A5065693316- Synthesis and biological activity
- Cholinesterase and Neurodegenerative Diseases
- Click Chemistry and Applications
- Gout, Hyperuricemia, Uric Acid
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Biochemical and Molecular Research
- Multicomponent Synthesis of Heterocycles
- Hepatitis C virus research
- Protein Hydrolysis and Bioactive Peptides
- Enzyme function and inhibition
- Folate and B Vitamins Research
- Phytase and its Applications
- Bioactive Compounds and Antitumor Agents
- Eosinophilic Disorders and Syndromes
- Blood Pressure and Hypertension Studies
- Quinazolinone synthesis and applications
- Curcumin's Biomedical Applications
- Free Radicals and Antioxidants
- Phosphodiesterase function and regulation
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Estrogen and related hormone effects
- Synthesis and Characterization of Pyrroles
- Neuroscience and Neuropharmacology Research
Guru Nanak Dev University
2006-2025
Baba Farid University of Health Sciences
2024
Keeping in view various pharmacological attributes of indole and coumarin derivatives, a new series indolindione-coumarin molecular hybrids was rationally designed synthesized. All synthesized hybrid molecules were evaluated for their antimicrobial potential against Gram-negative bacterial strains (Escherichia coli Salmonella enterica), Gram-positive (Staphylococcus aureus Mycobacterium smegmatis), four fungal (Candida albicans, Alternaria mali, Penicillium sp., Fusarium oxysporum) by using...
Keeping in view various pharmacological attributes of curcumin, coumarin, and isatin derivatives, triazole-tethered monocarbonyl curcumin-coumarin curcumin-isatin molecular hybrids have been synthesized evaluated for their antibacterial potential against Gram-positive (Enterococcus faecalis Staphylococcus aureus) Gram-negative (Pseudomonas aeruginosa Escherichia coli) human pathogenic bacterial strains. Among all hybrid molecules, A-4 B-38 showed the most potent activity with inhibition...
A novel series of triazole-linked isatin-indole-3-carboxaldehyde hybrids based on the febuxostat skeleton and its binding site interactions were rationally designed synthesized as potential xanthine oxidase inhibitors. Among hybrids, A19 showed most potent inhibition (IC50 = 0.37 µM) with mixed-type inhibitory scenario. Structure-activity relationship studies revealed that methoxy (OCH3 ) substitution position 5 isatin nucleus a two-carbon distance between triazole moiety is tolerable for...
Abstract Considerable ingenuity has been shown in the recent years discovery of novel xanthine oxidase (XO) inhibitors that fall outside purine scaffold. The triazole nucleus cornerstone for development many enzyme clinical management several diseases, where hyperuricemia is one them. Here, we give a critical overview significant research on triazole‐based XO inhibitors, with respect to their design, synthesis, inhibition potential, toxicity, and docking studies, done till now. Based these...
A series of 5-(substituted benzylidene) thiazolidine-2,4-dione and coumarin hybrids (I-1 to I-16) were designed synthesized explore key structural requirements for effective α-glucosidase inhibitors. Molecular docking studies conducted investigate their interactions with various targets, including DPP-4, α-glucosidase, α-amylase, PPAR-γ. The scores binding energies indicated that Compound I-1 emerged as the optimal scaffold drug design, excluding α-amylase. was based on insights gained from...
In continuous efforts to develop anti-Alzheimer's agents, we rationally designed and synthesized a series of multitargeting molecules by incorporating the essential molecular features standard drug donepezil. Among series, compound 4b showed properties act as an agent, which is better tolerable in vivo than Acetylcholinesterase (AChE) inhibition data that inhibits enzyme with half-maximal inhibitory concentration (IC50) value 0.78 μM also DNA protection, was confirmed through nicking assay,...
Lack of treatment novel Coronavirus disease led to the search specific antivirals that are capable inhibit replication virus. The plant kingdom has demonstrated be an important source new molecules with antiviral potential.The present study aims utilize various computational tools identify most eligible drug candidate have capabilities halt SARS-COV-2 virus by inhibiting Main protease (Mpro) enzyme.We selected plants whose extracts inhibitory potential against previously discovered...
Novel coronavirus disease, a serious challenge for the healthcare system, has diverted all researchers toward exploration of potential targets, compounds or vaccines management this disease. Mpro enzyme was found to be crucial replication virus which makes an attractive drug target SARS-CoV-2. Diverse pharmacological profile Alkannin/shikonin (A/S) derivatives build up curiosity study their antiviral profile. Therefore, current utilises various computational tools screen and evaluate...