A5000057129- Estrogen and related hormone effects
- Genomics, phytochemicals, and oxidative stress
- DNA Repair Mechanisms
- Hormonal Regulation and Hypertension
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- BRCA gene mutations in cancer
- Free Radicals and Antioxidants
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Mitochondrial Function and Pathology
- Nutrition, Genetics, and Disease
- Parathyroid Disorders and Treatments
- Cancer-related Molecular Pathways
- Renal Diseases and Glomerulopathies
- Genetic Associations and Epidemiology
- Science, Research, and Medicine
- 14-3-3 protein interactions
- Diversity and Career in Medicine
- Urticaria and Related Conditions
- Health, Environment, Cognitive Aging
- Cell death mechanisms and regulation
- Genetics, Aging, and Longevity in Model Organisms
- Cholinesterase and Neurodegenerative Diseases
University Hospitals Birmingham NHS Foundation Trust
2024
Rutgers, The State University of New Jersey
2017-2022
Rutgers Cancer Institute of New Jersey
2017-2022
Johnson University
2018-2022
Mustansiriyah University
2020-2021
King Saud bin Abdulaziz University for Health Sciences
2020
Royal Shrewsbury Hospital
2019
Shrewsbury and Telford Hospital NHS Trust
2019
Abstract NRF2 is a transcription factor serving as master regulator of the expression many genes involved in cellular responses to oxidative and other stresses. In absence stress, constantly synthesized but maintained at low levels it targeted by KEAP1 for ubiquitination proteasome-mediated degradation. binds mainly through conserved “ETGE” motif that has also been found several proteins, such DPP3, which shown bind enhance function upon overexpression. Here we demonstrate interaction...
The BRCA1-PALB2-BRCA2 axis plays an essential role in DNA homologous recombination repair, defect which drives genome instability and cancer development. How cells with defects this pathway respond to damage vivo how tumors develop from these remain poorly defined. Here, we analyzed several aspects of the response multiple tissues Palb2-mutant mice interaction between PALB2 BRCA1 is disengaged. Without any challenge, mutant showed increased endogenous damage. Following ionizing radiation,...
The PALB2 tumor suppressor plays key roles in DNA repair and has been implicated redox homeostasis. Autophagy maintains mitochondrial quality, mitigates oxidative stress suppresses neurodegeneration. Here we show that Palb2 deletion the mouse brain leads to mild motor deficits co-deletion of with essential autophagy gene Atg7 accelerates exacerbates neurodegeneration induced by ATG7 loss. elevated damage, markers, especially Purkinje cells, results accelerated cell Further analyses suggest...
Abstract Inherited mutations in BRCA1 , BRCA2 and PALB2 cause a high risk of breast cancer. Here, we conducted parallel conditional knockout (CKO) Brca1 Palb2 Brca2 individually combination, along with one copy Trp53 the mammary gland nulliparous female mice. We observed functional equivalence three genes their basic tumor-suppressive activity, linear epistasis but complementary roles tumor suppression, as combined ablation either or led to delayed formation. Whole-exome sequencing (WES)...
There is a global decline in interest careers renal medicine. This concerning given the increasing burden of kidney disease. Previous studies USA and Australia have identified factors such as poor work-life balance, lack role models challenging nature speciality possible reasons behind recruitment struggles. study aimed to identify associated with declining among trainees UK. We conducted survey 150 National Health Service Foundation (interns) Core Medical Trainees Education West Midlands....
A man in his 40s with end-stage kidney disease due to IgA nephropathy and receiving peritoneal dialysis presented a 1-week history of breathlessness, cough nosebleeds. CT scan the chest revealed ground glass changes while blood tests indicated elevated inflammatory markers negative vasculitis screen. This included ANCA anti-GBM antibodies. Initial treatment for suspected atypical pneumonia antibiotics yielded no clinical improvement. Over course admission, symptoms progressively worsened,...
The BRCA1-PALB2-BRCA2 axis, or the BRCA pathway, plays key roles in genome stability maintenance and suppression of breast several other cancers. Due to frequent p53 mutations human BRCA1 cancers mouse mammary tumors from Brca1, Brca2 Palb2 conditional knockout models, it is often thought that inactivation accelerates BRCA1/2 PALB2-associated tumorigenesis. Here, we studied tumor development mice with a mutation disengages PALB2-BRCA1 interaction different Trp53 backgrounds. Rather than...
Introduction: The COVID-19 pandemic has affected the whole world in different levels from numerous aspects. This deadly, highly contagious viral infection led to lockdown many cities across world; significantly disrupting previously planned educational activities. Objectives: We aim evaluate impact of on and academic activities health care professionals practicing countries. Subjects Methods: A cross-sectional survey was conducted using a link an online questionnaire which sent doctors,...
An interesting feature of ionizing radiation, especially Gamma and X-rays as a DNA damaging factor is the range lesions it induces. γ-H2AX foci are documented to represent double-strand breaks (DSBs) biomarker for radiation-induced damage. Study design 42 adult male mice Albino BALB/c, had been divided randomly into 6 groups seven each. Group 1 received standard saline solution untreated also, do not expose radiation. 2 vitamin C (VC) (200 mg/kg.day) intra-peritoneal (i.p.) injected 8 days...
To investigate the relationship between parathyroid gland weight and high-density lipoprotein (HDL) levels in patients with primary hyperparathyroidism (PHPT).In this retrospective case control study, we reviewed 329 PHPT aged from 20 to 85 years who had a parathyroidectomy at Robert Wood Johnson University Hospital. The were divided into 5 quintiles according their weight: 68 <0.3 g, 66 0.3-0.45 67 0.45-0.7 63 0.7-1.25 65 ≥1.25 g.Body Mass Index (BMI) trended be higher across of (P =...
<div>Abstract<p>NRF2 is a transcription factor serving as master regulator of the expression many genes involved in cellular responses to oxidative and other stresses. In absence stress, NRF2 constantly synthesized but maintained at low levels it targeted by KEAP1 for ubiquitination proteasome-mediated degradation. binds mainly through conserved “ETGE” motif that has also been found several proteins, such DPP3, which shown bind enhance function upon overexpression. Here we...
<p>Effect of mutating individual cysteine residues KEAP1 on DPP3 binding.</p>
<p>High DPP3 mRNA expression correlates with poor relapse-free survival (RFS) of breast cancer patients in the Kaplan-Meier Plotter database.</p>
<p>mRNA levels of DPP3, NRF2, NQO1, GCLM, KEAP1 and p62 in MCF7 cell lines stably overexpressing wt mutant DPP3 species.</p>
<p>Effect of mutating individual cysteine residues DPP3 on its interaction with KEAP1.</p>
<p>Effect of N-acetylcystein (NAC) on the DPP3-KEAP1 interaction.</p>
<p>Quantification of mRNA amount, qRT-PCR primer sequences, and transfection immunoprecipitation methods.</p>
<p>mRNA levels of DPP3, NRF2, NQO1, GCLM, KEAP1 and p62 in MCF7 cell lines stably overexpressing wt mutant DPP3 species.</p>
<p>Effect of mutating individual cysteine residues KEAP1 on DPP3 binding.</p>
<p>Effect of N-acetylcystein (NAC) on the DPP3-KEAP1 interaction.</p>
<p>High DPP3 mRNA expression correlates with poor relapse-free survival (RFS) of breast cancer patients in the Kaplan-Meier Plotter database.</p>
<p>Quantification of mRNA amount, qRT-PCR primer sequences, and transfection immunoprecipitation methods.</p>
<p>Effect of mutating individual cysteine residues DPP3 on its interaction with KEAP1.</p>