A5101675825- Glaucoma and retinal disorders
- Cancer Immunotherapy and Biomarkers
- Synthesis and biological activity
- Shoulder Injury and Treatment
- Retinal Diseases and Treatments
- Biochemical and Molecular Research
- Oral Health Pathology and Treatment
- Retinal Imaging and Analysis
- Airway Management and Intubation Techniques
- Bioactive Compounds and Antitumor Agents
- Protein Structure and Dynamics
- Cholinesterase and Neurodegenerative Diseases
- Endoplasmic Reticulum Stress and Disease
- Natural Antidiabetic Agents Studies
- Alzheimer's disease research and treatments
- Corneal surgery and disorders
- Cancer Research and Treatments
- Oral and Maxillofacial Pathology
- Immune cells in cancer
- Survey Sampling and Estimation Techniques
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Heat shock proteins research
- Gout, Hyperuricemia, Uric Acid
- Gastrointestinal motility and disorders
Guru Nanak Dev University
2021-2025
Lakshmibai National Institute of Physical Education
2022-2024
Pharma Medica Research (Canada)
2024
BLK Super Speciality Hospital
2024
Manipal Hospital
2024
Indian Institute of Technology Mandi
2024
Maharishi Markandeshwar University, Mullana
2021-2024
University of Illinois Chicago
2024
Chandigarh University
2024
Indraprastha Apollo Hospitals
2023
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and major cause cancer related deaths worldwide. Only 10 to 20% HCC can be surgically excised. Therefore, chemotherapeutic intervention treatment essential for achieving favorable prognosis. However, therapeutic outcome chemotherapy generally poor owing inherent resistance cells or due development acquired resistance. To differentiate delineate molecular events, we developed drug resistant Hep3B (DRC) by treating with...
Abstract Inhibitors of poly-ADP-ribose polymerase 1 (PARPi) are highly effective in killing cells deficient homologous recombination (HR); thus, PARPi have been clinically utilized to successfully treat BRCA2-mutant tumors. However, positive response is not universal, even among patients with HR-deficiency. Here, we present the results genome-wide CRISPR knockout and activation screens which reveal genetic determinants wildtype or BRCA2-knockout cells. Strikingly, report that depletion...
A novel series of triazole-linked isatin-indole-3-carboxaldehyde hybrids based on the febuxostat skeleton and its binding site interactions were rationally designed synthesized as potential xanthine oxidase inhibitors. Among hybrids, A19 showed most potent inhibition (IC50 = 0.37 µM) with mixed-type inhibitory scenario. Structure-activity relationship studies revealed that methoxy (OCH3 ) substitution position 5 isatin nucleus a two-carbon distance between triazole moiety is tolerable for...
Differentiated thyroid cancer (DTC) affects thousands of lives worldwide each year. Typically, DTC is a treatable disease with good prognosis. Yet, some patients are subjected to partial or total thyroidectomy and radioiodine therapy prevent local recurrence metastasis. Unfortunately, and/or often worsen(s) quality life might be unnecessary in indolent cases. On the other hand, lack biomarkers indicating potential metastatic imposes an additional challenge managing treating this disease.The...
Abstract Considerable ingenuity has been shown in the recent years discovery of novel xanthine oxidase (XO) inhibitors that fall outside purine scaffold. The triazole nucleus cornerstone for development many enzyme clinical management several diseases, where hyperuricemia is one them. Here, we give a critical overview significant research on triazole‐based XO inhibitors, with respect to their design, synthesis, inhibition potential, toxicity, and docking studies, done till now. Based these...
In sample surveys, dealing with missingness in data is one of the most frequent problem that can be handled by replacing missing values some imputed values. addition to such missingness, oftenly provided respondents are under reported or over which results “Measurement Error”. this paper, we have proposed three modified regression type estimators population mean, using Factor-Type imputation strategy two-phase sampling set up deal and measurement error. While proposing our efficient...
A series of 5-(substituted benzylidene) thiazolidine-2,4-dione and coumarin hybrids (I-1 to I-16) were designed synthesized explore key structural requirements for effective α-glucosidase inhibitors. Molecular docking studies conducted investigate their interactions with various targets, including DPP-4, α-glucosidase, α-amylase, PPAR-γ. The scores binding energies indicated that Compound I-1 emerged as the optimal scaffold drug design, excluding α-amylase. was based on insights gained from...
In continuous efforts to develop anti-Alzheimer's agents, we rationally designed and synthesized a series of multitargeting molecules by incorporating the essential molecular features standard drug donepezil. Among series, compound 4b showed properties act as an agent, which is better tolerable in vivo than Acetylcholinesterase (AChE) inhibition data that inhibits enzyme with half-maximal inhibitory concentration (IC50) value 0.78 μM also DNA protection, was confirmed through nicking assay,...
AbstractHeat shock proteins (Hsps) modulate several cellular functions and are ubiquitously present in cell. Here, we investigated alterations the expression of Hsps explored functional consequences same. Moreover, effect quercetin (Qctn), an inhibitor Hsps, on chemotherapeutic drugs treatment hepatoma cells Hep3B HepG2 was investigated. We for first time report that 5-fluorouracil (5-FU) carboplatin specifically induce Hsp40 addition to Hsp27 cells. Induction following exposure sub lethal...
Background: Mature symptomatic pancreatic pseudocysts require surgical intervention for their management. In this era of minimal access surgery, several reports are now available laparoscopic management pseudocysts. Patients and Methods: We have performed procedure in five patients over the past 2 years. Four developed pseudocyst after acute alcoholic pancreatitis one following biliary pancreatitis. The diameter ranged from 8 to 12 cm. was using ports. Harmonic Scalpel used create two ports...
Alzheimer's disease (AD) is the most common cause of dementia worldwide in older population. There no disease-modifying therapy available for AD. The current standard care drug AD cholinesterase inhibitors, including donepezil. Bacopa monnieri or brahmi used traditional Indian medicine memory loss. We conducted a phase 2b randomized controlled trial (RCT) to find out efficacy and donepezil mild cognitive impairment (MCI).The study was planned as 52 week, randomized, double-blind,...
Abstract The pathobiology of rheumatoid inflammatory diseases, including arthritis (RA) and psoriatic arthritis, involves the interplay between innate adaptive immune components resident synoviocytes. Single-cell analyses patient samples relevant mouse models have characterized many cellular subsets in RA. However, impact interactions cell types is not fully understood. In this study, we temporally profiled murine arthritic synovial isolates at single-cell level to identify perturbations...
Due to substantial technical improvements, clinical application of heat as a co-adjuvant in cancer treatment is acquiring new interest. The effect hyperthermia on hepatoma cell lines Hep3B (p53 defective) and HepG2 wild type) when investigated led an interesting observation that cells are more susceptible stress than cells. In addition, heat-induced carboplatin resistance was observed only. To investigate the reasons, shock response explored it augmented protein 70 (Hsp70) expression levels...
Glaucoma is the largest cause of irreversible blindness affecting more than 60 million people globally. The disease defined as a gradual loss peripheral vision due to death Retinal Ganglion Cells (RGC). RGC largely influenced by rate aqueous humor production ciliary processes and its passage through trabecular meshwork (TM) in anterior part eye. Primary open angle glaucoma (POAG), most common subtype, genetically complex disease. Multiple genes many loci have been reported be involved POAG...