disengages PALB2-BRCA1 interaction different Trp53 backgrounds. Rather than...
ABSTRACT Differentiated thyroid cancer (DTC) affects thousands of lives worldwide every year. Typically, DTC is a treatable disease with good prognosis. Yet, some patients are subjected to partial or total thyroidectomy and radioiodine therapy prevent local recurrence metastasis. Unfortunately, and/or often worsen(s) the quality life might be unnecessary in indolent cases. This clinical setting highlights unmet need for precise molecular diagnosis DTC, which should dictate appropriate...
Abstract The p53 transcription factor functions as one of cancer’s most potent tumor suppressors and is the frequently mutated gene in human cancer. majority mutations (>70%) are missense that generate a defective protein found at high levels cells targetable. Restoration wild type structure function mutant with small molecule (so-called reactivation) highly sought after goal anticancer drug development. requires binding single zinc ion to fold properly, impair protein’s ability bind...